Kinetic characterization of a novel cysteine peptidase from the protozoan Babesia bovis, a potential target for drug design
C1A cysteine peptidases have been proven to play an vital position throughout apicomplexan invasion and egress of host crimson blood cells (RBCs) and due to this fact have been exploited as targets for drug improvement, through which peptidase specificity is deterministic. Babesia bovis genome is presently obtainable and from the 17 putative cysteine peptidases annotated 4 belong to the C1A subfamily. On this examine, we describe the biochemical characterization of a C1A cysteine peptidase, named right here BbCp (B. bovis cysteine peptidase) and consider its potential participation within the parasite asexual cycle in host RBCs.
The recombinant protein was obtained in bacterial inclusion our bodies and after a refolding course of, offered typical kinetic options of the cysteine peptidase household, enhanced exercise within the presence of a decreasing agent, optimum pH between 6.5 and seven.zero and was inhibited by cystatins from R. microplus. Furthermore, rBbCp substrate specificity analysis utilizing a peptide phage show library confirmed a choice for Val > Leu > Phe. Lastly, antibodies anti-rBbCp have been in a position to intervene with B. bovis development in vitro, which highlights the BbCp as a possible goal for drug design. Sign peptides assist newly synthesized proteins attain the cell membrane or be secreted.
As a part of a organic course of key to immune response and surveillance in people, and related to illnesses, e.g. Alzheimer, remnant sign peptides and different transmembrane segments are proteolyzed by the intramembrane aspartyl protease (IAP) enzyme household. Right here, we recognized IAP orthologs all through the tree of life. Along with eukaryotes, IAPs are encoded in metabolically various archaea from a variety of environments. We discovered three distinct clades of archaeal IAPs: (1) Euryarchaeota (e.g. halophilic Halobacteriales, methanogenic Methanosarcinales and Methanomicrobiales, marine Poseidoniales, acidophilic Thermoplasmatales, hyperthermophilic Archaeoglobus spp.), (2) DPANN, and Bathyarchaeota, Crenarchaeota, and Asgard.
Antagonistic occasion profiles of dipeptidyl peptidase-Four inhibitors: knowledge mining of the general public model of the FDA hostile occasion reporting system
Structural Modeling of Cell Wall Peptidase CwpFM (EntFM) Reveals Distinct Intrinsically Disordered Extensions Particular to Pathogenic Bacillus cereus Strains
Serpin B5 Antibody |
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E38PA1886 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
Serpin B5 antibody |
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70R-33858 | Fitzgerald | 100 ug | EUR 294 |
Description: Rabbit polyclonal Serpin B5 antibody |
Serpin B5 antibody |
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70R-50205 | Fitzgerald | 100 ul | EUR 242 |
Description: Purified Polyclonal Serpin B5 antibody |
Serpin B5 Antibody |
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MBS9404826-005mL | MyBiosource | 0.05mL | EUR 245 |
Serpin B5 Antibody |
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MBS9404826-01mL | MyBiosource | 0.1mL | EUR 305 |
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MBS9209447-01mL | MyBiosource | 0.1mL | EUR 415 |
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MBS9209447-5x01mL | MyBiosource | 5x0.1mL | EUR 1841 |
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MBS8580913-01mL | MyBiosource | 0.1mL | EUR 305 |
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MBS8580913-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 465 |
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MBS8509841-01mg | MyBiosource | 0.1mg | EUR 305 |
Serpin B5 Antibody |
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MBS8509841-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 465 |
Serpin B5 Antibody |
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MBS8509841-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 465 |
Serpin B5 Antibody |
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MBS8509841-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 465 |
Serpin B5 Antibody |
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MBS8509841-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 465 |
Serpin B5 Antibody |
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MBS5314825-01mL | MyBiosource | 0.1mL | EUR 470 |
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Serpin B5 (SERPINB5) Antibody |
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20-abx127043 | Abbexa |
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Serpin B5 (SERPINB5) Antibody |
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20-abx115469 | Abbexa |
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Serpin B5 (SERPINB5) Antibody |
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abx038026-100ug | Abbexa | 100 ug | EUR 469.2 |
Serpin B5 (SERPINB5) Antibody |
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20-abx008867 | Abbexa |
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Serpin B5 (SERPINB5) Antibody |
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20-abx014060 | Abbexa |
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Serpin B5 (SERPINB5) Antibody |
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Serpin B5 (SERPINB5) Antibody |
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Serpin B5 (SERPINB5) Antibody |
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20-abx321596 | Abbexa |
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Serpin B5 (SERPINB5) Antibody |
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abx115469-100l | Abbexa | 100 µl | EUR 612.5 |
Serpin B5 (SERPINB5) Antibody |
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abx128086-100l | Abbexa | 100 µl | EUR 275 |
Serpin B5 (SERPINB5) Antibody |
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abx128086-1ml | Abbexa | 1 ml | EUR 750 |
Serpin B5 (SERPINB5) Antibody |
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abx128086-200l | Abbexa | 200 µl | EUR 337.5 |
Serpin B5 (SERPINB5) Antibody |
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abx173450-1ml | Abbexa | 1 ml | EUR 275 |
Serpin B5 (SERPINB5) Antibody |
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abx038026-100g | Abbexa | 100 µg | Ask for price |
Serpin B5 (SERPINB5) Antibody |
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abx038026-10g | Abbexa | 10 µg | EUR 337.5 |
Serpin B5 (SERPINB5) Antibody |
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abx038026-500g | Abbexa | 500 µg | Ask for price |
Serpin B5 (SERPINB5) Antibody |
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abx026594-400l | Abbexa | 400 µl | EUR 525 |
Serpin B5 (SERPINB5) Antibody |
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abx235022-100g | Abbexa | 100 µg | EUR 350 |
Serpin B5 (SERPINB5) Antibody |
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abx137426-100tests | Abbexa | 100 tests | EUR 225 |
Serpin B5 (SERPINB5) Antibody |
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abx321461-100g | Abbexa | 100 µg | EUR 350 |
Serpin B5 (SERPINB5) Antibody |
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abx321461-50g | Abbexa | 50 µg | EUR 237.5 |
Serpin B5 (SERPINB5) Antibody |
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abx321596-100g | Abbexa | 100 µg | EUR 350 |
Serpin B5 (SERPINB5) Antibody |
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abx321596-50g | Abbexa | 50 µg | EUR 237.5 |
Serpin B5 (SERPINB5) Antibody |
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abx329431-100g | Abbexa | 100 µg | Ask for price |
Serpin B5 (SERPINB5) Antibody |
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abx329431-20g | Abbexa | 20 µg | EUR 187.5 |
Serpin B5 (SERPINB5) Antibody |
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abx329431-50g | Abbexa | 50 µg | EUR 250 |
Serpin B5 (SERPINB5) Antibody |
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abx014060-100l | Abbexa | 100 µl | EUR 43.75 |
Serpin B5 (SERPINB5) Antibody |
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abx001093-100l | Abbexa | 100 µl | EUR 475 |
Serpin B5 (SERPINB5) Antibody |
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abx001093-20l | Abbexa | 20 µl | EUR 200 |
Serpin B5 (SERPINB5) Antibody |
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abx001093-50l | Abbexa | 50 µl | EUR 325 |
Polyclonal Serpin B5 Antibody |
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APR05559G | Leading Biology | 0.1ml | EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Serpin B5 . This antibody is tested and proven to work in the following applications: |
Serpin B5 Conjugated Antibody |
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C34298 | SAB | 100ul | EUR 476.4 |
Serpin B5 Conjugated Antibody |
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MBS9445108-01mLAF350 | MyBiosource | 0.1mL(AF350) | EUR 480 |
Serpin B5 Conjugated Antibody |
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MBS9445108-01mLAF405 | MyBiosource | 0.1mL(AF405) | EUR 480 |
Serpin B5 Conjugated Antibody |
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MBS9445108-01mLAF488 | MyBiosource | 0.1mL(AF488) | EUR 480 |
Serpin B5 Conjugated Antibody |
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MBS9445108-01mLAF555 | MyBiosource | 0.1mL(AF555) | EUR 480 |
Serpin B5 Conjugated Antibody |
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MBS9445108-01mLBiotin | MyBiosource | 0.1mL(Biotin) | EUR 480 |
Human Serpin B5 (SERPINB5) Protein |
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abx167006-100g | Abbexa | 100 µg | EUR 575 |
Human Serpin B5 (SERPINB5) Protein |
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abx167006-10g | Abbexa | 10 µg | EUR 225 |
Human Serpin B5 (SERPINB5) Protein |
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abx167006-50g | Abbexa | 50 µg | EUR 400 |
Recombinant Human Serpin B5 (SERPINB5) |
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MBS955200-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1250 |
Recombinant Human Serpin B5 (SERPINB5) |
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MBS955200-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 915 |
Recombinant Human Serpin B5 (SERPINB5) |
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MBS955200-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1040 |
Recombinant Human Serpin B5 (SERPINB5) |
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MBS955200-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1100 |
Recombinant Human Serpin B5 (SERPINB5) |
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MBS955200-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1185 |
Human Serpin B5 ELISA Kit |
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EK2905 | SAB | 96 tests | EUR 599 |
Human Serpin B5 ELISA Kit |
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MBS9426741-5x96Tests | MyBiosource | 5x96Tests | EUR 2820 |
Human Serpin B5 ELISA Kit |
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MBS9426741-96Tests | MyBiosource | 96Tests | EUR 615 |
Human Serpin B5 ELISA Kit |
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MBS760106-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3900 |
Human Serpin B5 ELISA Kit |
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MBS760106-48StripWells | MyBiosource | 48-Strip-Wells | EUR 340 |
Human Serpin B5 ELISA Kit |
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MBS760106-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2045 |
Human Serpin B5 ELISA Kit |
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MBS760106-96StripWells | MyBiosource | 96-Strip-Wells | EUR 455 |
Human Serpin B5 ELISA Kit |
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MBS2885862-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 4080 |
Human Serpin B5 ELISA Kit |
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MBS2885862-48StripWells | MyBiosource | 48-Strip-Wells | EUR 390 |
Human Serpin B5 ELISA Kit |
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MBS2885862-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2220 |
Human Serpin B5 ELISA Kit |
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MBS2885862-96StripWells | MyBiosource | 96-Strip-Wells | EUR 520 |
Human Serpin B5 (SERPINB5) ELISA Kit |
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abx250620-96tests | Abbexa | 96 tests | EUR 801.6 |
Human SERPINB5(Serpin B5) ELISA Kit |
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EH1350 | FN Test | 96T | EUR 681.12 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.938 ng/ml |
Human SERPINB5(Serpin B5) ELISA Kit |
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EKF60670-48T | Biomatik Corporation | 48T | EUR 396.9 |
Human SERPINB5(Serpin B5) ELISA Kit |
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EKF60670-5x96T | Biomatik Corporation | 5x96T | EUR 2693.25 |
Human SERPINB5(Serpin B5) ELISA Kit |
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EKF60670-96T | Biomatik Corporation | 96T | EUR 567 |
Human Serpin B5(SERPINB5) ELISA kit |
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EKC42627-48T | Biomatik Corporation | 48T | EUR 542.78 |
Human Serpin B5(SERPINB5) ELISA kit |
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EKC42627-5x96T | Biomatik Corporation | 5x96T | EUR 3683.15 |
Human Serpin B5(SERPINB5) ELISA kit |
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EKC42627-96T | Biomatik Corporation | 96T | EUR 775.4 |
Human Serpin B5(SERPINB5) Elisa Kit |
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EK713671 | AFG Bioscience LLC | 96 Wells | EUR 0.38 |
Human SERPINB5/ Serpin B5 ELISA Kit |
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E2258Hu | Sunlong | 1 Kit | EUR 515 |
Description: PI5,Maspin,Peptidase inhibitor 5,PI-5 |
Human Serpin B5 (SERPINB5) ELISA Kit |
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AE20021HU-48Tests | Abebio | 48 Tests | EUR 325 |
Description: Human (Homo sapiens) |
Human Serpin B5 (SERPINB5) ELISA Kit |
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AE20021HU-96Tests | Abebio | 96 Tests | EUR 610 |
Description: Human (Homo sapiens) |
Human Serpin B5(SERPINB5) ELISA kit |
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CSB-EL021073HU-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
Description: Quantitativesandwich ELISA kit for measuring Human Serpin B5 (SERPINB5) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Serpin B5(SERPINB5) ELISA kit |
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1-CSB-EL021073HU | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Serpin B5(SERPINB5) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Human Serpin B5 (SERPINB5) ELISA Kit |
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AE20021HU-48T | Abebio | 48T | EUR 325 |
Description: Human (Homo sapiens) |
Human Serpin B5 (SERPINB5) ELISA Kit |
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AE20021HU-96T | Abebio | 96T | EUR 610 |
Description: Human (Homo sapiens) |
Human Serpin B5, SERPINB5 ELISA KIT |
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ELI-03908h | Nova Lifetech | 96tests | EUR 696 |
Human Serpin B5,SERPINB5 ELISA KIT |
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E6161Hu-1096T | Jiaxing Korain Biotech Ltd (BT Labs) | 10*96T | EUR 4122 |
Human Serpin B5,SERPINB5 ELISA KIT |
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E6161Hu-48wells | Jiaxing Korain Biotech Ltd (BT Labs) | 48 wells | EUR 300 |
Human Serpin B5,SERPINB5 ELISA KIT |
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E6161Hu-596T | Jiaxing Korain Biotech Ltd (BT Labs) | 5*96T | EUR 2061 |
Human Serpin B5,SERPINB5 ELISA KIT |
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E6161Hu-96wells | Jiaxing Korain Biotech Ltd (BT Labs) | 96 wells | EUR 458 |
Human Serpin B5 (SERPINB5) ELISA Kit |
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KTE60698-48T | Abbkine | 48T | EUR 339 |
Description: This Human Serpin B5 (SERPINB5) ELISA Kit employs a two-site sandwich ELISA to quantitate SERPINB5. |
Human Serpin B5 (SERPINB5) ELISA Kit |
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KTE60698-96T | Abbkine | 96T | EUR 589 |
Description: This Human Serpin B5 (SERPINB5) ELISA Kit employs a two-site sandwich ELISA to quantitate SERPINB5. |
Human Serpin B5 (SERPINB5) ELISA Kit |
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KTE60698-96T5 | Abbkine | 96 T×5 | EUR 2629 |
Description: This Human Serpin B5 (SERPINB5) ELISA Kit employs a two-site sandwich ELISA to quantitate SERPINB5. |
Human Serpin B5 (SERPINB5) ELISA Kit |
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KTE60698-96T50 | Abbkine | 96 T×50 | EUR 24569 |
Description: This Human Serpin B5 (SERPINB5) ELISA Kit employs a two-site sandwich ELISA to quantitate SERPINB5. |
Human Serpin B5 (SERPINB5) ELISA Kit |
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RK07807 | Abclonal | 96T | EUR 280 |
Human SERPINB5 / Serpin B5 ELISA Kit |
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E1183h | EIAab | 96T | EUR 736 |
Human Serpin B5, SERPINB5 ELISA Kit |
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MBS911955-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5575 |
Human Serpin B5, SERPINB5 ELISA Kit |
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MBS911955-24StripWellsLIMIT1 | MyBiosource | 24-Strip-Wells(LIMIT1) | EUR 275 |
Human Serpin B5, SERPINB5 ELISA Kit |
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MBS911955-48StripWells | MyBiosource | 48-Strip-Wells | EUR 545 |
Human Serpin B5, SERPINB5 ELISA Kit |
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MBS911955-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2920 |
Human Serpin B5, SERPINB5 ELISA Kit |
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MBS911955-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Human Serpin B5, SERPINB5 ELISA Kit |
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MBS1607014-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3460 |
Human Serpin B5, SERPINB5 ELISA Kit |
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MBS1607014-48StripWells | MyBiosource | 48-Strip-Wells | EUR 285 |
Human Serpin B5, SERPINB5 ELISA Kit |
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MBS1607014-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1750 |
Human Serpin B5, SERPINB5 ELISA Kit |
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MBS1607014-96StripWells | MyBiosource | 96-Strip-Wells | EUR 425 |
Human Serpin B5 (SERPINB5) ELISA Kit |
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MBS9714363-48Tests | MyBiosource | 48Tests | EUR 340 |
Human Serpin B5 (SERPINB5) ELISA Kit |
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MBS9714363-5x96Tests | MyBiosource | 5x96Tests | EUR 1820 |
Human Serpin B5 (SERPINB5) ELISA Kit |
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MBS9714363-96Tests | MyBiosource | 96Tests | EUR 500 |
Rabbit anti-human Serpin B5 polyclonal Antibody(SERPINB5) |
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MBS1496442-005mL | MyBiosource | 0.05mL | EUR 190 |
Rabbit anti-human Serpin B5 polyclonal Antibody(SERPINB5) |
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MBS1496442-01mL | MyBiosource | 0.1mL | EUR 270 |
Rabbit anti-human Serpin B5 polyclonal Antibody(SERPINB5) |
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MBS1496442-5x01mL | MyBiosource | 5x0.1mL | EUR 1205 |
Rabbit anti-human Serpin B5 polyclonal Antibody(SERPINB5) |
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MBS968785-005mL | MyBiosource | 0.05mL | EUR 190 |
Rabbit anti-human Serpin B5 polyclonal Antibody(SERPINB5) |
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MBS968785-01mL | MyBiosource | 0.1mL | EUR 270 |
Rabbit anti-human Serpin B5 polyclonal Antibody(SERPINB5) |
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MBS968785-5x01mL | MyBiosource | 5x0.1mL | EUR 1205 |
Human Serpin B5, SERPINB5 GENLISA ELISA |
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KBH6161 | Krishgen | 1 x 96 wells | EUR 286 |
Recombinant Human Serpin B5/SERPINB5/Maspin |
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AP75826 | SAB | 1mg | EUR 3209 |
Recombinant Human Serpin B5/SERPINB5/Maspin |
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CF94-10ug | Novoprotein | 10ug | EUR 175.2 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Recombinant Human Serpin B5/SERPINB5/Maspin |
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CF94-1mg | Novoprotein | 1mg | EUR 2739.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Recombinant Human Serpin B5/SERPINB5/Maspin |
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CF94-500ug | Novoprotein | 500ug | EUR 1935.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Recombinant Human Serpin B5/SERPINB5/Maspin |
|||
CF94-50ug | Novoprotein | 50ug | EUR 363.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Recombinant Human Serpin B5 (SERPINB5) Protein |
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MBS286496-01mg | MyBiosource | 0.1mg | EUR 440 |
Recombinant Human Serpin B5 (SERPINB5) Protein |
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MBS286496-05mg | MyBiosource | 0.5mg | EUR 1200 |
Recombinant Human Serpin B5 (SERPINB5) Protein |
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MBS286496-1mg | MyBiosource | 1mg | EUR 1665 |
Recombinant Human Serpin B5 (SERPINB5) Protein |
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MBS286496-5x1mg | MyBiosource | 5x1mg | EUR 7480 |
Serpin B5 |
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AP87696 | SAB | 1mg | EUR 2640 |
Serpin B5 |
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AP88169 | SAB | 1mg | EUR 2640 |
Serpin B5 |
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AP78851 | SAB | 1mg | EUR 2640 |
Human Serpin B3 Antibody |
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32720-05111 | AssayPro | 150 ug | EUR 215 |
Human Serpin B8 Antibody |
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32735-05111 | AssayPro | 150 ug | EUR 215 |
Human Serpin D1 Antibody |
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32810-05111 | AssayPro | 150 ug | EUR 215 |
ELISA kit for Human Serpin B5 (SERPINB5) |
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KTE60698-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 2538 |
Description: Quantitative sandwich ELISA for measuring Human Serpin B5 (SERPINB5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
Human Maspin(serpin B5) ELISA kit |
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E01A5746 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Human Maspin(serpin B5) ELISA kit |
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E01M0026-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Human Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Maspin(serpin B5) ELISA kit |
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E01M0026-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Human Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Maspin(serpin B5) ELISA kit |
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E01M0026-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Human Maspin(serpin B5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Maspin (serpin B5) ELISA Kit |
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MBS722088-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5685 |
Human Maspin (serpin B5) ELISA Kit |
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MBS722088-48StripWells | MyBiosource | 48-Strip-Wells | EUR 485 |
Human Maspin (serpin B5) ELISA Kit |
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MBS722088-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3020 |
Human Maspin (serpin B5) ELISA Kit |
|||
MBS722088-96StripWells | MyBiosource | 96-Strip-Wells | EUR 690 |
Serpin B5/Maspin |
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MBS201217-005mL | MyBiosource | 0.05mL | EUR 275 |
Serpin B5/Maspin |
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MBS201217-01mL | MyBiosource | 0.1mL | EUR 360 |
Serpin B5/Maspin |
|||
MBS201217-5x01mL | MyBiosource | 5x0.1mL | EUR 1375 |
Human Serpin B3 Antibody (Biotin Conjugate) |
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32720-05121 | AssayPro | 150 ug | EUR 315 |
Human Serpin B8 Antibody (Biotin Conjugate) |
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32735-05121 | AssayPro | 150 ug | EUR 315 |
Human Serpin D1 Antibody (Biotin Conjugate) |
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32810-05121 | AssayPro | 150 ug | EUR 315 |
Human Vaspin (Serpin A12) Antibody |
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30064-05111 | AssayPro | 150 ug | EUR 215 |