Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

December 22, 2020 0 By Keith

Intramembrane proteases (IMPs) are a novel class of proteases that catalyze the proteolysis inside the membrane and regulate numerous mobile processes in numerous organisms. RseP, an Escherichia coli site-2 protease (S2P) household IMP, is concerned within the regulation of an extracytoplasmic stress response via the cleavage of membrane-spanning anti-stress-response transcription issue (anti-σE) protein RseA. Extracytoplasmic stresses set off a sequential cleavage of RseA, by which first DegS cleaves off its periplasmic area, and RseP catalyzes the second cleavage of RseA. The 2 tandem-arranged periplasmic PDZ (PDZ tandem) domains of RseP function a size-exclusion filter which prevents the entry of an intact RseA into the energetic website of RseP IMP area. Nevertheless, RseP’s substrate recognition mechanism is just not absolutely understood.

Right here, we discovered {that a} periplasmic area of RseP, situated downstream of the PDZ tandem, comprises a phase (named H1) predicted to kind an amphiphilic helix. Bacterial S2P homologs with numerous numbers of PDZ domains have the same amphiphilic helix within the corresponding area. We demonstrated that the H1 phase types {a partially} membrane-embedded amphiphilic helix on the periplasmic floor of the membrane.

Systematic and random mutagenesis analyses revealed that the H1 helix is necessary for the soundness and proteolytic operate of RseP and that mutations within the H1 phase can have an effect on the PDZ-mediated substrate discrimination. Cross-linking experiments urged that H1 instantly interacts with the DegS-cleaved type of RseA. We suggest that H1 acts as an adaptor required for correct association of the PDZ tandem area to carry out its filter operate and for substrate positioning for its environment friendly cleavage.

 

Tripeptidyl peptidase I promotes human endometrial epithelial cell adhesive capability implying a job in receptivity

The endometrium undergoes cyclic remodelling all through the menstrual cycle in preparation for embryo implantation which happens in a brief window through the mid-secretory part. It’s throughout this quick ‘receptive window’ that the endometrial luminal epithelium acquires adhesive capability allowing blastocysts agency adhesion to the endometrium to determine being pregnant. Dysregulation in any of those steps can compromise embryo implantation leading to implantation failure and infertility. Many elements contribute to those processes together with and proteases.
Tripeptidyl peptidase 1  is a is a lysosomal serine-type protease nevertheless the contribution of the TPP1 to receptivity is unknown. We aimed to research the function of receptivity in people.Within the present research, TPP1 was expressed in each epithelial and stromal compartments of the endometrium throughout the menstrual cycle. Expression was confined to the cytoplasm of luminal and glandular epithelial cells and stromal cells. Staining of mid-secretory endometrial tissues of ladies with regular fertility and first unexplained infertility confirmed lowered immunostaining depth of TPP1 in luminal epithelial cells of infertile tissues in comparison with fertile tissues.
In contrast, TPP1 ranges in glandular epithelial and stromal cells had been comparable in each teams within the mid-secretory part. Inhibition of TPP1 utilizing siRNA compromised HTR8/SVneo (trophoblast cell line) spheroid adhesion on siRNA-transfected Ishikawa cells (endometrial epithelial cell line) in vitro. This impairment was related to decreased sirtuin 1 (SIRT1), BCL2 and p53 mRNA and unaltered and LIF receptor gene expression between remedy teams. siRNA knockdown of TPP1 in main human endometrial stromal cells didn’t have an effect on decidualization nor the expression of decidualization markers prolactin (PRL) and insulin-like development factor-binding protein 1 (IGFBP1). Taken collectively, our knowledge strongly suggests a job for TPP1 in endometrial receptivity by way of its results on epithelial cell adhesion and suggests lowered ranges related to unexplained infertility might contribute to implantation failure.
 Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

Vildagliptin, a dipeptidyl peptidase-Four inhibitor, reduces betel-nut induced carcinogenesis in feminine mice

Purpose: Betel-nut, a well-liked masticatory amongst Southeast Asian populations is a category I carcinogen, beforehand related to dyslipidemia and aberrant lipid metabolism, and is reported for use extra regularly by females, than males. This research investigates the potential of repurposing the anti-diabetic drug, vildagliptin, a dipeptidyl peptidase-Four inhibitor, for assuaging the oncogenic situation in feminine Swiss Albino mice administered an aqueous extract of betel-nut (AEBN) orally (2 mg ml-1) for 24 weeks.
Primarystrategies: Tissues had been investigated by histopathological, immunohistochemical and apoptosis assays. Biochemical analyses of oxidative stress markers and lipid profile had been carried out utilizing completely different tissues and sera. The expressions of various proteins concerned in lipid metabolism and oncogenic pathways had been evaluated by Western blotting.

Human SERPINC1(Serpin C1) ELISA Kit

EH0560 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375 ng/ml

Mouse Serpin H1 (Serpinh1)

1-CSB-YP021087MO
  • EUR 604.80
  • EUR 318.00
  • EUR 2198.40
  • EUR 915.60
  • EUR 1459.20
  • EUR 400.80
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Serpin H1(Serpinh1) expressed in Yeast

Mouse Serpin H1 (Serpinh1)

1-CSB-EP021087MO
  • EUR 606.00
  • EUR 318.00
  • EUR 2192.40
  • EUR 919.20
  • EUR 1461.60
  • EUR 402.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Serpin H1(Serpinh1) expressed in E.coli

Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E03C0353-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E03C0353-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E03C0353-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Antithrombin-III/Serpin C1 ELISA Kit

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EUR 666.67

Mouse Serpin B6 (SERPINB6) ELISA Kit

abx515610-96tests 96 tests
EUR 886.8

Mouse Serpin B5 (SERPINB5) ELISA Kit

abx515646-96tests 96 tests
EUR 801.6

Mouse Serpin H1(SERPINH1) ELISA kit

E03S0361-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin H1(SERPINH1) ELISA kit

E03S0361-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin H1(SERPINH1) ELISA kit

E03S0361-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin B5, Serpinb5 ELISA KIT

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EUR 1038

Mouse Serpinh1/ Serpin H1 ELISA Kit

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EUR 685.2

Mouse Serpin A9, Serpina9 ELISA KIT

ELI-29108m 96 Tests
EUR 1038

Mouse Serpin B6, Serpinb6 ELISA KIT

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Mouse Serpin I2, Serpini2 ELISA KIT

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Mouse Serpin B7, Serpinb7 ELISA KIT

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Mouse Serpin B8, Serpinb8 ELISA KIT

ELI-13938m 96 Tests
EUR 1038

Mouse Serpin B6 (SERPINB6) ELISA Kit

RK13896 96T
EUR 280

Mouse Serpin B5 (SERPINB5) ELISA Kit

RK07808 96T
EUR 280

Mouse Serpin H1 (SERPINH1) ELISA Kit

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EUR 280

Mouse Serpin A12 (SERPINA12) ELISA Kit

abx513785-96tests 96 tests
EUR 801.6

Mouse Serpin B13 (SERPINB13) ELISA Kit

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EUR 801.6

Mouse Serpin A11 (SERPINA11) ELISA Kit

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Mouse Serpin B10 (SERPINB10) ELISA Kit

abx556075-96tests 96 tests
EUR 801.6

Mouse Serpin B10(SERPINB10) ELISA kit

E03S0360-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Serpin B10(SERPINB10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin B10(SERPINB10) ELISA kit

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EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Serpin B10(SERPINB10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin B10(SERPINB10) ELISA kit

E03S0360-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Serpin B10(SERPINB10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin A12, Serpina12 ELISA KIT

ELI-02462m 96 Tests
EUR 1038

Mouse Serpina11/ Serpin A11 ELISA Kit

E1326Mo 1 Kit
EUR 758.4

Mouse Serpina12/ Serpin A12 ELISA Kit

E1327Mo 1 Kit
EUR 685.2

Mouse Serpinb13/ Serpin B13 ELISA Kit

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EUR 758.4

Mouse Serpin A11, Serpina11 ELISA KIT

ELI-41407m 96 Tests
EUR 1038

Mouse Serpin B12, Serpinb12 ELISA KIT

ELI-18716m 96 Tests
EUR 1038

Mouse Serpin B11, Serpinb11 ELISA KIT

ELI-20036m 96 Tests
EUR 1038

Mouse Serpin B13, Serpinb13 ELISA KIT

ELI-20037m 96 Tests
EUR 1038

Mouse Serpin A10 (SERPINA10) ELISA Kit

EKN48066-48T 48T
EUR 389.62

Mouse Serpin A10 (SERPINA10) ELISA Kit

EKN48066-5x96T 5x96T
EUR 2643.85

Mouse Serpin A10 (SERPINA10) ELISA Kit

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EUR 556.6

Mouse Serpin B13 (SERPINB13) ELISA Kit

RK13595 96T
EUR 280

Mouse Serpin A11 (SERPINA11) ELISA Kit

RK13652 96T
EUR 280

Mouse Serpin B12 (SERPINB12) ELISA Kit

RK13720 96T
EUR 280

Mouse Serpin A10 (SERPINA10) ELISA Kit

EKU06955-48T 48T
EUR 571.55

Mouse Serpin A10 (SERPINA10) ELISA Kit

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EUR 3878.38

Mouse Serpin A10 (SERPINA10) ELISA Kit

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EUR 816.5

Human Serpin C1/Antithrombin-III PicoKine ELISA Kit

EK1393 96 wells
EUR 510
Description: For quantitative detection of human Serpin C1 in cell culture supernates, serum, plasma (heparin, EDTA, citrate) and urine.

Mouse SERPINB10 (Serpin B10) ELISA Kit (CUSTOM)

ELI-30152m 96 Tests
EUR 1038

Recombinant Human Serpin C1/Antithrombin III/ATIII Protein

RP00140 20 μg
EUR 423.6

Recombinant Mouse Serpin F1 Protein

RP01582 20μg
EUR 208

Serpina11 ELISA Kit| Mouse Serpin A11 ELISA Kit

EF016180 96 Tests
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Serpinb10 ELISA Kit| Mouse Serpin B10 ELISA Kit

EF016181 96 Tests
EUR 826.8

Mouse Serpin D1 PicoKine ELISA Kit

EK1969 96 wells
EUR 510
Description: For quantitative detection of mouse Serpin D1 in cell culture supernates, serum and plasma (EDTA, citrate) and urine.

Mouse Maspin(serpin B5) ELISA kit

E03M0026-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Maspin(serpin B5) ELISA kit

E03M0026-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Maspin(serpin B5) ELISA kit

E03M0026-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Recombinant Human Serpin G1/C1 Inhibitor (C-6His)

C539-10ug 10ug
EUR 187.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

Recombinant Human Serpin G1/C1 Inhibitor (C-6His)

C539-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

Recombinant Human Serpin G1/C1 Inhibitor (C-6His)

C539-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

Recombinant Human Serpin G1/C1 Inhibitor (C-6His)

C539-50ug 50ug
EUR 442.8
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

Recombinant Mouse Serpin E2 (C-10His)

CU57-10ug 10ug
EUR 157.2
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0.

Recombinant Mouse Serpin E2 (C-10His)

CU57-1mg 1mg
EUR 2008.8
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0.

Recombinant Mouse Serpin E2 (C-10His)

CU57-500ug 500ug
EUR 1399.2
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0.

Recombinant Mouse Serpin E2 (C-10His)

CU57-50ug 50ug
EUR 327.6
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0.

Mouse Serpin E1/PAI-1 ELISA KIT

E42EM-048 96T/48T Ask for price

Nori® Mouse Serpin A3N ELISA Kit

GR117460 96-well
EUR 461

Recombinant Human Serpin G1/C1 inhibitor/C1IN Protein

RP00197 10 μg
EUR 168

Mouse Serpin A1/AAT PicoKine ELISA Kit

EK1711 96 wells
EUR 510
Description: For quantitative detection of mouse AAT in cell culture supernates, serum and plasma (heparin, EDTA).

Nori® Mouse Serpin F2/A2AP ELISA Kit

GR117244 96-well
EUR 461

Human Serpin C1/Antithrombin-III PicoKine™ Fast ELISA Kit

FEK1393 96 wells
EUR 570
Description: The Fast version of Picokine ELISA kits, assay takes less than 1.5 hours. Detect Human Antithrombin Iii/SERPINC1 with <10pg/ml sensitivity. Format: 96-well plate with removable strips. Compatible samples: cell culture supernates, serum, plasma (heparin, EDTA, citrate) and urine. This is a TMB colorimetric sandwich ELISA kit with short assay time and fast experiment set up. Antithrombin Iii/SERPINC1 tissue specificity: Found in plasma.

Recombinant Human Serpin C1/Antithrombin III/ATIII Protein, His Tag

E40KMP1137 20ug
EUR 495

Recombinant Mouse Serpin A1a (C-6His, AH11040.1 )

EPT200 50ug
EUR 725.4
Description: Recombinant Mouse Serine protease inhibitor A1a is produced by our Mammalian expression system and the target gene encoding Glu25-Lys413 is expressed with a 6His tag at the C-terminus.

Mouse Plasma protease C1 inhibitor (Serping1)

1-CSB-EP021086MO
  • EUR 606.00
  • EUR 318.00
  • EUR 2192.40
  • EUR 919.20
  • EUR 1461.60
  • EUR 402.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Plasma protease C1 inhibitor(Serping1),partial expressed in E.coli

Nori® Mouse Serpin E1/PAI-1 ELISA Kit

GR117033 96-well
EUR 461

Serpin B6 (SERPINB6) Antibody

20-abx135864
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Serpin B8 (SERPINB8) Antibody

20-abx210287
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Serpin B6 (SERPINB6) Antibody

abx237747-100ug 100 ug
EUR 610.8

Serpin B8 (SERPINB8) Antibody

abx237748-100ug 100 ug
EUR 610.8

Serpin B9 (SERPINB9) Antibody

abx237749-100ug 100 ug
EUR 610.8

Serpin D1 (SERPIND1) Antibody

abx237750-100ug 100 ug
EUR 610.8

Serpin I2 (SERPINI2) Antibody

abx237754-100ug 100 ug
EUR 610.8

Serpin A8 (SERPINA8) Antibody

20-abx225020
  • EUR 444.00
  • EUR 727.20
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 50 ul

Serpin B3 (SERPINB3) Antibody

20-abx110205
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Serpin B6 (SERPINB6) Antibody

20-abx210574
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Serpin B6 (SERPINB6) Antibody

20-abx210575
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Serpin B3 (SERPINB3) Antibody

20-abx211337
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Serpin B3 (SERPINB3) Antibody

20-abx211338
  • EUR 493.20
  • EUR 360.00
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  • 50 ul

Serpin A1 (SERPINA1) Antibody

20-abx133762
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Serpin A3 (SERPINA3) Antibody

20-abx133770
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Serpin B4 (SERPINB4) Antibody

abx122028-100ug 100 ug
EUR 469.2

Serpin B8 (SERPINB8) Antibody

abx122029-100ug 100 ug
EUR 469.2

Serpin A5 (SERPINA5) Antibody

abx147936-100ug 100 ug
EUR 526.8

Serpin H1 (SERPINH1) Antibody

20-abx321407
  • EUR 360.00
  • EUR 292.80
  • 100 ul
  • 50 ul

Serpin B5 (SERPINB5) Antibody

20-abx321461
  • EUR 360.00
  • EUR 292.80
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  • 50 ul

Serpin B9 (SERPINB9) Antibody

20-abx321527
  • EUR 360.00
  • EUR 292.80
  • 100 ul
  • 50 ul

Serpin B5 (SERPINB5) Antibody

20-abx321596
  • EUR 360.00
  • EUR 292.80
  • 100 ul
  • 50 ul

Serpin B6 (SERPINB6) Antibody

20-abx322087
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Serpin B6 (SERPINB6) Antibody

20-abx322088
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Serpin B9 (SERPINB9) Antibody

abx330656-100ul 100 ul
EUR 510

Serpin B5 (SERPINB5) Antibody

20-abx115469
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Serpin B6 (SERPINB6) Antibody

20-abx115470
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Serpin B8 (SERPINB8) Antibody

20-abx115471
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Serpin B9 (SERPINB9) Antibody

20-abx115472
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Serpin H1 (SERPINH1) Antibody

20-abx115477
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Serpin I2 (SERPINI2) Antibody

20-abx115479
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Serpin B9 (SERPINB9) Antibody

abx031295-400ul 400 ul
EUR 627.6

Serpin B9 (SERPINB9) Antibody

abx031295-80l 80 µl
EUR 343.2

Serpin B8 (SERPINB8) Antibody

abx031365-400ul 400 ul
EUR 627.6

Serpin B8 (SERPINB8) Antibody

abx031365-80l 80 µl
EUR 343.2

Serpin A9 (SERPINA9) Antibody

abx025186-100ul 100 ul
EUR 627.6

Serpin A9 (SERPINA9) Antibody

abx025187-400ul 400 ul
EUR 627.6

Serpin A9 (SERPINA9) Antibody

abx025187-80l 80 µl
EUR 343.2

Serpin B5 (SERPINB5) Antibody

20-abx014060
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Serpin B6 (SERPINB6) Antibody

abx036087-100ug 100 ug
EUR 469.2

Serpin B9 (SERPINB9) Antibody

abx036128-100ug 100 ug
EUR 469.2

Serpin I2 (SERPINI2) Antibody

abx029696-400ul 400 ul
EUR 627.6

Serpin I2 (SERPINI2) Antibody

abx029696-80l 80 µl
EUR 343.2

Serpin H1 (SERPINH1) Antibody

abx033355-400ul 400 ul
EUR 627.6

Serpin H1 (SERPINH1) Antibody

abx033355-80l 80 µl
EUR 343.2

Serpin H1 (SERPINH1) Antibody

abx033356-400ul 400 ul
EUR 627.6

Serpin H1 (SERPINH1) Antibody

abx033356-80l 80 µl
EUR 343.2

Serpin B5 (SERPINB5) Antibody

abx038026-100ug 100 ug
EUR 469.2

Serpin B5 (SERPINB5) Antibody

20-abx127043
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Serpin B8 (SERPINB8) Antibody

20-abx127044
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Serpin I2 (SERPINI2) Antibody

20-abx124373
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Serpin I2 (SERPINI2) Antibody

20-abx126534
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Serpin B3 (SERPINB3) Antibody

20-abx323774
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Serpin B4 (SERPINB4) Antibody

20-abx324075
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Serpin B9 (SERPINB9) Antibody

20-abx328658
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Serpin B4 (SERPINB4) Antibody

20-abx334404
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Serpin D1 (SERPIND1) Antibody

20-abx320675
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Serpin B8 (SERPINB8) Antibody

20-abx339453
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Serpin H1 (Serpinh1) Antibody

20-abx319337
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Serpin B9 (SERPINB9) Antibody

abx431610-200ul 200 ul
EUR 460.8

Serpin B6 (SERPINB6) Antibody

abx433266-200ul 200 ul
EUR 460.8

Serpin B9 (SERPINB9) Antibody

abx414334-01mg 0.1 mg
EUR 526.8

Serpin H1 (SERPINH1) Antibody

20-abx001958
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Serpin A3 (SERPINA3) Antibody

20-abx007897
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Serpin B7 (SERPINB7) Antibody

20-abx008498
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Serpin B4 (SERPINB4) Antibody

20-abx008735
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Serpin B9 (SERPINB9) Antibody

20-abx008866
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Serpin B5 (SERPINB5) Antibody

20-abx008867
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Serpin A1 (SERPINA1) Antibody

20-abx008868
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Serpin B5 (SERPINB5) Antibody

20-abx001093
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Serpin B3 (SERPINB3) Antibody

20-abx004151
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Serpin D1 (SERPIND1) Antibody

20-abx004485
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Serpin B9 (SERPINB9) Antibody

20-abx004888
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Serpin B4 (SERPINB4) Antibody

20-abx014873
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Serpin B9 (SERPINB9) Antibody

20-abx014874
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

SERPINA4 (Serpin A4) Antibody

20-abx142217
  • EUR 444.00
  • EUR 727.20
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 50 ul

Serpin G1 (SERPING1) Antibody

20-abx142218
  • EUR 444.00
  • EUR 727.20
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 50 ul

Serpin B8 (SERPINB8) Antibody

20-abx302456
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Nori® Mouse Serpin A4/Kallistatin ELISA Kit

GR117263 96-well
EUR 461

Serpin A12 (SERPINA12) Antibody

20-abx210286
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Serpin B12 (SERPINB12) Antibody

abx237744-100ug 100 ug
EUR 661.2

Serpin B13 (SERPINB13) Antibody

abx237745-100ug 100 ug
EUR 610.8

Serpin A11 (SERPINA11) Antibody

abx218523-100ug 100 ug
EUR 526.8

Serpin B12 (SERPINB12) Antibody

abx218524-100ug 100 ug
EUR 526.8

Serpin A11 (SERPINA11) Antibody

20-abx213899
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Serpin A11 (SERPINA11) Antibody

20-abx213900
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Serpin A12 (SERPINA12) Antibody

20-abx210572
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Serpin B12 (SERPINB12) Antibody

20-abx115466
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Serpin B13 (SERPINB13) Antibody

20-abx115467
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Serpin B12 (SERPINB12) Antibody

abx030254-400ul 400 ul
EUR 627.6

Serpin B12 (SERPINB12) Antibody

abx030254-80l 80 µl
EUR 343.2

Serpin B12 (SERPINB12) Antibody

20-abx323469
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Serpin A11 (SERPINA11) Antibody

20-abx323960
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Serpin A11 (SERPINA11) Antibody

20-abx338580
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Serpin A12 (SERPINA12) Antibody

20-abx320572
  • EUR 360.00
  • EUR 292.80
  • 100 ul
  • 50 ul

Serpin A12 (SERPINA12) Antibody

abx433262-200ul 200 ul
EUR 460.8

Serpin A12 (SERPINA12) Antibody

20-abx006608
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Serpin B12 (SERPINB12) Antibody

20-abx308929
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mouse Serpin F2 Recombinant Protein C-Fc Tag

IMSSERPINF2RCFC50UG each
EUR 1029
Description: Mouse Serpin F2 Recombinant Protein C-Fc Tag

Serpin A3

MO15082 500 ug
EUR 615.6

Serpin E1

E21-537 10ug
EUR 411.6

Serpin F1

E21-538 10ug
EUR 411.6
Key findings: AEBN induced carcinogenesis primarily within the liver by considerably impairing AMPK signaling, inducing oxidative stress, activating Akt/mTOR signaling, growing Ki-67 immunoreactivity and cyclin D1 expression, and considerably diminishing apoptosis. Co-administration of AEBN with vildagliptin (10 mg kg-1 physique weight) for eight weeks lowered liver dysplasia, and considerably decreased free palmitic acid, elevated free oleic acid, normalized lipid profile, decreased oxidative stress, cyclin D1 expression, Ki-67 immunoreactivity, and Bcl2 expression, and elevated the ratio of apoptotic/non-apoptotic cells. Mechanistically, vildagliptin elicited these physiological and molecular alterations by restoring regular AMPK signaling and decreasing the mobile expressions of FASN and HMGCR, restoring AMPK-dependent phosphorylation of p53 at Ser-15 and decreasing Akt/mTOR signaling.