Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

December 22, 2020 0 By Keith

Intramembrane proteases (IMPs) are a novel class of proteases that catalyze the proteolysis inside the membrane and regulate numerous mobile processes in numerous organisms. RseP, an Escherichia coli site-2 protease (S2P) household IMP, is concerned within the regulation of an extracytoplasmic stress response via the cleavage of membrane-spanning anti-stress-response transcription issue (anti-σE) protein RseA. Extracytoplasmic stresses set off a sequential cleavage of RseA, by which first DegS cleaves off its periplasmic area, and RseP catalyzes the second cleavage of RseA. The 2 tandem-arranged periplasmic PDZ (PDZ tandem) domains of RseP function a size-exclusion filter which prevents the entry of an intact RseA into the energetic website of RseP IMP area. Nevertheless, RseP’s substrate recognition mechanism is just not absolutely understood.

Right here, we discovered {that a} periplasmic area of RseP, situated downstream of the PDZ tandem, comprises a phase (named H1) predicted to kind an amphiphilic helix. Bacterial S2P homologs with numerous numbers of PDZ domains have the same amphiphilic helix within the corresponding area. We demonstrated that the H1 phase types {a partially} membrane-embedded amphiphilic helix on the periplasmic floor of the membrane.

Systematic and random mutagenesis analyses revealed that the H1 helix is necessary for the soundness and proteolytic operate of RseP and that mutations within the H1 phase can have an effect on the PDZ-mediated substrate discrimination. Cross-linking experiments urged that H1 instantly interacts with the DegS-cleaved type of RseA. We suggest that H1 acts as an adaptor required for correct association of the PDZ tandem area to carry out its filter operate and for substrate positioning for its environment friendly cleavage.

 

Tripeptidyl peptidase I promotes human endometrial epithelial cell adhesive capability implying a job in receptivity

The endometrium undergoes cyclic remodelling all through the menstrual cycle in preparation for embryo implantation which happens in a brief window through the mid-secretory part. It’s throughout this quick ‘receptive window’ that the endometrial luminal epithelium acquires adhesive capability allowing blastocysts agency adhesion to the endometrium to determine being pregnant. Dysregulation in any of those steps can compromise embryo implantation leading to implantation failure and infertility. Many elements contribute to those processes together with and proteases.
Tripeptidyl peptidase 1  is a is a lysosomal serine-type protease nevertheless the contribution of the TPP1 to receptivity is unknown. We aimed to research the function of receptivity in people.Within the present research, TPP1 was expressed in each epithelial and stromal compartments of the endometrium throughout the menstrual cycle. Expression was confined to the cytoplasm of luminal and glandular epithelial cells and stromal cells. Staining of mid-secretory endometrial tissues of ladies with regular fertility and first unexplained infertility confirmed lowered immunostaining depth of TPP1 in luminal epithelial cells of infertile tissues in comparison with fertile tissues.
In contrast, TPP1 ranges in glandular epithelial and stromal cells had been comparable in each teams within the mid-secretory part. Inhibition of TPP1 utilizing siRNA compromised HTR8/SVneo (trophoblast cell line) spheroid adhesion on siRNA-transfected Ishikawa cells (endometrial epithelial cell line) in vitro. This impairment was related to decreased sirtuin 1 (SIRT1), BCL2 and p53 mRNA and unaltered and LIF receptor gene expression between remedy teams. siRNA knockdown of TPP1 in main human endometrial stromal cells didn’t have an effect on decidualization nor the expression of decidualization markers prolactin (PRL) and insulin-like development factor-binding protein 1 (IGFBP1). Taken collectively, our knowledge strongly suggests a job for TPP1 in endometrial receptivity by way of its results on epithelial cell adhesion and suggests lowered ranges related to unexplained infertility might contribute to implantation failure.
 Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

Vildagliptin, a dipeptidyl peptidase-Four inhibitor, reduces betel-nut induced carcinogenesis in feminine mice

Purpose: Betel-nut, a well-liked masticatory amongst Southeast Asian populations is a category I carcinogen, beforehand related to dyslipidemia and aberrant lipid metabolism, and is reported for use extra regularly by females, than males. This research investigates the potential of repurposing the anti-diabetic drug, vildagliptin, a dipeptidyl peptidase-Four inhibitor, for assuaging the oncogenic situation in feminine Swiss Albino mice administered an aqueous extract of betel-nut (AEBN) orally (2 mg ml-1) for 24 weeks.
Primarystrategies: Tissues had been investigated by histopathological, immunohistochemical and apoptosis assays. Biochemical analyses of oxidative stress markers and lipid profile had been carried out utilizing completely different tissues and sera. The expressions of various proteins concerned in lipid metabolism and oncogenic pathways had been evaluated by Western blotting.

Recombinant Mouse Serpin G1/C1 Inhibitor (C-6His)

CJ07-50ug 50ug
EUR 496
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl,pH8.0.

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Recombinant Human Serpin G1/C1 Inhibitor (C-6His)

C539-10ug 10ug
EUR 156
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

Recombinant Human Serpin G1/C1 Inhibitor (C-6His)

C539-1mg 1mg
EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

Recombinant Human Serpin G1/C1 Inhibitor (C-6His)

C539-500ug 500ug
EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

Recombinant Human Serpin G1/C1 Inhibitor (C-6His)

C539-50ug 50ug
EUR 369
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

Recombinant Human Serpin C1/Antithrombin III/ATIII Protein

RP00140 20 μg
EUR 353

Recombinant Human Serpin G1/C1 inhibitor/C1IN Protein

RP00197 10 μg
EUR 140

anti-C1 Inactivator

YF-PA10543 50 ug
EUR 363
Description: Mouse polyclonal to C1 Inactivator

anti-C1 Inactivator

YF-PA10544 100 ug
EUR 403
Description: Rabbit polyclonal to C1 Inactivator

anti-C1 Inactivator

YF-PA23327 50 ul
EUR 334
Description: Mouse polyclonal to C1 Inactivator

anti-plexin C1

YF-PA25496 50 ul
EUR 334
Description: Mouse polyclonal to plexin C1

Anti-Serpin B12 Antibody

A13578 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Serpin B12 Antibody (SERPINB12) detection. Tested with WB in Human.

Anti-Serpin A11 antibody

STJ95622 200 µl
EUR 197
Description: Rabbit polyclonal to Serpin A11.

Anti-Serpin B12 antibody

STJ95623 200 µl
EUR 197
Description: Rabbit polyclonal to Serpin B12.

Human Serpin C1/Antithrombin-III PicoKine™ Fast ELISA Kit

FEK1393 96 wells
EUR 475
Description: The Fast version of Picokine ELISA kits, assay takes less than 1.5 hours. Detect Human Antithrombin Iii/SERPINC1 with <10pg/ml sensitivity. Format: 96-well plate with removable strips. Compatible samples: cell culture supernates, serum, plasma (heparin, EDTA, citrate) and urine. This is a TMB colorimetric sandwich ELISA kit with short assay time and fast experiment set up. Antithrombin Iii/SERPINC1 tissue specificity: Found in plasma.

Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E03C0353-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E03C0353-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E03C0353-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Mouse Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Anti-DNAJB6 (2C11-C1)

YF-MA11237 100 ug
EUR 363
Description: Mouse monoclonal to DNAJB6

Anti-plexin C1 (1A12)

YF-MA17154 100 ug
EUR 363
Description: Mouse monoclonal to plexin C1

Anti-Cytochrome c1 Antibody

A02958 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Cytochrome c1 Antibody (CYC1) detection. Tested with WB in Human, Mouse.

Anti-Cytochrome c1 antibody

STJ92623 200 µl
EUR 197
Description: Rabbit polyclonal to Cytochrome c1.

Mouse Apolipoprotein C1 (APO-C1) CLIA Kit

abx196721-96tests 96 tests
EUR 825

Mouse APO-C1(Apolipoprotein C1) ELISA Kit

EM0844 96T
EUR 476.25
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 37.5 ng/ml

Mouse Serpin H1 (Serpinh1)

1-CSB-YP021087MO
  • EUR 504.00
  • EUR 265.00
  • EUR 1832.00
  • EUR 763.00
  • EUR 1216.00
  • EUR 334.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Serpin H1(Serpinh1) expressed in Yeast

Mouse Serpin H1 (Serpinh1)

1-CSB-EP021087MO
  • EUR 505.00
  • EUR 265.00
  • EUR 1827.00
  • EUR 766.00
  • EUR 1218.00
  • EUR 335.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Serpin H1(Serpinh1) expressed in E.coli

CLIA kit for Mouse APO-C1 (Apolipoprotein C1)

E-CL-M0099 1 plate of 96 wells
EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Mouse APO-C1 (Apolipoprotein C1) in samples from Serum, Plasma, Cell supernatant

Anti-C1 Inactivator (3F4-1D9)

YF-MA10108 100 ug
EUR 363
Description: Mouse monoclonal to C1 Inactivator

Anti-Niemann Pick C1 (4H2)

YF-MA10640 100 ug
EUR 363
Description: Mouse monoclonal to Niemann Pick C1

Anti-Stefin B (M1-C1)

YF-MA12592 100 ug
EUR 363
Description: Mouse monoclonal to Stefin B

Anti-hnRNP C1/C2 Antibody

A02726 100ul
EUR 397
Description: Rabbit Polyclonal hnRNP C1/C2 Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-hnRNP C1/2 antibody

STJ93559 200 µl
EUR 197
Description: Rabbit polyclonal to hnRNP C1/2.

Anti-hnRNP C1/C2 antibody

STJ93560 200 µl
EUR 197
Description: Rabbit polyclonal to hnRNP C1/C2.

Serpin E1

E21-537 10ug
EUR 343

Serpin F1

E21-538 10ug
EUR 343

Serpin A3

MO15082 500 ug
EUR 513

Human Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E01C0353-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Human Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E01C0353-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Human Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E01C0353-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Human Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E04C0353-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Rabbit Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E04C0353-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Rabbit Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E04C0353-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Rabbit Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E02C0353-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Rat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E02C0353-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Rat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E02C0353-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Rat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E07C0353-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Porcine Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E07C0353-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Porcine Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E07C0353-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Porcine Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E08C0353-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Canine Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E08C0353-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Canine Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E08C0353-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Canine Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E06C0353-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Goat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E06C0353-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Goat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E06C0353-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Goat Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E09C0353-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Monkey Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E09C0353-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Monkey Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E09C0353-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Monkey Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

APO-C1 ELISA Kit| Mouse Apolipoprotein C1 ELISA Kit

EF013446 96 Tests
EUR 689

Anti-Calicheamicin monoclonal antibody (clone c1)

ADC-AD-011 50 μg
EUR 2940
Description: A mouse monoclonal antibody (clone c1) which specifically againsts the payload Calicheamicin. This product is for research purposes only, not for use in diagnostics.

Anti-Niemann Pick C1/NPC1 Antibody

A00428-2 100ug/vial
EUR 294

Guinea pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E05C0353-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Guinea pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E05C0353-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Guinea pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) ELISA kit

E05C0353-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Guinea pig Serpin Peptidase Inhibitor,Clade G (C1 Inhibitor),Member1(SERPING1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Anti-Ovalbumin IgE Monoclonal Antibody, Clone E-C1

7091 1 mg/ml x 0.1 ml
EUR 338.55
Description: Mouse Anti-Ovalbumin IgE Monoclonal Antibody

Sinocrassoside C1

TBW01629 5mg Ask for price

Ciwujianoside C1

TBZ0180 unit Ask for price

Proanthocyanidin C1

TBZ2552 10mg Ask for price

Combretastatin C1

TBZ1182 unit Ask for price

SKPin C1

2343-25
EUR 419

SKPin C1

2343-5
EUR 142

Gad c1

LF-P0522 0.1 mg
EUR 350
Description: Gad c1 protein

Gad c1

LF-P0522A 0.5 mg
EUR 1247
Description: Gad c1 protein

Gad c1

LF-P0522B 1 mg
EUR 1998
Description: Gad c1 protein

pDsRed1- C1

PVT10761 2 ug
EUR 301

pmScarlet- C1

PVT10762 2 ug
EUR 301

pHcRed1- C1

PVT10767 2 ug
EUR 266

pmCitrine- C1

PVT10776 2 ug
EUR 301

pmVenus- C1

PVT10777 2 ug
EUR 301

pEBFP2-C1

PVT14110 2 ug
EUR 703

pTurboRFP-C1

PVT14117 2 ug
EUR 703

pEYFP-C1

PVT14506 2 ug
EUR 703

Procyanidin C1

HY-N2342 10mg
EUR 681

Bafilomycin C1

B042-1MG 1 mg
EUR 224

Bafilomycin C1

B042-5MG 5 mg
EUR 708

Bafilomycin C1

GA5404-1MG 1 mg
EUR 229

Bafilomycin C1

C4729-1 1 mg
EUR 242

Bafilomycin C1

C4729-5 5 mg
EUR 921

Mouse Plexin C1 ELISA kit

E03P1025-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Plexin C1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Plexin C1 ELISA kit

E03P1025-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Plexin C1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Plexin C1 ELISA kit

E03P1025-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Plexin C1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Apolipoprotein C1 ELISA kit

E03A0514-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Mouse Apolipoprotein C1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Apolipoprotein C1 ELISA kit

E03A0514-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Mouse Apolipoprotein C1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Apolipoprotein C1 ELISA kit

E03A0514-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Mouse Apolipoprotein C1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Apolipoprotein C1 (APOC1) Protein

20-abx065418
  • EUR 648.00
  • EUR 272.00
  • EUR 1943.00
  • EUR 759.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Serpin A1 antibody

70R-50204 100 ul
EUR 244
Description: Purified Polyclonal Serpin A1 antibody

Serpin B5 antibody

70R-50205 100 ul
EUR 244
Description: Purified Polyclonal Serpin B5 antibody

Serpin B9 antibody

70R-50206 100 ul
EUR 244
Description: Purified Polyclonal Serpin B9 antibody

Serpin B4 antibody

70R-50366 100 ul
EUR 244
Description: Purified Polyclonal Serpin B4 antibody

Serpin B7 antibody

70R-50630 100 ul
EUR 244
Description: Purified Polyclonal Serpin B7 antibody

Serpin B5 antibody

70R-33858 100 ug
EUR 327
Description: Rabbit polyclonal Serpin B5 antibody

Serpin A5 Antibody

ABD4300 100 ug
EUR 438

Serpin A6 antibody

70R-12181 100 ug
EUR 403
Description: Rabbit polyclonal Serpin A6 antibody

Serpin A6 Antibody

3906-100
EUR 316

Serpin A6 Antibody

3906-30T
EUR 146

Serpin A5 Antibody

DF4300 200ul
EUR 304
Description: Serpin A5 Antibody detects endogenous levels of total Serpin A5.

Serpin A5 Antibody

34908-100ul 100ul
EUR 252

Serpin A5 Antibody

34908-50ul 50ul
EUR 187

Serpin B5 Antibody

34298-100ul 100ul
EUR 252

Serpin B5 Antibody

34298-50ul 50ul
EUR 187

Serpin B12 Antibody

47983-100ul 100ul
EUR 252

Mouse Serpin B8, Serpinb8 ELISA KIT

ELI-13938m 96 Tests
EUR 865

Mouse Serpin I2, Serpini2 ELISA KIT

ELI-18265m 96 Tests
EUR 865

Mouse Serpin B12, Serpinb12 ELISA KIT

ELI-18716m 96 Tests
EUR 865

Mouse Serpin B7, Serpinb7 ELISA KIT

ELI-19120m 96 Tests
EUR 865

Mouse Serpin B11, Serpinb11 ELISA KIT

ELI-20036m 96 Tests
EUR 865

Mouse Serpin B13, Serpinb13 ELISA KIT

ELI-20037m 96 Tests
EUR 865

Mouse Serpin A9, Serpina9 ELISA KIT

ELI-29108m 96 Tests
EUR 865

Mouse Serpin A12, Serpina12 ELISA KIT

ELI-02462m 96 Tests
EUR 865

Mouse Serpin B5, Serpinb5 ELISA KIT

ELI-03909m 96 Tests
EUR 865

Mouse Maspin(serpin B5) ELISA kit

E03M0026-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Maspin(serpin B5) ELISA kit

E03M0026-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Maspin(serpin B5) ELISA kit

E03M0026-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin B10(SERPINB10) ELISA kit

E03S0360-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Serpin B10(SERPINB10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin B10(SERPINB10) ELISA kit

E03S0360-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Serpin B10(SERPINB10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin B10(SERPINB10) ELISA kit

E03S0360-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Serpin B10(SERPINB10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin H1(SERPINH1) ELISA kit

E03S0361-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin H1(SERPINH1) ELISA kit

E03S0361-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Serpin H1(SERPINH1) ELISA kit

E03S0361-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Recombinant Mouse Serpin E2 (C-10His)

CU57-10ug 10ug
EUR 131
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0.

Recombinant Mouse Serpin E2 (C-10His)

CU57-1mg 1mg
EUR 1674
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0.

Recombinant Mouse Serpin E2 (C-10His)

CU57-500ug 500ug
EUR 1166
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0.

Recombinant Mouse Serpin E2 (C-10His)

CU57-50ug 50ug
EUR 273
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150 mM NaCl,pH8.0.

Mouse Serpin B6, Serpinb6 ELISA KIT

ELI-40953m 96 Tests
EUR 865

Mouse Serpin A11, Serpina11 ELISA KIT

ELI-41407m 96 Tests
EUR 865

Mouse Serpin A11 (SERPINA11) ELISA Kit

abx520863-96tests 96 tests
EUR 739

Mouse Serpin B10 (SERPINB10) ELISA Kit

abx556075-96tests 96 tests
EUR 668

Mouse Serpin A12 (SERPINA12) ELISA Kit

abx513785-96tests 96 tests
EUR 668

Mouse Serpin B6 (SERPINB6) ELISA Kit

abx515610-96tests 96 tests
EUR 739

Mouse Serpin B5 (SERPINB5) ELISA Kit

abx515646-96tests 96 tests
EUR 668

Mouse Serpin B13 (SERPINB13) ELISA Kit

abx517379-96tests 96 tests
EUR 668

Mouse Serpina11/ Serpin A11 ELISA Kit

E1326Mo 1 Kit
EUR 632

Mouse Serpina12/ Serpin A12 ELISA Kit

E1327Mo 1 Kit
EUR 571

Mouse Serpinb13/ Serpin B13 ELISA Kit

E1330Mo 1 Kit
EUR 632

Mouse Serpinh1/ Serpin H1 ELISA Kit

E1335Mo 1 Kit
EUR 571

ELISA kit for Mouse Serpin H1

EK1572 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Serpin H1 in samples from serum, plasma, tissue homogenates and other biological fluids.

Human Anti-Mouse IgG (HAMA) positive control (for use with #200-205-HAM)

200-208-C1 1 ml
EUR 225

Anti-hnRNP C1/C2 Rabbit Monoclonal Antibody

M02726 100ug/vial
EUR 397
Description: Rabbit Monoclonal hnRNP C1/C2 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

Anti-Phospho-hnRNP C1/2 (S260) antibody

STJ90910 200 µl
EUR 197
Description: Rabbit polyclonal to Phospho-hnRNP C1/2 (S260).

Mouse Serum albumin control (level 1 ~ 1ug/ml) for ELISA

6300-C1 1 ml
EUR 141

Mouse Monofunctional C1- tetrahydrofolate synthase, mitochondria

ELI-24946m 96 Tests
EUR 865

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

SEA252Mu-10x96wellstestplate 10x96-wells test plate
EUR 4391.16
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Apolipoprotein C1 (APOC1) in serum, plasma and other biological fluids.

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

SEA252Mu-1x48wellstestplate 1x48-wells test plate
EUR 449.27
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Apolipoprotein C1 (APOC1) in serum, plasma and other biological fluids.

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

SEA252Mu-1x96wellstestplate 1x96-wells test plate
EUR 598.96
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Apolipoprotein C1 (APOC1) in serum, plasma and other biological fluids.

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

SEA252Mu-5x96wellstestplate 5x96-wells test plate
EUR 2395.32
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Apolipoprotein C1 (APOC1) in serum, plasma and other biological fluids.

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

4-SEA252Mu
  • EUR 4442.00
  • EUR 2346.00
  • EUR 599.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Apolipoprotein C1 (APOC1) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Plasma protease C1 inhibitor (Serping1)

1-CSB-EP021086MO
  • EUR 505.00
  • EUR 265.00
  • EUR 1827.00
  • EUR 766.00
  • EUR 1218.00
  • EUR 335.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Plasma protease C1 inhibitor(Serping1),partial expressed in E.coli

Apolipoprotein C1 (APOC1) Polyclonal Antibody (Mouse)

4-PAA252Mu01
  • EUR 236.00
  • EUR 2338.00
  • EUR 586.00
  • EUR 294.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Apolipoprotein C1 (APOC1)

Mouse Plexin- C1, Plxnc1 ELISA KIT

ELI-37319m 96 Tests
EUR 865

pmCherry-C1-EGFP-LC3B(Mouse) Plasmid

PVTB50026-2b 2 ug
EUR 356

Apolipoprotein C1 (APOC1) Monoclonal Antibody (Mouse)

4-MAA252Mu21
  • EUR 253.00
  • EUR 2615.00
  • EUR 649.00
  • EUR 319.00
  • EUR 216.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rat monoclonal antibody against Mouse Apolipoprotein C1 (APOC1)

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

20-abx153662
  • EUR 6642.00
  • EUR 3542.00
  • EUR 825.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

abx575875-96tests 96 tests
EUR 668

Mouse Apolipoprotein C1 (APOC1) CLIA Kit

20-abx491288
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

abx255189-96tests 96 tests
EUR 668

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

DLR-APOC1-Mu-48T 48T
EUR 489
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Apolipoprotein C1 (APOC1) in samples from serum, plasma or other biological fluids.

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

DLR-APOC1-Mu-96T 96T
EUR 635
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Apolipoprotein C1 (APOC1) in samples from serum, plasma or other biological fluids.

Mouse Apolipoprotein C1 ELISA Kit (APOC1)

RK02610 96 Tests
EUR 521

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

RD-APOC1-Mu-48Tests 48 Tests
EUR 489

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

RD-APOC1-Mu-96Tests 96 Tests
EUR 677

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

RDR-APOC1-Mu-48Tests 48 Tests
EUR 511

Mouse Apolipoprotein C1 (APOC1) ELISA Kit

RDR-APOC1-Mu-96Tests 96 Tests
EUR 709

Mouse Apolipoprotein C1(APOC1)ELISA kit

QY-E20149 96T
EUR 361
Key findings: AEBN induced carcinogenesis primarily within the liver by considerably impairing AMPK signaling, inducing oxidative stress, activating Akt/mTOR signaling, growing Ki-67 immunoreactivity and cyclin D1 expression, and considerably diminishing apoptosis. Co-administration of AEBN with vildagliptin (10 mg kg-1 physique weight) for eight weeks lowered liver dysplasia, and considerably decreased free palmitic acid, elevated free oleic acid, normalized lipid profile, decreased oxidative stress, cyclin D1 expression, Ki-67 immunoreactivity, and Bcl2 expression, and elevated the ratio of apoptotic/non-apoptotic cells. Mechanistically, vildagliptin elicited these physiological and molecular alterations by restoring regular AMPK signaling and decreasing the mobile expressions of FASN and HMGCR, restoring AMPK-dependent phosphorylation of p53 at Ser-15 and decreasing Akt/mTOR signaling.