Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP
Intramembrane proteases (IMPs) are a novel class of proteases that catalyze the proteolysis inside the membrane and regulate numerous mobile processes in numerous organisms. RseP, an Escherichia coli site-2 protease (S2P) household IMP, is concerned within the regulation of an extracytoplasmic stress response via the cleavage of membrane-spanning anti-stress-response transcription issue (anti-σE) protein RseA. Extracytoplasmic stresses set off a sequential cleavage of RseA, by which first DegS cleaves off its periplasmic area, and RseP catalyzes the second cleavage of RseA. The 2 tandem-arranged periplasmic PDZ (PDZ tandem) domains of RseP function a size-exclusion filter which prevents the entry of an intact RseA into the energetic website of RseP IMP area. Nevertheless, RseP’s substrate recognition mechanism is just not absolutely understood.
Right here, we discovered {that a} periplasmic area of RseP, situated downstream of the PDZ tandem, comprises a phase (named H1) predicted to kind an amphiphilic helix. Bacterial S2P homologs with numerous numbers of PDZ domains have the same amphiphilic helix within the corresponding area. We demonstrated that the H1 phase types {a partially} membrane-embedded amphiphilic helix on the periplasmic floor of the membrane.
Systematic and random mutagenesis analyses revealed that the H1 helix is necessary for the soundness and proteolytic operate of RseP and that mutations within the H1 phase can have an effect on the PDZ-mediated substrate discrimination. Cross-linking experiments urged that H1 instantly interacts with the DegS-cleaved type of RseA. We suggest that H1 acts as an adaptor required for correct association of the PDZ tandem area to carry out its filter operate and for substrate positioning for its environment friendly cleavage.
Tripeptidyl peptidase I promotes human endometrial epithelial cell adhesive capability implying a job in receptivity
The endometrium undergoes cyclic remodelling all through the menstrual cycle in preparation for embryo implantation which happens in a brief window through the mid-secretory part. It’s throughout this quick ‘receptive window’ that the endometrial luminal epithelium acquires adhesive capability allowing blastocysts agency adhesion to the endometrium to determine being pregnant. Dysregulation in any of those steps can compromise embryo implantation leading to implantation failure and infertility. Many elements contribute to those processes together with and proteases.
Tripeptidyl peptidase 1 is a is a lysosomal serine-type protease nevertheless the contribution of the TPP1 to receptivity is unknown. We aimed to research the function of receptivity in people.Within the present research, TPP1 was expressed in each epithelial and stromal compartments of the endometrium throughout the menstrual cycle. Expression was confined to the cytoplasm of luminal and glandular epithelial cells and stromal cells. Staining of mid-secretory endometrial tissues of ladies with regular fertility and first unexplained infertility confirmed lowered immunostaining depth of TPP1 in luminal epithelial cells of infertile tissues in comparison with fertile tissues.
In contrast, TPP1 ranges in glandular epithelial and stromal cells had been comparable in each teams within the mid-secretory part. Inhibition of TPP1 utilizing siRNA compromised HTR8/SVneo (trophoblast cell line) spheroid adhesion on siRNA-transfected Ishikawa cells (endometrial epithelial cell line) in vitro. This impairment was related to decreased sirtuin 1 (SIRT1), BCL2 and p53 mRNA and unaltered and LIF receptor gene expression between remedy teams. siRNA knockdown of TPP1 in main human endometrial stromal cells didn’t have an effect on decidualization nor the expression of decidualization markers prolactin (PRL) and insulin-like development factor-binding protein 1 (IGFBP1). Taken collectively, our knowledge strongly suggests a job for TPP1 in endometrial receptivity by way of its results on epithelial cell adhesion and suggests lowered ranges related to unexplained infertility might contribute to implantation failure.
Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP
Vildagliptin, a dipeptidyl peptidase-Four inhibitor, reduces betel-nut induced carcinogenesis in feminine mice
Purpose: Betel-nut, a well-liked masticatory amongst Southeast Asian populations is a category I carcinogen, beforehand related to dyslipidemia and aberrant lipid metabolism, and is reported for use extra regularly by females, than males. This research investigates the potential of repurposing the anti-diabetic drug, vildagliptin, a dipeptidyl peptidase-Four inhibitor, for assuaging the oncogenic situation in feminine Swiss Albino mice administered an aqueous extract of betel-nut (AEBN) orally (2 mg ml-1) for 24 weeks.
Primarystrategies: Tissues had been investigated by histopathological, immunohistochemical and apoptosis assays. Biochemical analyses of oxidative stress markers and lipid profile had been carried out utilizing completely different tissues and sera. The expressions of various proteins concerned in lipid metabolism and oncogenic pathways had been evaluated by Western blotting.
) Recombinant Mouse Serpin G1/C1 Inhibitor (C-6His) |
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| CJ07-10ug | Novoprotein | 10ug | EUR 242.4 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl,pH8.0. |
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Recombinant Mouse Serpin G1/C1 Inhibitor (C-6His) |
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| CJ07-1mg | Novoprotein | 1mg | EUR 2983.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl,pH8.0. |
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Recombinant Mouse Serpin G1/C1 Inhibitor (C-6His) |
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| CJ07-500ug | Novoprotein | 500ug | EUR 1935.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl,pH8.0. |
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Recombinant Mouse Serpin G1/C1 Inhibitor (C-6His) |
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| CJ07-50ug | Novoprotein | 50ug | EUR 595.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl,pH8.0. |
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Recombinant Mouse Serpin G1/C1 Inhibitor (C-6His) |
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| AP76070 | SAB | 1mg | EUR 3489 |
 Anti Serpin mouse monoclonal antibody |
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| MBS157795-01mg | MyBiosource | 0.1mg | EUR 350 |
Anti Serpin mouse monoclonal antibody |
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| MBS157795-5x01mg | MyBiosource | 5x0.1mg | EUR 1250 |
) Recombinant Mouse Serpin G1/C1 Inhibitor Protein (C-6His) |
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| MBS2553611-001mg | MyBiosource | 0.01mg | EUR 220 |
Recombinant Mouse Serpin G1/C1 Inhibitor Protein (C-6His) |
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| MBS2553611-005mg | MyBiosource | 0.05mg | EUR 505 |
Recombinant Mouse Serpin G1/C1 Inhibitor Protein (C-6His) |
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| MBS2553611-5x005mg | MyBiosource | 5x0.05mg | EUR 2270 |
 Mouse Monoclonal anti-human Serpin-A1 |
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| hAP-0538 | Angio Proteomie | 100ug | EUR 250 |
 Mouse Monoclonal anti-human Serpin-A3 |
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| hAP-0539 | Angio Proteomie | 100ug | EUR 250 |
 Mouse Monoclonal anti-human Serpin-A4 |
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| hAP-0540 | Angio Proteomie | 100ug | EUR 250 |
 Mouse Monoclonal anti-human Serpin-A5 |
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| hAP-0541 | Angio Proteomie | 100ug | EUR 250 |
 Mouse Monoclonal anti-human Serpin-E1 |
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| hAP-0542 | Angio Proteomie | 100ug | EUR 250 |
 Mouse Monoclonal anti-human Serpin-F1 |
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| hAP-0543 | Angio Proteomie | 100ug | EUR 250 |
 Mouse Monoclonal anti-human Serpin-F2 |
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| hAP-0544 | Angio Proteomie | 100ug | EUR 250 |
 Mouse Monoclonal anti-human Serpin-I2 |
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| hAP-0545 | Angio Proteomie | 100ug | EUR 250 |
) Mouse Serpin H1 (Serpinh1) |
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| 1-CSB-EP021087MO | Cusabio |
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Description: Recombinant Mouse Serpin H1(Serpinh1) expressed in E.coli |
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Mouse Serpin H1 (Serpinh1) |
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| 1-CSB-YP021087MO | Cusabio |
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Description: Recombinant Mouse Serpin H1(Serpinh1) expressed in Yeast |
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，Member1(SERPING1) ELISA Kit) Mouse Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA Kit |
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| E01A19696 | BlueGene | 96T | EUR 700 |
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Description: ELISA |
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Mouse Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA Kit |
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| E03C0353-48wellsplate | BlueGene | 48 wells plate | EUR 280 |
Mouse Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA Kit |
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| E03C0353-96wellsplate | BlueGene | 96 wells plate | EUR 405 |
 Recombinant Serpin C1/Antithrombin-III |
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| MBS201057-0005mg | MyBiosource | 0.005mg | EUR 230 |
Recombinant Serpin C1/Antithrombin-III |
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| MBS201057-002mg | MyBiosource | 0.02mg | EUR 405 |
Recombinant Serpin C1/Antithrombin-III |
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| MBS201057-5x002mg | MyBiosource | 5x0.02mg | EUR 1570 |
 ELISA Kit) Human SERPINC1(Serpin C1) ELISA Kit |
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| EH0560 | FN Test | 96T | EUR 628.92 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375 ng/ml |
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，Member1(SERPING1) ELISA kit) Mouse Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA kit |
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| E03C0353-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA kit |
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| E03C0353-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA kit |
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| E03C0353-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 (AP)) SERPINC1 (SERPINC1, AT3, Antithrombin-III, Serpin C1) (AP) |
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| MBS6257479-01mL | MyBiosource | 0.1mL | EUR 980 |
SERPINC1 (SERPINC1, AT3, Antithrombin-III, Serpin C1) (AP) |
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| MBS6257479-5x01mL | MyBiosource | 5x0.1mL | EUR 4250 |
 (PE)) SERPINC1 (SERPINC1, AT3, Antithrombin-III, Serpin C1) (PE) |
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| MBS6257639-01mL | MyBiosource | 0.1mL | EUR 980 |
SERPINC1 (SERPINC1, AT3, Antithrombin-III, Serpin C1) (PE) |
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| MBS6257639-5x01mL | MyBiosource | 5x0.1mL | EUR 4250 |
 (APC)) SERPINC1 (SERPINC1, AT3, Antithrombin-III, Serpin C1) (APC) |
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| MBS6257511-01mL | MyBiosource | 0.1mL | EUR 980 |
SERPINC1 (SERPINC1, AT3, Antithrombin-III, Serpin C1) (APC) |
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| MBS6257511-5x01mL | MyBiosource | 5x0.1mL | EUR 4250 |
 (HRP)) SERPINC1 (SERPINC1, AT3, Antithrombin-III, Serpin C1) (HRP) |
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| MBS6257607-01mL | MyBiosource | 0.1mL | EUR 980 |
SERPINC1 (SERPINC1, AT3, Antithrombin-III, Serpin C1) (HRP) |
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| MBS6257607-5x01mL | MyBiosource | 5x0.1mL | EUR 4250 |
 (FITC)) SERPINC1 (SERPINC1, AT3, Antithrombin-III, Serpin C1) (FITC) |
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| MBS6257575-01mL | MyBiosource | 0.1mL | EUR 980 |
SERPINC1 (SERPINC1, AT3, Antithrombin-III, Serpin C1) (FITC) |
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| MBS6257575-5x01mL | MyBiosource | 5x0.1mL | EUR 4250 |
 (Biotin)) SERPINC1 (SERPINC1, AT3, Antithrombin-III, Serpin C1) (Biotin) |
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| MBS6257543-01mL | MyBiosource | 0.1mL | EUR 980 |
SERPINC1 (SERPINC1, AT3, Antithrombin-III, Serpin C1) (Biotin) |
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| MBS6257543-5x01mL | MyBiosource | 5x0.1mL | EUR 4250 |
 Protein) Mouse Serpin A9 (SERPINA9) Protein |
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| abx680433-50g | Abbexa | 50 µg | EUR 225 |
 Protein) Mouse Serpin B8 (SerpinB8) Protein |
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| abx691962-100g | Abbexa | 100 µg | EUR 962.5 |
Mouse Serpin B8 (SerpinB8) Protein |
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| abx691962-1mg | Abbexa | 1 mg | Ask for price |
 Protein) Mouse Serpin A12 (SERPINA12) Protein |
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| abx069669-100g | Abbexa | 100 g | EUR 225 |
 Protein) Mouse Serpin B12 (SerpinB12) Protein |
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| abx692093-100g | Abbexa | 100 µg | EUR 962.5 |
Mouse Serpin B12 (SerpinB12) Protein |
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| abx692093-1mg | Abbexa | 1 mg | Ask for price |
 Protein) Mouse Serpin A11 (SerpinA11) Protein |
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| abx692181-100g | Abbexa | 100 µg | EUR 837.5 |
Mouse Serpin A11 (SerpinA11) Protein |
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| abx692181-1mg | Abbexa | 1 mg | Ask for price |
) Recombinant Mouse Serpin H1 (Serpinh1) |
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| CSB-EP021087MO | Cusabio | 2171 mg | Ask for price |
Recombinant Mouse Serpin H1 (Serpinh1) |
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| CSB-EP021087MO-20ug | Cusabio | 20ug | Ask for price |
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Description: 18-417aa |
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) Recombinant Mouse Serpin H1(Serpinh1) |
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| AP70769 | SAB | 1mg | EUR 2826 |
Recombinant Mouse Serpin H1(Serpinh1) |
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| AP72778 | SAB | each | Ask for price |
Recombinant Mouse Serpin H1 (Serpinh1) |
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| CSB-YP021087MO | Cusabio | 5990 mg | Ask for price |
Recombinant Mouse Serpin H1 (Serpinh1) |
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| CSB-YP021087MO-20ug | Cusabio | 20ug | Ask for price |
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Description: 18-417aa |
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) Recombinant Mouse Serpin B8 (Serpinb8) |
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| MBS1217797-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1250 |
Recombinant Mouse Serpin B8 (Serpinb8) |
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| MBS1217797-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 915 |
Recombinant Mouse Serpin B8 (Serpinb8) |
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| MBS1217797-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1040 |
Recombinant Mouse Serpin B8 (Serpinb8) |
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| MBS1217797-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1100 |
Recombinant Mouse Serpin B8 (Serpinb8) |
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| MBS1217797-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1180 |
) Recombinant Mouse Serpin I2 (Serpini2) |
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| MBS1371142-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1260 |
Recombinant Mouse Serpin I2 (Serpini2) |
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| MBS1371142-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 930 |
Recombinant Mouse Serpin I2 (Serpini2) |
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| MBS1371142-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1050 |
Recombinant Mouse Serpin I2 (Serpini2) |
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| MBS1371142-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1120 |
Recombinant Mouse Serpin I2 (Serpini2) |
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| MBS1371142-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1195 |
) Recombinant Mouse Serpin A9 (Serpina9) |
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| MBS1283936-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1265 |
Recombinant Mouse Serpin A9 (Serpina9) |
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| MBS1283936-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 935 |
Recombinant Mouse Serpin A9 (Serpina9) |
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| MBS1283936-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1060 |
Recombinant Mouse Serpin A9 (Serpina9) |
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| MBS1283936-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1125 |
Recombinant Mouse Serpin A9 (Serpina9) |
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| MBS1283936-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1205 |
) SERPINA9, Recombinant, Mouse (Serpin A9) |
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| MBS636893-001mg | MyBiosource | 0.01mg | EUR 800 |
SERPINA9, Recombinant, Mouse (Serpin A9) |
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| MBS636893-5x001mg | MyBiosource | 5x0.01mg | EUR 3455 |
) Recombinant Mouse Serpin B7 (Serpinb7) |
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| MBS1438896-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1255 |
Recombinant Mouse Serpin B7 (Serpinb7) |
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| MBS1438896-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 920 |
Recombinant Mouse Serpin B7 (Serpinb7) |
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| MBS1438896-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1045 |
Recombinant Mouse Serpin B7 (Serpinb7) |
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| MBS1438896-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1105 |
Recombinant Mouse Serpin B7 (Serpinb7) |
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| MBS1438896-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1190 |
) Recombinant Mouse Serpin B6 (Serpinb6) |
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| MBS1485285-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1250 |
Recombinant Mouse Serpin B6 (Serpinb6) |
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| MBS1485285-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 920 |
Recombinant Mouse Serpin B6 (Serpinb6) |
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| MBS1485285-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1045 |
Recombinant Mouse Serpin B6 (Serpinb6) |
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| MBS1485285-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1105 |
Recombinant Mouse Serpin B6 (Serpinb6) |
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| MBS1485285-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1185 |
) Recombinant Mouse Serpin B5 (Serpinb5) |
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| MBS950371-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1250 |
Recombinant Mouse Serpin B5 (Serpinb5) |
|||
| MBS950371-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 915 |
Recombinant Mouse Serpin B5 (Serpinb5) |
|||
| MBS950371-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1040 |
Recombinant Mouse Serpin B5 (Serpinb5) |
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| MBS950371-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1100 |
Recombinant Mouse Serpin B5 (Serpinb5) |
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| MBS950371-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1185 |
) Recombinant Mouse Serpin A12 (Serpina12) |
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| MBS1360055-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1265 |
Recombinant Mouse Serpin A12 (Serpina12) |
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| MBS1360055-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 935 |
Recombinant Mouse Serpin A12 (Serpina12) |
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| MBS1360055-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1060 |
Recombinant Mouse Serpin A12 (Serpina12) |
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| MBS1360055-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1125 |
Recombinant Mouse Serpin A12 (Serpina12) |
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| MBS1360055-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1205 |
) Recombinant Mouse Serpin B11 (Serpinb11) |
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| MBS1383751-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1260 |
Recombinant Mouse Serpin B11 (Serpinb11) |
|||
| MBS1383751-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 930 |
Recombinant Mouse Serpin B11 (Serpinb11) |
|||
| MBS1383751-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1050 |
Recombinant Mouse Serpin B11 (Serpinb11) |
|||
| MBS1383751-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1120 |
Recombinant Mouse Serpin B11 (Serpinb11) |
|||
| MBS1383751-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1195 |
) Recombinant Mouse Serpin B12 (Serpinb12) |
|||
| MBS1362946-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1295 |
Recombinant Mouse Serpin B12 (Serpinb12) |
|||
| MBS1362946-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 975 |
Recombinant Mouse Serpin B12 (Serpinb12) |
|||
| MBS1362946-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1085 |
Recombinant Mouse Serpin B12 (Serpinb12) |
|||
| MBS1362946-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1135 |
Recombinant Mouse Serpin B12 (Serpinb12) |
|||
| MBS1362946-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1235 |
) Recombinant Mouse Serpin A11 (Serpina11) |
|||
| MBS1289125-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1275 |
Recombinant Mouse Serpin A11 (Serpina11) |
|||
| MBS1289125-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 950 |
Recombinant Mouse Serpin A11 (Serpina11) |
|||
| MBS1289125-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1070 |
Recombinant Mouse Serpin A11 (Serpina11) |
|||
| MBS1289125-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1140 |
Recombinant Mouse Serpin A11 (Serpina11) |
|||
| MBS1289125-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1215 |
) Recombinant Mouse Serpin B13 (Serpinb13) |
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| MBS1483734-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1260 |
Recombinant Mouse Serpin B13 (Serpinb13) |
|||
| MBS1483734-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 935 |
Recombinant Mouse Serpin B13 (Serpinb13) |
|||
| MBS1483734-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1055 |
Recombinant Mouse Serpin B13 (Serpinb13) |
|||
| MBS1483734-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1120 |
Recombinant Mouse Serpin B13 (Serpinb13) |
|||
| MBS1483734-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1200 |
) Recombinant Mouse Serpin B10 (Serpinb10) |
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| MBS1479353-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1270 |
Recombinant Mouse Serpin B10 (Serpinb10) |
|||
| MBS1479353-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 940 |
Recombinant Mouse Serpin B10 (Serpinb10) |
|||
| MBS1479353-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1060 |
Recombinant Mouse Serpin B10 (Serpinb10) |
|||
| MBS1479353-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1130 |
Recombinant Mouse Serpin B10 (Serpinb10) |
|||
| MBS1479353-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1210 |
 Recombinant Mouse Serpin H1 |
|||
| MBS717566-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 320 |
Recombinant Mouse Serpin H1 |
|||
| MBS717566-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 320 |
Recombinant Mouse Serpin H1 |
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| MBS717566-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 520 |
Recombinant Mouse Serpin H1 |
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| MBS717566-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 515 |
Recombinant Mouse Serpin H1 |
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| MBS717566-05mgYeast | MyBiosource | 0.5mg(Yeast) | EUR 1260 |
Recombinant Mouse Serpin H1 |
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| MBS9420666-002mg | MyBiosource | 0.02mg | EUR 380 |
Recombinant Mouse Serpin H1 |
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| MBS9420666-01mg | MyBiosource | 0.1mg | EUR 650 |
Recombinant Mouse Serpin H1 |
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| MBS9420666-1mg | MyBiosource | 1mg | EUR 2525 |
Recombinant Mouse Serpin H1 |
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| MBS9420666-5x1mg | MyBiosource | 5x1mg | EUR 11205 |
 ELISA Kit) Mouse Serpin B4 (SERPINB4) ELISA Kit |
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| 20-abx154640 | Abbexa |
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 ELISA Kit) Mouse Serpin A9 (SERPINA9) ELISA Kit |
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| abx546824-96tests | Abbexa | 96 tests | EUR 687.5 |
 ELISA Kit) Mouse Serpin B7 (SERPINB7) ELISA Kit |
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| abx546880-96tests | Abbexa | 96 tests | EUR 687.5 |
 ELISA Kit) Mouse Serpin B8 (SERPINB8) ELISA Kit |
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| abx546883-96tests | Abbexa | 96 tests | EUR 687.5 |
 ELISA Kit) Mouse Serpin I2 (SERPINI2) ELISA Kit |
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| abx546995-96tests | Abbexa | 96 tests | EUR 687.5 |
 ELISA kit) Mouse Serpin H1(SERPINH1) ELISA kit |
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| E01A25401 | BlueGene | 96T | EUR 700 |
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Description: ELISA |
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Mouse Serpin B4 (SERPINB4) ELISA Kit |
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| abx254400-1096tests | Abbexa | 10 × 96 tests | Ask for price |
Mouse Serpin B4 (SERPINB4) ELISA Kit |
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| abx254400-596tests | Abbexa | 5 × 96 tests | Ask for price |
Mouse Serpin B4 (SERPINB4) ELISA Kit |
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| abx254400-96tests | Abbexa | 96 tests | EUR 525 |
 ELISA Kit) Mouse Serpin H1 (SERPINH1) ELISA Kit |
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| AE19982MO-48T | Abebio | 48T | EUR 360 |
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Description: Mouse (Mus musculus) |
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Mouse Serpin H1 (SERPINH1) ELISA Kit |
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| AE19982MO-96T | Abebio | 96T | EUR 610 |
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Description: Mouse (Mus musculus) |
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 ELISA Kit) Mouse Serpin B6 (SERPINB6) ELISA Kit |
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| AE20016MO-48T | Abebio | 48T | EUR 325 |
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Description: Mouse (Mus musculus) |
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Mouse Serpin B6 (SERPINB6) ELISA Kit |
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| AE20016MO-96T | Abebio | 96T | EUR 610 |
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Description: Mouse (Mus musculus) |
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 ELISA Kit) Mouse Serpin B5 (SERPINB5) ELISA Kit |
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| AE20020MO-48T | Abebio | 48T | EUR 325 |
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Description: Mouse (Mus musculus) |
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Mouse Serpin B5 (SERPINB5) ELISA Kit |
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| AE20020MO-96T | Abebio | 96T | EUR 610 |
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Description: Mouse (Mus musculus) |
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Mouse Serpin B6 (SERPINB6) ELISA Kit |
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| abx515610-96tests | Abbexa | 96 tests | EUR 687.5 |
Mouse Serpin B5 (SERPINB5) ELISA Kit |
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| abx515646-96tests | Abbexa | 96 tests | EUR 687.5 |
Mouse Serpin H1(SERPINH1) ELISA kit |
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| E03S0361-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Serpin H1(SERPINH1) ELISA kit |
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| E03S0361-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Serpin H1(SERPINH1) ELISA kit |
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| E03S0361-48wellsplate | BlueGene | 48 wells plate | EUR 280 |
Mouse Serpin H1(SERPINH1) ELISA kit |
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| E03S0361-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Serpin H1(SERPINH1) ELISA kit |
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| E03S0361-96wellsplate | BlueGene | 96 wells plate | EUR 405 |
 Mouse Serpin B8,SERPINB8 ELISA KIT |
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| JOT-EK2462Mo | Jotbody | 96 wells | Ask for price |
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Description: Mouse |
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 Mouse Serpin B5, Serpinb5 ELISA KIT |
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| ELI-03909m | Lifescience Market | 96 Tests | EUR 1038 |
 Elisa kit) Mouse Serpin A9(SERPINA9) Elisa kit |
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| EK731622 | AFG Bioscience LLC | 96 Wells | EUR 0.8 |
 Elisa kit) Mouse Serpin B8(SERPINB8) Elisa kit |
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| EK731629 | AFG Bioscience LLC | 96 Wells | EUR 0.8 |
 Elisa kit) Mouse Serpin B7(SERPINB7) Elisa kit |
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| EK731630 | AFG Bioscience LLC | 96 Wells | EUR 0.8 |
 Elisa kit) Mouse Serpin B6(SERPINB6) Elisa kit |
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| EK731631 | AFG Bioscience LLC | 96 Wells | EUR 0.8 |
 Elisa kit) Mouse Serpin B5(SERPINB5) Elisa kit |
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| EK731632 | AFG Bioscience LLC | 96 Wells | EUR 0.8 |
 Mouse Serpinh1/ Serpin H1 ELISA Kit |
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| E1335Mo | Sunlong | 1 Kit | EUR 543 |
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Description: Cbp1,Hsp47,47 kDa heat shock protein,Collagen-binding protein,Serine protease inhibitor J6,Colligin |
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Mouse Serpin B8,SERPINB8 ELISA KIT |
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| E2462Mo-1096T | Jiaxing Korain Biotech Ltd (BT Labs) | 10*96T | EUR 4122 |
Mouse Serpin B8,SERPINB8 ELISA KIT |
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| E2462Mo-48wells | Jiaxing Korain Biotech Ltd (BT Labs) | 48 wells | EUR 300 |
Mouse Serpin B8,SERPINB8 ELISA KIT |
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| E2462Mo-596T | Jiaxing Korain Biotech Ltd (BT Labs) | 5*96T | EUR 2061 |
Mouse Serpin B8,SERPINB8 ELISA KIT |
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| E2462Mo-96wells | Jiaxing Korain Biotech Ltd (BT Labs) | 96 wells | EUR 458 |
 Mouse Serpin B7, Serpinb7 ELISA KIT |
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| ELI-19120m | Lifescience Market | 96 Tests | EUR 1038 |
 Mouse Serpin A9, Serpina9 ELISA KIT |
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| ELI-29108m | Lifescience Market | 96 Tests | EUR 1038 |
 Mouse Serpin B6, Serpinb6 ELISA KIT |
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| ELI-40953m | Lifescience Market | 96 Tests | EUR 1038 |
 Mouse Serpin B8, Serpinb8 ELISA KIT |
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| ELI-13938m | Lifescience Market | 96 Tests | EUR 1038 |
 Mouse Serpin I2, Serpini2 ELISA KIT |
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| ELI-18265m | Lifescience Market | 96 Tests | EUR 1038 |
 Mouse Serpin B8, SERPINB8 ELISA Kit |
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| MBS1605668-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3955 |
Mouse Serpin B8, SERPINB8 ELISA Kit |
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| MBS1605668-48StripWells | MyBiosource | 48-Strip-Wells | EUR 305 |
Mouse Serpin B8, SERPINB8 ELISA Kit |
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| MBS1605668-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2005 |
Mouse Serpin B8, SERPINB8 ELISA Kit |
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| MBS1605668-96StripWells | MyBiosource | 96-Strip-Wells | EUR 475 |
Mouse Serpin H1 (SERPINH1) ELISA Kit |
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| MBS7250494-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5685 |
Mouse Serpin H1 (SERPINH1) ELISA Kit |
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| MBS7250494-48StripWells | MyBiosource | 48-Strip-Wells | EUR 485 |
Mouse Serpin H1 (SERPINH1) ELISA Kit |
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| MBS7250494-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3020 |
Mouse Serpin H1 (SERPINH1) ELISA Kit |
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| MBS7250494-96StripWells | MyBiosource | 96-Strip-Wells | EUR 690 |
 Mouse Serpin I2, SERPINI2 ELISA Kit |
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| MBS9326772-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Mouse Serpin I2, SERPINI2 ELISA Kit |
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| MBS9326772-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Mouse Serpin I2, SERPINI2 ELISA Kit |
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| MBS9326772-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Mouse Serpin I2, SERPINI2 ELISA Kit |
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| MBS9326772-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Key findings: AEBN induced carcinogenesis primarily within the liver by considerably impairing AMPK signaling, inducing oxidative stress, activating Akt/mTOR signaling, growing Ki-67 immunoreactivity and cyclin D1 expression, and considerably diminishing apoptosis. Co-administration of AEBN with vildagliptin (10 mg kg-1 physique weight) for eight weeks lowered liver dysplasia, and considerably decreased free palmitic acid, elevated free oleic acid, normalized lipid profile, decreased oxidative stress, cyclin D1 expression, Ki-67 immunoreactivity, and Bcl2 expression, and elevated the ratio of apoptotic/non-apoptotic cells. Mechanistically, vildagliptin elicited these physiological and molecular alterations by restoring regular AMPK signaling and decreasing the mobile expressions of FASN and HMGCR, restoring AMPK-dependent phosphorylation of p53 at Ser-15 and decreasing Akt/mTOR signaling.