Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

December 22, 2020 0 By Keith

Intramembrane proteases (IMPs) are a novel class of proteases that catalyze the proteolysis inside the membrane and regulate numerous mobile processes in numerous organisms. RseP, an Escherichia coli site-2 protease (S2P) household IMP, is concerned within the regulation of an extracytoplasmic stress response via the cleavage of membrane-spanning anti-stress-response transcription issue (anti-σE) protein RseA. Extracytoplasmic stresses set off a sequential cleavage of RseA, by which first DegS cleaves off its periplasmic area, and RseP catalyzes the second cleavage of RseA. The 2 tandem-arranged periplasmic PDZ (PDZ tandem) domains of RseP function a size-exclusion filter which prevents the entry of an intact RseA into the energetic website of RseP IMP area. Nevertheless, RseP’s substrate recognition mechanism is just not absolutely understood.

Right here, we discovered {that a} periplasmic area of RseP, situated downstream of the PDZ tandem, comprises a phase (named H1) predicted to kind an amphiphilic helix. Bacterial S2P homologs with numerous numbers of PDZ domains have the same amphiphilic helix within the corresponding area. We demonstrated that the H1 phase types {a partially} membrane-embedded amphiphilic helix on the periplasmic floor of the membrane.

Systematic and random mutagenesis analyses revealed that the H1 helix is necessary for the soundness and proteolytic operate of RseP and that mutations within the H1 phase can have an effect on the PDZ-mediated substrate discrimination. Cross-linking experiments urged that H1 instantly interacts with the DegS-cleaved type of RseA. We suggest that H1 acts as an adaptor required for correct association of the PDZ tandem area to carry out its filter operate and for substrate positioning for its environment friendly cleavage.

 

Tripeptidyl peptidase I promotes human endometrial epithelial cell adhesive capability implying a job in receptivity

The endometrium undergoes cyclic remodelling all through the menstrual cycle in preparation for embryo implantation which happens in a brief window through the mid-secretory part. It’s throughout this quick ‘receptive window’ that the endometrial luminal epithelium acquires adhesive capability allowing blastocysts agency adhesion to the endometrium to determine being pregnant. Dysregulation in any of those steps can compromise embryo implantation leading to implantation failure and infertility. Many elements contribute to those processes together with and proteases.
Tripeptidyl peptidase 1  is a is a lysosomal serine-type protease nevertheless the contribution of the TPP1 to receptivity is unknown. We aimed to research the function of receptivity in people.Within the present research, TPP1 was expressed in each epithelial and stromal compartments of the endometrium throughout the menstrual cycle. Expression was confined to the cytoplasm of luminal and glandular epithelial cells and stromal cells. Staining of mid-secretory endometrial tissues of ladies with regular fertility and first unexplained infertility confirmed lowered immunostaining depth of TPP1 in luminal epithelial cells of infertile tissues in comparison with fertile tissues.
In contrast, TPP1 ranges in glandular epithelial and stromal cells had been comparable in each teams within the mid-secretory part. Inhibition of TPP1 utilizing siRNA compromised HTR8/SVneo (trophoblast cell line) spheroid adhesion on siRNA-transfected Ishikawa cells (endometrial epithelial cell line) in vitro. This impairment was related to decreased sirtuin 1 (SIRT1), BCL2 and p53 mRNA and unaltered and LIF receptor gene expression between remedy teams. siRNA knockdown of TPP1 in main human endometrial stromal cells didn’t have an effect on decidualization nor the expression of decidualization markers prolactin (PRL) and insulin-like development factor-binding protein 1 (IGFBP1). Taken collectively, our knowledge strongly suggests a job for TPP1 in endometrial receptivity by way of its results on epithelial cell adhesion and suggests lowered ranges related to unexplained infertility might contribute to implantation failure.
 Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

Vildagliptin, a dipeptidyl peptidase-Four inhibitor, reduces betel-nut induced carcinogenesis in feminine mice

Purpose: Betel-nut, a well-liked masticatory amongst Southeast Asian populations is a category I carcinogen, beforehand related to dyslipidemia and aberrant lipid metabolism, and is reported for use extra regularly by females, than males. This research investigates the potential of repurposing the anti-diabetic drug, vildagliptin, a dipeptidyl peptidase-Four inhibitor, for assuaging the oncogenic situation in feminine Swiss Albino mice administered an aqueous extract of betel-nut (AEBN) orally (2 mg ml-1) for 24 weeks.
Primarystrategies: Tissues had been investigated by histopathological, immunohistochemical and apoptosis assays. Biochemical analyses of oxidative stress markers and lipid profile had been carried out utilizing completely different tissues and sera. The expressions of various proteins concerned in lipid metabolism and oncogenic pathways had been evaluated by Western blotting.

Recombinant Mouse Serpin G1/C1 Inhibitor (C-6His)

CJ07-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl,pH8.0.

Recombinant Mouse Serpin G1/C1 Inhibitor (C-6His)

CJ07-50ug 50ug
EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl,pH8.0.

Recombinant Mouse Serpin G1/C1 Inhibitor (C-6His)

AP76070 1mg
EUR 3489

Human SERPINC1(Serpin C1) ELISA Kit

EH0560 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375 ng/ml

Mouse Monoclonal anti-human Serpin-A1

hAP-0538 100ug
EUR 250

Mouse Monoclonal anti-human Serpin-A3

hAP-0539 100ug
EUR 250

Mouse Monoclonal anti-human Serpin-A4

hAP-0540 100ug
EUR 250

Mouse Monoclonal anti-human Serpin-A5

hAP-0541 100ug
EUR 250

Mouse Monoclonal anti-human Serpin-E1

hAP-0542 100ug
EUR 250

Mouse Monoclonal anti-human Serpin-F1

hAP-0543 100ug
EUR 250

Mouse Monoclonal anti-human Serpin-F2

hAP-0544 100ug
EUR 250

Mouse Monoclonal anti-human Serpin-I2

hAP-0545 100ug
EUR 250

Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit

E01A19696 96T
EUR 700
Description: ELISA

Mouse Serpin H1 (Serpinh1)

1-CSB-YP021087MO
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
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Description: Recombinant Mouse Serpin H1(Serpinh1) expressed in Yeast

Mouse Serpin H1 (Serpinh1)

1-CSB-EP021087MO
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Description: Recombinant Mouse Serpin H1(Serpinh1) expressed in E.coli

Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E03C0353-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E03C0353-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E03C0353-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Antithrombin-III/Serpin C1 ELISA Kit

E28L0699 96T
EUR 666.67

Mouse Serpin A9 (SERPINA9) Protein

abx680433-50g 50 µg
EUR 225

Mouse Serpin B8 (SerpinB8) Protein

abx691962-100g 100 µg
EUR 962.5

Mouse Serpin B8 (SerpinB8) Protein

abx691962-1mg 1 mg Ask for price

Mouse Serpin A12 (SERPINA12) Protein

abx069669-100g 100 g
EUR 225

Mouse Serpin B12 (SerpinB12) Protein

abx692093-100g 100 µg
EUR 962.5

Mouse Serpin B12 (SerpinB12) Protein

abx692093-1mg 1 mg Ask for price

Mouse Serpin A11 (SerpinA11) Protein

abx692181-100g 100 µg
EUR 837.5

Mouse Serpin A11 (SerpinA11) Protein

abx692181-1mg 1 mg Ask for price

Recombinant Mouse Serpin H1 (Serpinh1)

CSB-YP021087MO 5990 mg Ask for price

Recombinant Mouse Serpin H1 (Serpinh1)

CSB-EP021087MO 2171 mg Ask for price

Recombinant Mouse Serpin H1(Serpinh1)

AP72778 each Ask for price

Recombinant Mouse Serpin H1(Serpinh1)

AP70769 1mg
EUR 2826

Anti-Mouse Serpin E2 Antibody

103-M469 100 µg
EUR 399
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Anti-Mouse Serpin F1 Antibody

103-M470 100 µg
EUR 399
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Anti-Mouse Serpin F2 Antibody

103-M471 100 µg
EUR 399
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Mouse Serpin H1(SERPINH1) ELISA kit

E01A25401 96T
EUR 700
Description: ELISA

Mouse Serpin H1(SERPINH1) ELISA kit

E03S0361-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin H1(SERPINH1) ELISA kit

E03S0361-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin H1(SERPINH1) ELISA kit

E03S0361-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpinh1/ Serpin H1 ELISA Kit

E1335Mo 1 Kit
EUR 543
Description: Cbp1,Hsp47,47 kDa heat shock protein,Collagen-binding protein,Serine protease inhibitor J6,Colligin

Mouse Serpin B6, Serpinb6 ELISA KIT

ELI-40953m 96 Tests
EUR 1038

Mouse Serpin A9(SERPINA9) Elisa kit

EK731622 96 Wells
EUR 0.8

Mouse Serpin B8(SERPINB8) Elisa kit

EK731629 96 Wells
EUR 0.8

Mouse Serpin B7(SERPINB7) Elisa kit

EK731630 96 Wells
EUR 0.8

Mouse Serpin B6(SERPINB6) Elisa kit

EK731631 96 Wells
EUR 0.8

Mouse Serpin B5(SERPINB5) Elisa kit

EK731632 96 Wells
EUR 0.8

Mouse Serpin B5, Serpinb5 ELISA KIT

ELI-03909m 96 Tests
EUR 1038

Mouse Serpin B8, Serpinb8 ELISA KIT

ELI-13938m 96 Tests
EUR 1038

Mouse Serpin A9, Serpina9 ELISA KIT

ELI-29108m 96 Tests
EUR 1038

Mouse Serpin I2, Serpini2 ELISA KIT

ELI-18265m 96 Tests
EUR 1038

Mouse Serpin B7, Serpinb7 ELISA KIT

ELI-19120m 96 Tests
EUR 1038

Mouse Serpin B6 (SERPINB6) ELISA Kit

abx515610-96tests 96 tests
EUR 886.8

Mouse Serpin B5 (SERPINB5) ELISA Kit

abx515646-96tests 96 tests
EUR 801.6

Mouse Serpin B6 (SERPINB6) ELISA Kit

RK13896 96T
EUR 280

Mouse Serpin H1 (SERPINH1) ELISA Kit

RK06502 96T
EUR 280

Mouse Serpin B5 (SERPINB5) ELISA Kit

RK07808 96T
EUR 280

Mouse Serpin B4 (SERPINB4) ELISA Kit

abx254400-1096tests 10 × 96 tests Ask for price

Mouse Serpin B4 (SERPINB4) ELISA Kit

abx254400-596tests 5 × 96 tests Ask for price

Mouse Serpin A9 (SERPINA9) ELISA Kit

abx546824-96tests 96 tests
EUR 687.5

Mouse Serpin B7 (SERPINB7) ELISA Kit

abx546880-96tests 96 tests
EUR 687.5

Mouse Serpin B8 (SERPINB8) ELISA Kit

abx546883-96tests 96 tests
EUR 687.5

Mouse Serpin I2 (SERPINI2) ELISA Kit

abx546995-96tests 96 tests
EUR 687.5

Mouse Serpinb6 / Serpin B6 ELISA Kit

E11772m 96T
EUR 776

Mouse Serpinb5 / Serpin B5 ELISA Kit

E1183m 96T
EUR 776

Mouse Serpinh1 / Serpin H1 ELISA Kit

E0266m 96T
EUR 776

Mouse Serpin A12 (SERPINA12) CLIA Kit

abx196265-100l 100 µl Ask for price

Mouse Serpin A12 (SERPINA12) CLIA Kit

abx196265-50l 50 µl
EUR 618.75

Mouse Serpin B10(SERPINB10) ELISA kit

E01A25400 96T
EUR 700
Description: ELISA

Mouse Serpin B10(SERPINB10) ELISA kit

E03S0360-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Serpin B10(SERPINB10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin B10(SERPINB10) ELISA kit

E03S0360-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Serpin B10(SERPINB10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin B10(SERPINB10) ELISA kit

E03S0360-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Serpin B10(SERPINB10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpina11/ Serpin A11 ELISA Kit

E1326Mo 1 Kit
EUR 543
Description: Gm895

Mouse Serpina12/ Serpin A12 ELISA Kit

E1327Mo 1 Kit
EUR 543
Description: Visceral adipose tissue-derived serine protease inhibitor,Visceral adipose-specific serpin,Vaspin

Mouse Serpinb13/ Serpin B13 ELISA Kit

E1330Mo 1 Kit
EUR 543

Mouse Serpin A11, Serpina11 ELISA KIT

ELI-41407m 96 Tests
EUR 1038

Mouse Serpin B11, Serpinb11 ELISA KIT

ELI-20036m 96 Tests
EUR 1038

Mouse Serpin B13, Serpinb13 ELISA KIT

ELI-20037m 96 Tests
EUR 1038

Mouse Serpin A11(SERPINA11) Elisa kit

EK731616 96 Wells
EUR 0.8

Mouse Serpin B13(SERPINB13) Elisa kit

EK731620 96 Wells
EUR 0.8

Mouse Serpin B12(SERPINB12) Elisa kit

EK731621 96 Wells
EUR 0.8

Mouse Serpin A10 (SERPINA10) ELISA Kit

EKU06955-48T 48T
EUR 571.55

Mouse Serpin A10 (SERPINA10) ELISA Kit

EKU06955-5x96T 5x96T
EUR 3878.38

Mouse Serpin A10 (SERPINA10) ELISA Kit

EKU06955-96T 96T
EUR 816.5

Mouse Serpin A12, Serpina12 ELISA KIT

ELI-02462m 96 Tests
EUR 1038

Mouse Serpin A10 (SERPINA10) ELISA Kit

EKN48066-48T 48T
EUR 389.62

Mouse Serpin A10 (SERPINA10) ELISA Kit

EKN48066-5x96T 5x96T
EUR 2643.85

Mouse Serpin A10 (SERPINA10) ELISA Kit

EKN48066-96T 96T
EUR 556.6

Mouse Serpin B12, Serpinb12 ELISA KIT

ELI-18716m 96 Tests
EUR 1038

Mouse Serpin A12 (SERPINA12) ELISA Kit

abx513785-96tests 96 tests
EUR 801.6

Mouse Serpin B13 (SERPINB13) ELISA Kit

abx517379-96tests 96 tests
EUR 801.6

Mouse Serpin A11 (SERPINA11) ELISA Kit

abx520863-96tests 96 tests
EUR 886.8

Mouse Serpin B10 (SERPINB10) ELISA Kit

abx556075-96tests 96 tests
EUR 801.6

Mouse Serpin B13 (SERPINB13) ELISA Kit

RK13595 96T
EUR 280

Mouse Serpin A11 (SERPINA11) ELISA Kit

RK13652 96T
EUR 280

Mouse Serpin B12 (SERPINB12) ELISA Kit

RK13720 96T
EUR 280

Mouse Serpin A12 (SERPINA12) ELISA Kit

abx254500-1096tests 10 × 96 tests Ask for price

Mouse Serpin A12 (SERPINA12) ELISA Kit

abx254500-596tests 5 × 96 tests Ask for price

Mouse Serpin A12 (SERPINA12) ELISA Kit

abx154840-100g 100 µg
EUR 2950

Mouse Serpin A12 (SERPINA12) ELISA Kit

abx154840-50g 50 µg
EUR 618.75

Mouse Serpin B11 (SERPINB11) ELISA Kit

abx546876-96tests 96 tests
EUR 687.5

Mouse Serpin B12 (SERPINB12) ELISA Kit

abx546878-96tests 96 tests
EUR 687.5

Mouse Serpina12 / Serpin A12 ELISA Kit

E0706m 96T
EUR 776

Mouse Serpinb13 / Serpin B13 ELISA Kit

E15007m 96T
EUR 776

Mouse Serpinb10 / Serpin B10 ELISA Kit

E15046m 96T
EUR 776

Mouse Serpina11 / Serpin A11 ELISA Kit

E8916m 96T
EUR 776

Mouse Serpinb12 / Serpin B12 ELISA Kit

E15575m 96T
EUR 776

Mouse Serpin B8, SERPINB8 GENLISA ELISA

KLM2462 1 x 96 wells
EUR 341

Human Serpin C1/Antithrombin-III PicoKine ELISA Kit

EK1393 96 wells
EUR 510
Description: For quantitative detection of human Serpin C1 in cell culture supernates, serum, plasma (heparin, EDTA, citrate) and urine.

Rat Monoclonal anti-mouse Serpin 5A

mAP-0320 50ug
EUR 400

Rat Monoclonal anti-mouse Serpin E2

mAP-0322 100ug
EUR 250

Rat Monoclonal anti-mouse Serpin F1

mAP-0323 100ug
EUR 250

Rat Monoclonal anti-mouse Serpin F2

mAP-0324 100ug
EUR 250

Rat Monoclonal anti-mouse Serpin A1

mAP-0527 50ug
EUR 400

Rat Monoclonal anti-mouse Serpin A6

mAP-0528 50ug
EUR 400

Active Recombinant Human Serpin C1/Antithrombin-III Protein

RP00140 20 μg
EUR 942.5

Mouse SERPINB10 (Serpin B10) ELISA Kit (CUSTOM)

ELI-30152m 96 Tests
EUR 1038

Sheep Polyclonal anti-mouse Serpin A3N

mAP-5432 50ug
EUR 400

Recombinant Mouse Serpin F1 Protein

RP01582 20μg
EUR 208

Recombinant Human Serpin G1/C1 Inhibitor (C-6His)

AP75237 1mg
EUR 3209

Recombinant Human Serpin G1/C1 Inhibitor (C-6His)

C539-10ug 10ug
EUR 187.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

Recombinant Human Serpin G1/C1 Inhibitor (C-6His)

C539-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

Recombinant Human Serpin G1/C1 Inhibitor (C-6His)

C539-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

Recombinant Human Serpin G1/C1 Inhibitor (C-6His)

C539-50ug 50ug
EUR 442.8
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

Serpina11 ELISA Kit| Mouse Serpin A11 ELISA Kit

EF016180 96 Tests
EUR 826.8

Serpinb10 ELISA Kit| Mouse Serpin B10 ELISA Kit

EF016181 96 Tests
EUR 826.8

Mouse Serpin D1 PicoKine ELISA Kit

EK1969 96 wells
EUR 510
Description: For quantitative detection of mouse Serpin D1 in cell culture supernates, serum and plasma (EDTA, citrate) and urine.

Mouse Maspin(serpin B5) ELISA kit

E01A23238 96T
EUR 700
Description: ELISA

Mouse Maspin(serpin B5) ELISA kit

E03M0026-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Maspin(serpin B5) ELISA kit

E03M0026-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Maspin(serpin B5) ELISA kit

E03M0026-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Recombinant Mouse Serpin E2 (C-10His)

CU57-10ug 10ug
EUR 157.2
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0.

Recombinant Mouse Serpin E2 (C-10His)

CU57-1mg 1mg
EUR 2008.8
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0.

Recombinant Mouse Serpin E2 (C-10His)

CU57-500ug 500ug
EUR 1399.2
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0.

Recombinant Mouse Serpin E2 (C-10His)

CU57-50ug 50ug
EUR 327.6
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0.

Mouse Serpin E1/PAI-1 ELISA KIT

E42EM-048 96T/48T Ask for price

Anti-Human Serpin A1 Antibody

101-M627 100 µg
EUR 399
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Anti-Human Serpin A3 Antibody

101-M628 100 µg
EUR 399
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Anti-Human Serpin A4 Antibody

101-M827 100 µg
EUR 399
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Anti-Human Serpin E1 Antibody

101-M828 100 µg
EUR 399
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Anti-Human Serpin F1 Antibody

101-M829 100 µg
EUR 399
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Anti-Human Serpin F2 Antibody

101-M830 100 µg
EUR 399
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Anti-Human Serpin I2 Antibody

101-M831 100 µg
EUR 399
Description: The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Nori® Mouse Serpin A3N ELISA Kit

GR117460 96-well
EUR 461

Recombinant Mouse Serpin F1/PEDF Protein

PKSM041232-10ug 10ug
EUR 263
Description: Mouse

Recombinant Mouse Serpin F1/PEDF Protein

PKSM041232-50ug 50ug
EUR 489
Description: Mouse

Human Serpin C1/Antithrombin-III PicoKine™ Fast ELISA Kit

FEK1393 96 wells
EUR 570
Description: The Fast version of Picokine ELISA kits, assay takes less than 1.5 hours. Detect Human Antithrombin Iii/SERPINC1 with <10pg/ml sensitivity. Format: 96-well plate with removable strips. Compatible samples: cell culture supernates, serum, plasma (heparin, EDTA, citrate) and urine. This is a TMB colorimetric sandwich ELISA kit with short assay time and fast experiment set up. Antithrombin Iii/SERPINC1 tissue specificity: Found in plasma.

Mouse Serpin A1/AAT PicoKine ELISA Kit

EK1711 96 wells
EUR 510
Description: For quantitative detection of mouse AAT in cell culture supernates, serum and plasma (heparin, EDTA).

Recombinant Human Serpin C1/Antithrombin III/ATIII Protein, His Tag

E40KMP1137 20ug
EUR 495

Nori® Mouse Serpin F2/A2AP ELISA Kit

GR117244 96-well
EUR 461

Serpin Antibody

abx375028-96tests 96 tests
EUR 225

Recombinant Mouse Serpin A3N Protein (His Tag)

PKSM041279-10ug 10ug
EUR 223
Description: Mouse

Recombinant Mouse Serpin A3N Protein (His Tag)

PKSM041279-50ug 50ug
EUR 593
Description: Mouse

Recombinant Mouse Serpin A1a (C-6His, AH11040.1 )

EPT200 50ug
EUR 725.4
Description: Recombinant Mouse Serine protease inhibitor A1a is produced by our Mammalian expression system and the target gene encoding Glu25-Lys413 is expressed with a 6His tag at the C-terminus.

Recombinant Human Serpin G1/Plasma protease C1 inhibitor Protein

RP00197 10 μg
EUR 136.5

Mouse Plasma protease C1 inhibitor (Serping1)

1-CSB-EP021086MO
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Plasma protease C1 inhibitor(Serping1),partial expressed in E.coli

Rat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit

E01A10955 96T
EUR 700
Description: ELISA

Goat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit

E01A45867 96T
EUR 700
Description: ELISA

Nori® Mouse Serpin E1/PAI-1 ELISA Kit

GR117033 96-well
EUR 461

Nori® Mouse Serpin A4/Kallistatin ELISA Kit

GR117263 96-well
EUR 461

Canine Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit

E01A63301 96T
EUR 700
Description: ELISA

Rabbit Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit

E01A28435 96T
EUR 700
Description: ELISA

Monkey Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit

E01A72014 96T
EUR 700
Description: ELISA

Sheep Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit

E01A98161 96T
EUR 700
Description: ELISA

Bovine Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit

E01A80731 96T
EUR 700
Description: ELISA

Human Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA Kit

E01A2193 96T
EUR 700
Description: ELISA

Serpin H1 (SERPINH1) Antibody

20-abx321407
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  • 100 ul
  • 50 ul

Serpin B5 (SERPINB5) Antibody

20-abx321461
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  • 100 ul
  • 50 ul

Serpin B9 (SERPINB9) Antibody

20-abx321527
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  • 100 ul
  • 50 ul

Serpin B5 (SERPINB5) Antibody

20-abx321596
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  • 100 ul
  • 50 ul

Serpin B6 (SERPINB6) Antibody

20-abx322087
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  • 100 ul
  • 50 ul

Serpin B6 (SERPINB6) Antibody

20-abx322088
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  • 100 ul
  • 50 ul

Serpin B3 (SERPINB3) Antibody

20-abx323774
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  • 100 ug
  • 50 ug

Serpin B6 (SERPINB6) Antibody

abx433266-200ul 200 ul
EUR 460.8

Serpin B9 (SERPINB9) Antibody

abx431610-200ul 200 ul
EUR 460.8

Serpin B9 (SERPINB9) Antibody

abx414334-01mg 0.1 mg
EUR 526.8

Serpin B9 (SERPINB9) Antibody

20-abx328658
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  • 100 ug
  • 50 ug

Serpin D1 (SERPIND1) Antibody

20-abx320675
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  • 100 ul
  • 50 ul
Key findings: AEBN induced carcinogenesis primarily within the liver by considerably impairing AMPK signaling, inducing oxidative stress, activating Akt/mTOR signaling, growing Ki-67 immunoreactivity and cyclin D1 expression, and considerably diminishing apoptosis. Co-administration of AEBN with vildagliptin (10 mg kg-1 physique weight) for eight weeks lowered liver dysplasia, and considerably decreased free palmitic acid, elevated free oleic acid, normalized lipid profile, decreased oxidative stress, cyclin D1 expression, Ki-67 immunoreactivity, and Bcl2 expression, and elevated the ratio of apoptotic/non-apoptotic cells. Mechanistically, vildagliptin elicited these physiological and molecular alterations by restoring regular AMPK signaling and decreasing the mobile expressions of FASN and HMGCR, restoring AMPK-dependent phosphorylation of p53 at Ser-15 and decreasing Akt/mTOR signaling.