Intramembrane proteases (IMPs) are a novel class of proteases that catalyze the proteolysis inside the membrane and regulate numerous mobile processes in numerous organisms. RseP, an Escherichia coli site-2 protease (S2P) household IMP, is concerned within the regulation of an extracytoplasmic stress response via the cleavage of membrane-spanning anti-stress-response transcription issue (anti-σE) protein RseA. Extracytoplasmic stresses set off a sequential cleavage of RseA, by which first DegS cleaves off its periplasmic area, and RseP catalyzes the second cleavage of RseA. The 2 tandem-arranged periplasmic PDZ (PDZ tandem) domains of RseP function a size-exclusion filter which prevents the entry of an intact RseA into the energetic website of RseP IMP area. Nevertheless, RseP’s substrate recognition mechanism is just not absolutely understood.
Right here, we discovered {that a} periplasmic area of RseP, situated downstream of the PDZ tandem, comprises a phase (named H1) predicted to kind an amphiphilic helix. Bacterial S2P homologs with numerous numbers of PDZ domains have the same amphiphilic helix within the corresponding area. We demonstrated that the H1 phase types {a partially} membrane-embedded amphiphilic helix on the periplasmic floor of the membrane.
Systematic and random mutagenesis analyses revealed that the H1 helix is necessary for the soundness and proteolytic operate of RseP and that mutations within the H1 phase can have an effect on the PDZ-mediated substrate discrimination. Cross-linking experiments urged that H1 instantly interacts with the DegS-cleaved type of RseA. We suggest that H1 acts as an adaptor required for correct association of the PDZ tandem area to carry out its filter operate and for substrate positioning for its environment friendly cleavage.
Tripeptidyl peptidase I promotes human endometrial epithelial cell adhesive capability implying a job in receptivity
The endometrium undergoes cyclic remodelling all through the menstrual cycle in preparation for embryo implantation which happens in a brief window through the mid-secretory part. It’s throughout this quick ‘receptive window’ that the endometrial luminal epithelium acquires adhesive capability allowing blastocysts agency adhesion to the endometrium to determine being pregnant. Dysregulation in any of those steps can compromise embryo implantation leading to implantation failure and infertility. Many elements contribute to those processes together with and proteases.
Tripeptidyl peptidase 1 is a is a lysosomal serine-type protease nevertheless the contribution of the TPP1 to receptivity is unknown. We aimed to research the function of receptivity in people.Within the present research, TPP1 was expressed in each epithelial and stromal compartments of the endometrium throughout the menstrual cycle. Expression was confined to the cytoplasm of luminal and glandular epithelial cells and stromal cells. Staining of mid-secretory endometrial tissues of ladies with regular fertility and first unexplained infertility confirmed lowered immunostaining depth of TPP1 in luminal epithelial cells of infertile tissues in comparison with fertile tissues.
In contrast, TPP1 ranges in glandular epithelial and stromal cells had been comparable in each teams within the mid-secretory part. Inhibition of TPP1 utilizing siRNA compromised HTR8/SVneo (trophoblast cell line) spheroid adhesion on siRNA-transfected Ishikawa cells (endometrial epithelial cell line) in vitro. This impairment was related to decreased sirtuin 1 (SIRT1), BCL2 and p53 mRNA and unaltered and LIF receptor gene expression between remedy teams. siRNA knockdown of TPP1 in main human endometrial stromal cells didn’t have an effect on decidualization nor the expression of decidualization markers prolactin (PRL) and insulin-like development factor-binding protein 1 (IGFBP1). Taken collectively, our knowledge strongly suggests a job for TPP1 in endometrial receptivity by way of its results on epithelial cell adhesion and suggests lowered ranges related to unexplained infertility might contribute to implantation failure.
Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP
Vildagliptin, a dipeptidyl peptidase-Four inhibitor, reduces betel-nut induced carcinogenesis in feminine mice
Purpose: Betel-nut, a well-liked masticatory amongst Southeast Asian populations is a category I carcinogen, beforehand related to dyslipidemia and aberrant lipid metabolism, and is reported for use extra regularly by females, than males. This research investigates the potential of repurposing the anti-diabetic drug, vildagliptin, a dipeptidyl peptidase-Four inhibitor, for assuaging the oncogenic situation in feminine Swiss Albino mice administered an aqueous extract of betel-nut (AEBN) orally (2 mg ml-1) for 24 weeks.
Primarystrategies: Tissues had been investigated by histopathological, immunohistochemical and apoptosis assays. Biochemical analyses of oxidative stress markers and lipid profile had been carried out utilizing completely different tissues and sera. The expressions of various proteins concerned in lipid metabolism and oncogenic pathways had been evaluated by Western blotting.
Recombinant Mouse Serpin G1/C1 Inhibitor (C-6His) |
CJ07-500ug |
Novoprotein |
500ug |
EUR 1935.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl,pH8.0. |
Recombinant Mouse Serpin G1/C1 Inhibitor (C-6His) |
CJ07-50ug |
Novoprotein |
50ug |
EUR 595.2 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl,pH8.0. |
Recombinant Mouse Serpin G1/C1 Inhibitor (C-6His) |
AP76070 |
SAB |
1mg |
EUR 3489 |
|
Human SERPINC1(Serpin C1) ELISA Kit |
EH0560 |
FN Test |
96T |
EUR 628.92 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375 ng/ml |
Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit |
E01A19696 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Mouse Serpin H1 (Serpinh1) |
1-CSB-YP021087MO |
Cusabio |
-
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- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Mouse Serpin H1(Serpinh1) expressed in Yeast |
Mouse Serpin H1 (Serpinh1) |
1-CSB-EP021087MO |
Cusabio |
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- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Mouse Serpin H1(Serpinh1) expressed in E.coli |
Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit |
E03C0353-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit |
E03C0353-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit |
E03C0353-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Recombinant Mouse Serpin H1(Serpinh1) |
AP72778 |
SAB |
each |
Ask for price |
|
Recombinant Mouse Serpin H1(Serpinh1) |
AP70769 |
SAB |
1mg |
EUR 2826 |
|
Anti-Mouse Serpin E2 Antibody |
103-M469 |
ReliaTech |
100 µg |
EUR 399 |
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins. |
Anti-Mouse Serpin F1 Antibody |
103-M470 |
ReliaTech |
100 µg |
EUR 399 |
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins. |
Anti-Mouse Serpin F2 Antibody |
103-M471 |
ReliaTech |
100 µg |
EUR 399 |
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins. |
Mouse Serpin H1(SERPINH1) ELISA kit |
E01A25401 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Mouse Serpin H1(SERPINH1) ELISA kit |
E03S0361-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Serpin H1(SERPINH1) ELISA kit |
E03S0361-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Serpin H1(SERPINH1) ELISA kit |
E03S0361-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Serpinh1/ Serpin H1 ELISA Kit |
E1335Mo |
Sunlong |
1 Kit |
EUR 543 |
|
Description: Cbp1,Hsp47,47 kDa heat shock protein,Collagen-binding protein,Serine protease inhibitor J6,Colligin |
Mouse Serpinb6 / Serpin B6 ELISA Kit |
E11772m |
EIAab |
96T |
EUR 776 |
Mouse Serpinb5 / Serpin B5 ELISA Kit |
E1183m |
EIAab |
96T |
EUR 776 |
Mouse Serpinh1 / Serpin H1 ELISA Kit |
E0266m |
EIAab |
96T |
EUR 776 |
Mouse Serpin B10(SERPINB10) ELISA kit |
E01A25400 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Mouse Serpin B10(SERPINB10) ELISA kit |
E03S0360-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Serpin B10(SERPINB10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Serpin B10(SERPINB10) ELISA kit |
E03S0360-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Serpin B10(SERPINB10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Serpin B10(SERPINB10) ELISA kit |
E03S0360-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Serpin B10(SERPINB10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Serpina11/ Serpin A11 ELISA Kit |
E1326Mo |
Sunlong |
1 Kit |
EUR 543 |
|
Description: Gm895 |
Mouse Serpina12/ Serpin A12 ELISA Kit |
E1327Mo |
Sunlong |
1 Kit |
EUR 543 |
|
Description: Visceral adipose tissue-derived serine protease inhibitor,Visceral adipose-specific serpin,Vaspin |
Mouse Serpina12 / Serpin A12 ELISA Kit |
E0706m |
EIAab |
96T |
EUR 776 |
Mouse Serpinb13 / Serpin B13 ELISA Kit |
E15007m |
EIAab |
96T |
EUR 776 |
Mouse Serpinb10 / Serpin B10 ELISA Kit |
E15046m |
EIAab |
96T |
EUR 776 |
Mouse Serpina11 / Serpin A11 ELISA Kit |
E8916m |
EIAab |
96T |
EUR 776 |
Mouse Serpinb12 / Serpin B12 ELISA Kit |
E15575m |
EIAab |
96T |
EUR 776 |
Mouse Serpin B8, SERPINB8 GENLISA ELISA |
KLM2462 |
Krishgen |
1 x 96 wells |
EUR 341 |
Human Serpin C1/Antithrombin-III PicoKine ELISA Kit |
EK1393 |
BosterBio |
96 wells |
EUR 510 |
Description: For quantitative detection of human Serpin C1 in cell culture supernates, serum, plasma (heparin, EDTA, citrate) and urine. |
Active Recombinant Human Serpin C1/Antithrombin-III Protein |
RP00140 |
Abclonal |
20 μg |
EUR 942.5 |
|
Recombinant Human Serpin G1/C1 Inhibitor (C-6His) |
AP75237 |
SAB |
1mg |
EUR 3209 |
|
Recombinant Human Serpin G1/C1 Inhibitor (C-6His) |
C539-10ug |
Novoprotein |
10ug |
EUR 187.2 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0. |
Recombinant Human Serpin G1/C1 Inhibitor (C-6His) |
C539-1mg |
Novoprotein |
1mg |
EUR 2739.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0. |
Recombinant Human Serpin G1/C1 Inhibitor (C-6His) |
C539-500ug |
Novoprotein |
500ug |
EUR 1935.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0. |
Recombinant Human Serpin G1/C1 Inhibitor (C-6His) |
C539-50ug |
Novoprotein |
50ug |
EUR 442.8 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0. |
Mouse Serpin D1 PicoKine ELISA Kit |
EK1969 |
BosterBio |
96 wells |
EUR 510 |
Description: For quantitative detection of mouse Serpin D1 in cell culture supernates, serum and plasma (EDTA, citrate) and urine. |
Mouse Maspin(serpin B5) ELISA kit |
E03M0026-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Maspin(serpin B5) ELISA kit |
E03M0026-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Maspin(serpin B5) ELISA kit |
E03M0026-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Recombinant Mouse Serpin E2 (C-10His) |
CU57-10ug |
Novoprotein |
10ug |
EUR 157.2 |
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0. |
Recombinant Mouse Serpin E2 (C-10His) |
CU57-1mg |
Novoprotein |
1mg |
EUR 2008.8 |
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0. |
Recombinant Mouse Serpin E2 (C-10His) |
CU57-500ug |
Novoprotein |
500ug |
EUR 1399.2 |
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0. |
Recombinant Mouse Serpin E2 (C-10His) |
CU57-50ug |
Novoprotein |
50ug |
EUR 327.6 |
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0. |
Anti-Human Serpin A1 Antibody |
101-M627 |
ReliaTech |
100 µg |
EUR 399 |
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins. |
Anti-Human Serpin A3 Antibody |
101-M628 |
ReliaTech |
100 µg |
EUR 399 |
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins. |
Anti-Human Serpin A4 Antibody |
101-M827 |
ReliaTech |
100 µg |
EUR 399 |
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins. |
Anti-Human Serpin E1 Antibody |
101-M828 |
ReliaTech |
100 µg |
EUR 399 |
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins. |
Anti-Human Serpin F1 Antibody |
101-M829 |
ReliaTech |
100 µg |
EUR 399 |
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins. |
Anti-Human Serpin F2 Antibody |
101-M830 |
ReliaTech |
100 µg |
EUR 399 |
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins. |
Anti-Human Serpin I2 Antibody |
101-M831 |
ReliaTech |
100 µg |
EUR 399 |
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins. |
Human Serpin C1/Antithrombin-III PicoKine™ Fast ELISA Kit |
FEK1393 |
BosterBio |
96 wells |
EUR 570 |
Description: The Fast version of Picokine ELISA kits, assay takes less than 1.5 hours. Detect Human Antithrombin Iii/SERPINC1 with <10pg/ml sensitivity. Format: 96-well plate with removable strips. Compatible samples: cell culture supernates, serum, plasma (heparin, EDTA, citrate) and urine. This is a TMB colorimetric sandwich ELISA kit with short assay time and fast experiment set up. Antithrombin Iii/SERPINC1 tissue specificity: Found in plasma. |
Mouse Serpin A1/AAT PicoKine ELISA Kit |
EK1711 |
BosterBio |
96 wells |
EUR 510 |
Description: For quantitative detection of mouse AAT in cell culture supernates, serum and plasma (heparin, EDTA). |
Recombinant Human Serpin C1/Antithrombin III/ATIII Protein, His Tag |
E40KMP1137 |
EnoGene |
20ug |
EUR 495 |
Recombinant Mouse Serpin A1a (C-6His, AH11040.1 ) |
EPT200 |
ELK Biotech |
50ug |
EUR 725.4 |
|
Description: Recombinant Mouse Serine protease inhibitor A1a is produced by our Mammalian expression system and the target gene encoding Glu25-Lys413 is expressed with a 6His tag at the C-terminus. |
Recombinant Human Serpin G1/Plasma protease C1 inhibitor Protein |
RP00197 |
Abclonal |
10 μg |
EUR 136.5 |
|
Mouse Plasma protease C1 inhibitor (Serping1) |
1-CSB-EP021086MO |
Cusabio |
-
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|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Mouse Plasma protease C1 inhibitor(Serping1),partial expressed in E.coli |
Rat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit |
E01A10955 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Goat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit |
E01A45867 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Canine Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit |
E01A63301 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Rabbit Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit |
E01A28435 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Monkey Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit |
E01A72014 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Sheep Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit |
E01A98161 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Bovine Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit |
E01A80731 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Human Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit |
E01A2193 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Key findings: AEBN induced carcinogenesis primarily within the liver by considerably impairing AMPK signaling, inducing oxidative stress, activating Akt/mTOR signaling, growing Ki-67 immunoreactivity and cyclin D1 expression, and considerably diminishing apoptosis. Co-administration of AEBN with vildagliptin (10 mg kg-1 physique weight) for eight weeks lowered liver dysplasia, and considerably decreased free palmitic acid, elevated free oleic acid, normalized lipid profile, decreased oxidative stress, cyclin D1 expression, Ki-67 immunoreactivity, and Bcl2 expression, and elevated the ratio of apoptotic/non-apoptotic cells. Mechanistically, vildagliptin elicited these physiological and molecular alterations by restoring regular AMPK signaling and decreasing the mobile expressions of FASN and HMGCR, restoring AMPK-dependent phosphorylation of p53 at Ser-15 and decreasing Akt/mTOR signaling.