Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

December 22, 2020 0 By Keith

Intramembrane proteases (IMPs) are a novel class of proteases that catalyze the proteolysis inside the membrane and regulate numerous mobile processes in numerous organisms. RseP, an Escherichia coli site-2 protease (S2P) household IMP, is concerned within the regulation of an extracytoplasmic stress response via the cleavage of membrane-spanning anti-stress-response transcription issue (anti-σE) protein RseA. Extracytoplasmic stresses set off a sequential cleavage of RseA, by which first DegS cleaves off its periplasmic area, and RseP catalyzes the second cleavage of RseA. The 2 tandem-arranged periplasmic PDZ (PDZ tandem) domains of RseP function a size-exclusion filter which prevents the entry of an intact RseA into the energetic website of RseP IMP area. Nevertheless, RseP’s substrate recognition mechanism is just not absolutely understood.

Right here, we discovered {that a} periplasmic area of RseP, situated downstream of the PDZ tandem, comprises a phase (named H1) predicted to kind an amphiphilic helix. Bacterial S2P homologs with numerous numbers of PDZ domains have the same amphiphilic helix within the corresponding area. We demonstrated that the H1 phase types {a partially} membrane-embedded amphiphilic helix on the periplasmic floor of the membrane.

Systematic and random mutagenesis analyses revealed that the H1 helix is necessary for the soundness and proteolytic operate of RseP and that mutations within the H1 phase can have an effect on the PDZ-mediated substrate discrimination. Cross-linking experiments urged that H1 instantly interacts with the DegS-cleaved type of RseA. We suggest that H1 acts as an adaptor required for correct association of the PDZ tandem area to carry out its filter operate and for substrate positioning for its environment friendly cleavage.

 

Tripeptidyl peptidase I promotes human endometrial epithelial cell adhesive capability implying a job in receptivity

The endometrium undergoes cyclic remodelling all through the menstrual cycle in preparation for embryo implantation which happens in a brief window through the mid-secretory part. It’s throughout this quick ‘receptive window’ that the endometrial luminal epithelium acquires adhesive capability allowing blastocysts agency adhesion to the endometrium to determine being pregnant. Dysregulation in any of those steps can compromise embryo implantation leading to implantation failure and infertility. Many elements contribute to those processes together with and proteases.
Tripeptidyl peptidase 1  is a is a lysosomal serine-type protease nevertheless the contribution of the TPP1 to receptivity is unknown. We aimed to research the function of receptivity in people.Within the present research, TPP1 was expressed in each epithelial and stromal compartments of the endometrium throughout the menstrual cycle. Expression was confined to the cytoplasm of luminal and glandular epithelial cells and stromal cells. Staining of mid-secretory endometrial tissues of ladies with regular fertility and first unexplained infertility confirmed lowered immunostaining depth of TPP1 in luminal epithelial cells of infertile tissues in comparison with fertile tissues.
In contrast, TPP1 ranges in glandular epithelial and stromal cells had been comparable in each teams within the mid-secretory part. Inhibition of TPP1 utilizing siRNA compromised HTR8/SVneo (trophoblast cell line) spheroid adhesion on siRNA-transfected Ishikawa cells (endometrial epithelial cell line) in vitro. This impairment was related to decreased sirtuin 1 (SIRT1), BCL2 and p53 mRNA and unaltered and LIF receptor gene expression between remedy teams. siRNA knockdown of TPP1 in main human endometrial stromal cells didn’t have an effect on decidualization nor the expression of decidualization markers prolactin (PRL) and insulin-like development factor-binding protein 1 (IGFBP1). Taken collectively, our knowledge strongly suggests a job for TPP1 in endometrial receptivity by way of its results on epithelial cell adhesion and suggests lowered ranges related to unexplained infertility might contribute to implantation failure.
 Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

Vildagliptin, a dipeptidyl peptidase-Four inhibitor, reduces betel-nut induced carcinogenesis in feminine mice

Purpose: Betel-nut, a well-liked masticatory amongst Southeast Asian populations is a category I carcinogen, beforehand related to dyslipidemia and aberrant lipid metabolism, and is reported for use extra regularly by females, than males. This research investigates the potential of repurposing the anti-diabetic drug, vildagliptin, a dipeptidyl peptidase-Four inhibitor, for assuaging the oncogenic situation in feminine Swiss Albino mice administered an aqueous extract of betel-nut (AEBN) orally (2 mg ml-1) for 24 weeks.
Primarystrategies: Tissues had been investigated by histopathological, immunohistochemical and apoptosis assays. Biochemical analyses of oxidative stress markers and lipid profile had been carried out utilizing completely different tissues and sera. The expressions of various proteins concerned in lipid metabolism and oncogenic pathways had been evaluated by Western blotting.

Recombinant Mouse Serpin G1/C1 Inhibitor (C-6His)

CJ07-50ug 50ug
EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl,pH8.0.

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 418.8

Recombinant Human Serpin G1/C1 Inhibitor (C-6His)

C539-10ug 10ug
EUR 187.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

Recombinant Human Serpin G1/C1 Inhibitor (C-6His)

C539-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

Recombinant Human Serpin G1/C1 Inhibitor (C-6His)

C539-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

Recombinant Human Serpin G1/C1 Inhibitor (C-6His)

C539-50ug 50ug
EUR 442.8
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

Human Serpin C1/Antithrombin-III PicoKine ELISA Kit

EK1393 96 wells
EUR 510
Description: For quantitative detection of human Serpin C1 in cell culture supernates, serum, plasma (heparin, EDTA, citrate) and urine.

Recombinant Human Serpin C1/Antithrombin III/ATIII Protein

RP00140 20 μg
EUR 423.6

Recombinant Human Serpin G1/C1 inhibitor/C1IN Protein

RP00197 10 μg
EUR 168

anti-C1 Inactivator

YF-PA23327 50 ul
EUR 400.8
Description: Mouse polyclonal to C1 Inactivator

anti-plexin C1

YF-PA25496 50 ul
EUR 400.8
Description: Mouse polyclonal to plexin C1

anti-C1 Inactivator

YF-PA10543 50 ug
EUR 435.6
Description: Mouse polyclonal to C1 Inactivator

anti-C1 Inactivator

YF-PA10544 100 ug
EUR 483.6
Description: Rabbit polyclonal to C1 Inactivator

Human Serpin C1/Antithrombin-III PicoKine™ Fast ELISA Kit

FEK1393 96 wells
EUR 570
Description: The Fast version of Picokine ELISA kits, assay takes less than 1.5 hours. Detect Human Antithrombin Iii/SERPINC1 with <10pg/ml sensitivity. Format: 96-well plate with removable strips. Compatible samples: cell culture supernates, serum, plasma (heparin, EDTA, citrate) and urine. This is a TMB colorimetric sandwich ELISA kit with short assay time and fast experiment set up. Antithrombin Iii/SERPINC1 tissue specificity: Found in plasma.

Anti-Serpin B12 Antibody

A13578 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Serpin B12 Antibody (SERPINB12) detection. Tested with WB in Human.

Anti-Serpin A11 antibody

STJ95622 200 µl
EUR 236.4
Description: Rabbit polyclonal to Serpin A11.

Anti-Serpin B12 antibody

STJ95623 200 µl
EUR 236.4
Description: Rabbit polyclonal to Serpin B12.

Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E03C0353-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E03C0353-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E03C0353-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 336

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 336

Anti-Cytochrome c1 Antibody

A02958 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Cytochrome c1 Antibody (CYC1) detection. Tested with WB in Human, Mouse.

Anti-Cytochrome c1 antibody

STJ92623 200 µl
EUR 236.4
Description: Rabbit polyclonal to Cytochrome c1.

Anti-plexin C1 (1A12)

YF-MA17154 100 ug
EUR 435.6
Description: Mouse monoclonal to plexin C1

Anti-DNAJB6 (2C11-C1)

YF-MA11237 100 ug
EUR 435.6
Description: Mouse monoclonal to DNAJB6

Mouse Apolipoprotein C1 (APO-C1) CLIA Kit

abx196721-96tests 96 tests
EUR 990

Mouse APO-C1(Apolipoprotein C1) ELISA Kit

EM0844 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 37.5 ng/ml

Mouse Serpin H1 (Serpinh1)

1-CSB-EP021087MO
  • EUR 606.00
  • EUR 318.00
  • EUR 2192.40
  • EUR 919.20
  • EUR 1461.60
  • EUR 402.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Serpin H1(Serpinh1) expressed in E.coli

Mouse Serpin H1 (Serpinh1)

1-CSB-YP021087MO
  • EUR 604.80
  • EUR 318.00
  • EUR 2198.40
  • EUR 915.60
  • EUR 1459.20
  • EUR 400.80
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Serpin H1(Serpinh1) expressed in Yeast

CLIA kit for Mouse APO-C1 (Apolipoprotein C1)

E-CL-M0099 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Mouse APO-C1 (Apolipoprotein C1) in samples from Serum, Plasma, Cell supernatant

Anti-hnRNP C1/C2 Antibody

A02726 100ul
EUR 476.4
Description: Rabbit Polyclonal hnRNP C1/C2 Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-hnRNP C1/2 antibody

STJ93559 200 µl
EUR 236.4
Description: Rabbit polyclonal to hnRNP C1/2.

Anti-hnRNP C1/C2 antibody

STJ93560 200 µl
EUR 236.4
Description: Rabbit polyclonal to hnRNP C1/C2.

Anti-C1 Inactivator (3F4-1D9)

YF-MA10108 100 ug
EUR 435.6
Description: Mouse monoclonal to C1 Inactivator

Anti-Niemann Pick C1 (4H2)

YF-MA10640 100 ug
EUR 435.6
Description: Mouse monoclonal to Niemann Pick C1

Anti-Stefin B (M1-C1)

YF-MA12592 100 ug
EUR 435.6
Description: Mouse monoclonal to Stefin B

Serpin A3

MO15082 500 ug
EUR 615.6

Serpin E1

E21-537 10ug
EUR 411.6

Serpin F1

E21-538 10ug
EUR 411.6

Goat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E06C0353-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E06C0353-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E06C0353-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E04C0353-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E04C0353-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E04C0353-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E01C0353-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E01C0353-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E01C0353-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E02C0353-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E02C0353-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E02C0353-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E07C0353-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E07C0353-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E07C0353-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E08C0353-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E08C0353-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E08C0353-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E09C0353-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E09C0353-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E09C0353-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

APO-C1 ELISA Kit| Mouse Apolipoprotein C1 ELISA Kit

EF013446 96 Tests
EUR 826.8

Guinea pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E05C0353-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Guinea pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E05C0353-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Guinea pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E05C0353-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Guinea pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Anti-Niemann Pick C1/NPC1 Antibody

A00428-2 100ug/vial
EUR 352.8

Anti-Calicheamicin monoclonal antibody (clone c1)

ADC-AD-011 50 μg
EUR 3528
Description: A mouse monoclonal antibody (clone c1) which specifically againsts the payload Calicheamicin. This product is for research purposes only, not for use in diagnostics.

Sal O Anti Grp C1 3Ml

229491 EACH
EUR 119.7

Mouse Anti-Ovalbumin IgE Monoclonal Antibody, Clone E-C1

7091 1 mg/ml x 0.1 ml
EUR 406.26
Description: Mouse Anti-Ovalbumin IgE Monoclonal Antibody

SKPin C1

2343-25
EUR 502.8

SKPin C1

2343-5
EUR 170.4

Bafilomycin C1

B042-1MG 1 mg
EUR 268.8

Bafilomycin C1

B042-5MG 5 mg
EUR 849.6

Bafilomycin C1

C4729-1 1 mg
EUR 290.4

Bafilomycin C1

C4729-5 5 mg
EUR 1105.2

Gad c1

LF-P0522 0.1 mg
EUR 420
Description: Gad c1 protein

Gad c1

LF-P0522A 0.5 mg
EUR 1496.4
Description: Gad c1 protein

Gad c1

LF-P0522B 1 mg
EUR 2397.6
Description: Gad c1 protein

Bafilomycin C1

GA5404-1MG 1 mg
EUR 274.8

Procyanidin C1

HY-N2342 10mg
EUR 817.2

Sinocrassoside C1

TBW01629 5mg Ask for price

Ciwujianoside C1

TBZ0180 unit Ask for price

Combretastatin C1

TBZ1182 unit Ask for price

Proanthocyanidin C1

TBZ2552 10mg Ask for price

pDsRed1- C1

PVT10761 2 ug
EUR 361.2

pmScarlet- C1

PVT10762 2 ug
EUR 361.2

pHcRed1- C1

PVT10767 2 ug
EUR 319.2

pmCitrine- C1

PVT10776 2 ug
EUR 361.2

pmVenus- C1

PVT10777 2 ug
EUR 361.2

pEBFP2-C1

PVT14110 2 ug
EUR 843.6

pTurboRFP-C1

PVT14117 2 ug
EUR 843.6

pEYFP-C1

PVT14506 2 ug
EUR 843.6

Mouse Apolipoprotein C1 (APOC1) Protein

20-abx065418
  • EUR 777.60
  • EUR 326.40
  • EUR 2331.60
  • EUR 910.80
  • EUR 560.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Plexin C1 ELISA kit

E03P1025-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Plexin C1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Plexin C1 ELISA kit

E03P1025-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Plexin C1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Plexin C1 ELISA kit

E03P1025-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Plexin C1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Apolipoprotein C1 ELISA kit

E03A0514-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Apolipoprotein C1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Apolipoprotein C1 ELISA kit

E03A0514-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Apolipoprotein C1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Apolipoprotein C1 ELISA kit

E03A0514-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Apolipoprotein C1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Serpin A6 antibody

70R-12181 100 ug
EUR 483.6
Description: Rabbit polyclonal Serpin A6 antibody

Serpin A1 antibody

70R-50204 100 ul
EUR 292.8
Description: Purified Polyclonal Serpin A1 antibody

Serpin B5 antibody

70R-50205 100 ul
EUR 292.8
Description: Purified Polyclonal Serpin B5 antibody

Serpin B9 antibody

70R-50206 100 ul
EUR 292.8
Description: Purified Polyclonal Serpin B9 antibody

Serpin B4 antibody

70R-50366 100 ul
EUR 292.8
Description: Purified Polyclonal Serpin B4 antibody

Serpin B7 antibody

70R-50630 100 ul
EUR 292.8
Description: Purified Polyclonal Serpin B7 antibody

Serpin B5 antibody

70R-33858 100 ug
EUR 392.4
Description: Rabbit polyclonal Serpin B5 antibody

Serpin A6 Antibody

3906-100
EUR 379.2

Serpin A6 Antibody

3906-30T
EUR 175.2

Serpin B12 Antibody

47983-100ul 100ul
EUR 302.4

Serpin B5 Antibody

34298-100ul 100ul
EUR 302.4

Serpin B5 Antibody

34298-50ul 50ul
EUR 224.4

Serpin A5 Antibody

34908-100ul 100ul
EUR 302.4

Serpin A5 Antibody

34908-50ul 50ul
EUR 224.4

Serpin A5 Antibody

ABD4300 100 ug
EUR 525.6

Serpin A5 Antibody

DF4300 200ul
EUR 420

Mouse Serpin A12 (SERPINA12) ELISA Kit

abx513785-96tests 96 tests
EUR 801.6

Mouse Serpin B6 (SERPINB6) ELISA Kit

abx515610-96tests 96 tests
EUR 886.8

Mouse Serpin B5 (SERPINB5) ELISA Kit

abx515646-96tests 96 tests
EUR 801.6

Mouse Serpin B13 (SERPINB13) ELISA Kit

abx517379-96tests 96 tests
EUR 801.6

Mouse Serpin A11 (SERPINA11) ELISA Kit

abx520863-96tests 96 tests
EUR 886.8

Mouse Serpin B10 (SERPINB10) ELISA Kit

abx556075-96tests 96 tests
EUR 801.6

Recombinant Mouse Serpin E2 (C-10His)

CU57-10ug 10ug
EUR 157.2
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0.

Recombinant Mouse Serpin E2 (C-10His)

CU57-1mg 1mg
EUR 2008.8
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0.

Recombinant Mouse Serpin E2 (C-10His)

CU57-500ug 500ug
EUR 1399.2
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0.

Recombinant Mouse Serpin E2 (C-10His)

CU57-50ug 50ug
EUR 327.6
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0.

Mouse Maspin(serpin B5) ELISA kit

E03M0026-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Maspin(serpin B5) ELISA kit

E03M0026-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Maspin(serpin B5) ELISA kit

E03M0026-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin B10(SERPINB10) ELISA kit

E03S0360-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Serpin B10(SERPINB10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin B10(SERPINB10) ELISA kit

E03S0360-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Serpin B10(SERPINB10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin B10(SERPINB10) ELISA kit

E03S0360-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Serpin B10(SERPINB10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin H1(SERPINH1) ELISA kit

E03S0361-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin H1(SERPINH1) ELISA kit

E03S0361-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin H1(SERPINH1) ELISA kit

E03S0361-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin D1 PicoKine ELISA Kit

EK1969 96 wells
EUR 510
Description: For quantitative detection of mouse Serpin D1 in cell culture supernates, serum and plasma (EDTA, citrate) and urine.

Mouse Serpina11/ Serpin A11 ELISA Kit

E1326Mo 1 Kit
EUR 758.4

Mouse Serpina12/ Serpin A12 ELISA Kit

E1327Mo 1 Kit
EUR 685.2

Mouse Serpinb13/ Serpin B13 ELISA Kit

E1330Mo 1 Kit
EUR 758.4

Mouse Serpinh1/ Serpin H1 ELISA Kit

E1335Mo 1 Kit
EUR 685.2

Mouse Serpin B6, Serpinb6 ELISA KIT

ELI-40953m 96 Tests
EUR 1038

Mouse Serpin A11, Serpina11 ELISA KIT

ELI-41407m 96 Tests
EUR 1038

Mouse Serpin B12, Serpinb12 ELISA KIT

ELI-18716m 96 Tests
EUR 1038

Mouse Serpin B7, Serpinb7 ELISA KIT

ELI-19120m 96 Tests
EUR 1038

Mouse Serpin B11, Serpinb11 ELISA KIT

ELI-20036m 96 Tests
EUR 1038

Mouse Serpin B13, Serpinb13 ELISA KIT

ELI-20037m 96 Tests
EUR 1038

Mouse Serpin A9, Serpina9 ELISA KIT

ELI-29108m 96 Tests
EUR 1038

Mouse Serpin A12, Serpina12 ELISA KIT

ELI-02462m 96 Tests
EUR 1038

Mouse Serpin B5, Serpinb5 ELISA KIT

ELI-03909m 96 Tests
EUR 1038

Mouse Serpin B8, Serpinb8 ELISA KIT

ELI-13938m 96 Tests
EUR 1038

Mouse Serpin I2, Serpini2 ELISA KIT

ELI-18265m 96 Tests
EUR 1038

Human Anti-Mouse IgG (HAMA) positive control (for use with #200-205-HAM)

200-208-C1 1 ml
EUR 270

Anti-hnRNP C1/C2 Rabbit Monoclonal Antibody

M02726 100ug/vial
EUR 476.4
Description: Rabbit Monoclonal hnRNP C1/C2 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

Anti-Phospho-hnRNP C1/2 (S260) antibody

STJ90910 200 µl
EUR 236.4
Description: Rabbit polyclonal to Phospho-hnRNP C1/2 (S260).

Mouse Serum albumin control (level 1 ~ 1ug/ml) for ELISA

6300-C1 1 ml
EUR 169.2

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

20-abx153662
  • EUR 7970.40
  • EUR 4250.40
  • EUR 990.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

abx255189-96tests 96 tests
EUR 801.6

Mouse Apolipoprotein C1 (APOC1) CLIA Kit

20-abx491288
  • EUR 9567.60
  • EUR 5095.20
  • EUR 1177.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

abx575875-96tests 96 tests
EUR 801.6

Mouse Plasma protease C1 inhibitor (Serping1)

1-CSB-EP021086MO
  • EUR 606.00
  • EUR 318.00
  • EUR 2192.40
  • EUR 919.20
  • EUR 1461.60
  • EUR 402.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Plasma protease C1 inhibitor(Serping1),partial expressed in E.coli

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

DLR-APOC1-Mu-48T 48T
EUR 586.8
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Apolipoprotein C1 (APOC1) in samples from serum, plasma or other biological fluids.

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

DLR-APOC1-Mu-96T 96T
EUR 762
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Apolipoprotein C1 (APOC1) in samples from serum, plasma or other biological fluids.

Mouse Plexin C1 PicoKine ELISA Kit

EK1829 96 wells
EUR 510
Description: For quantitative detection of mouse Plexin C1 in cell culture supernates, serum and plasma (heparin, EDTA).

Mouse Monofunctional C1- tetrahydrofolate synthase, mitochondria

ELI-24946m 96 Tests
EUR 1038

Mouse Plexin- C1, Plxnc1 ELISA KIT

ELI-37319m 96 Tests
EUR 1038

Apolipoprotein C1 (APOC1) Monoclonal Antibody (Mouse)

4-MAA252Mu21
  • EUR 303.60
  • EUR 3138.00
  • EUR 778.80
  • EUR 382.80
  • EUR 259.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rat monoclonal antibody against Mouse Apolipoprotein C1 (APOC1)

Apolipoprotein C1 (APOC1) Polyclonal Antibody (Mouse)

4-PAA252Mu01
  • EUR 283.20
  • EUR 2805.60
  • EUR 703.20
  • EUR 352.80
  • EUR 250.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Apolipoprotein C1 (APOC1)

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

SEA252Mu-10x96wellstestplate 10x96-wells test plate
EUR 5269.39
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Apolipoprotein C1 (APOC1) in serum, plasma and other biological fluids.

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

SEA252Mu-1x48wellstestplate 1x48-wells test plate
EUR 539.12
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Apolipoprotein C1 (APOC1) in serum, plasma and other biological fluids.

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

SEA252Mu-1x96wellstestplate 1x96-wells test plate
EUR 718.75
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Apolipoprotein C1 (APOC1) in serum, plasma and other biological fluids.

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

SEA252Mu-5x96wellstestplate 5x96-wells test plate
EUR 2874.38
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Apolipoprotein C1 (APOC1) in serum, plasma and other biological fluids.

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

4-SEA252Mu
  • EUR 5330.40
  • EUR 2815.20
  • EUR 718.80
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Apolipoprotein C1 (APOC1) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

RD-APOC1-Mu-48Tests 48 Tests
EUR 586.8

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

RD-APOC1-Mu-96Tests 96 Tests
EUR 812.4

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

RDR-APOC1-Mu-48Tests 48 Tests
EUR 613.2

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

RDR-APOC1-Mu-96Tests 96 Tests
EUR 850.8
Key findings: AEBN induced carcinogenesis primarily within the liver by considerably impairing AMPK signaling, inducing oxidative stress, activating Akt/mTOR signaling, growing Ki-67 immunoreactivity and cyclin D1 expression, and considerably diminishing apoptosis. Co-administration of AEBN with vildagliptin (10 mg kg-1 physique weight) for eight weeks lowered liver dysplasia, and considerably decreased free palmitic acid, elevated free oleic acid, normalized lipid profile, decreased oxidative stress, cyclin D1 expression, Ki-67 immunoreactivity, and Bcl2 expression, and elevated the ratio of apoptotic/non-apoptotic cells. Mechanistically, vildagliptin elicited these physiological and molecular alterations by restoring regular AMPK signaling and decreasing the mobile expressions of FASN and HMGCR, restoring AMPK-dependent phosphorylation of p53 at Ser-15 and decreasing Akt/mTOR signaling.