Top Monoclonal serpine1 antibody

Osteogenesis imperfecta (OI) is a hereditary illness inflicting lowered bone mass, elevated fracture charge, lengthy bone deformities and vertebral compressions.

Plasminogen Activator Inhibitor 1 (SERPINE1) Antibody

Extra non skeletal findings are attributable to impaired collagen perform and embrace hyperlaxity of joints and blue sclera. Most OI circumstances are attributable to dominant mutations in COL1A1/2 affecting bone formation. Over the last years, recessive types of OI have been recognized, largely affecting posttranslational modification of collagen.

In 2011, mutations in SERPINF1 have been recognized because the molecular explanation for OI sort VI, and thereby a novel pathophysiology of the illness was elucidated. The subgroup of sufferers with OI sort VI are affected by an elevated bone resorption, resulting in the identical signs as noticed in sufferers with an impaired bone formation. Severely affected youngsters are presently handled with intravenous bisphosphonates whatever the underlying mutation and pathophysiology. Sufferers with OI sort VI are identified to have a poor response to such a bisphosphonate remedy.

Deciphering the genetic explanation for OI sort VI in our four sufferers (three youngsters and one adolescent) led to a direct translational strategy within the type of a remedy with the monoclonal RANKL antibody Denosumab (1 mg/kg physique weight each 12 weeks).

0,1ML THIN WALL TUBES eight PER STRIP. WHITE & REAL TIME STRIP CAPS

Quick-term biochemical response to this remedy was reported beforehand. We now current the outcomes after 2 years of remedy and reveal a long run profit in addition to a rise of bone mineral density, a normalization of vertebral form, a rise of mobility, and a lowered fracture charge.

AGT 2 (C4072T) SNP-Screen RT-PCR test for detection of Angiotensinogen mutation 2 (Met235Thr, rs699)ready to use 12 x 8 strip format
T01119-96-S	Sacace Biotechnologies	96	EUR 741.2

AGT 1 (C521T) SNP-Screen RT-PCR test for detection of Angiotensinogen mutation 1 (Thr207Met, rs4762)ready to use 12 x 8 strip format
T01118-96-S	Sacace Biotechnologies	96	EUR 741.2

MTHFR (C677T) SNP-Screen-RT-PCR test for detection of MTHFR gene mutation (Ala222Val; rs1801133)-ready to use 12 x 8 strip format
T01103-96-S	Sacace Biotechnologies	96	EUR 741.2

LPL (Ser447Ter) SNP-Screen RT PCR test for detection of lipoprotein lipase gene mutation (1421C>G, rs328)ready to use 12 x 8 strip format
T01149-96-S	Sacace Biotechnologies	96	EUR 741.2

ADRB2 (C5318G) SNP-Screen RT-PCR test for detection adrenoceptor beta 2, surface gene (Gln27Glu, rs1042714)ready to use 12 x 8 strip format
T01358-96-S	Sacace Biotechnologies	96	EUR 741.2

GPIBA1b (C482T) SNP-Screen RT-PCR test for detection of platelet glycoprotein Ibα gene mutation (Thr145 Met;rs6065)ready to use 12 x 8 strip format
T01179-96-S	Sacace Biotechnologies	96	EUR 741.2

AGT 2 (C4072T) SNP-Screen RT-PCR test for detection of Angiotensinogen mutation 2 (Met235Thr, rs699)ready to use 0,2 ml tube format
T01119-50-T	Sacace Biotechnologies	60	EUR 538.46

FTO (A23525T) SNP-Screen RT-PCR test for detection of FTO gene mutation (rs9939609)ready to use 12 x 8 strip format
T01329-96-S	Sacace Biotechnologies	96	EUR 741.2

TNF (G-308A) SNP-Screen RT PCR test for detection of Tumor necrosis factor mutation (rs1800629)ready to use 12 x 8 strip format
T01177-96-S	Sacace Biotechnologies	96	EUR 741.2

CYP2C9*2 (C430T) SNP-ScreenRT-PCR test for detection of CYP2C9 gene mutation (Arg144Cys; rs1799853)ready to use 12 x 8 strip format
T01104-96-S	Sacace Biotechnologies	96	EUR 741.2

LIPC (-250 G>A) SNP-Screen RT PCR test for detection of Hepatic lipase gene mutation (rs2070895)ready to use 12 x 8 strip format
T01161-96-S	Sacace Biotechnologies	96	EUR 741.2

IL17A (G-197A) SNP-Screen RT PCR test for detection of Interleukin-17A gene mutation (rs2275913)ready to use 12 x 8 strip format
T01171-96-S	Sacace Biotechnologies	96	EUR 741.2

CYP2C19*2 (G681A) SNP-Screen RT-PCR test for detection of CYP2C19 gene mutation (rs4244285)ready to use 12 x 8 strip format
T01323-96-S	Sacace Biotechnologies	96	EUR 741.2

IL28B (C>T) SNP-Screen RT-PCR test for detection of Interleukin mutation 2 (rs12979860)ready to use 12 x 8 strip format
T01371-96-S	Sacace Biotechnologies	96	EUR 741.2

PON1 (Gln192Arg) SNP-Screen RT PCR test for detection of paraoxonase 1 gene mutation (575A>G, rs662)ready to use 12 x 8 strip format
T01125-96-S	Sacace Biotechnologies	96	EUR 741.2

NOS3 (C786T) SNP-ScreenRT-PCR test for detection of Nitric oxide synthase 3 mutation (rs2070744)ready to use 12 x 8 strip format
T01182-96-S	Sacace Biotechnologies	96	EUR 741.2

FGB (G-455A) SNP-Screen RT-PCR test for detection of fibrinogen beta gene (rs1800790)ready to use 12 x 8 strip format
T01107-96-S	Sacace Biotechnologies	96	EUR 741.2

CYP2C19*3 (G636A) SNP-Screen RT-PCR test for detection of CYP2C19 gene mutation (rs4986893)ready to use 12 x 8 strip format
T01324-96-S	Sacace Biotechnologies	96	EUR 741.2

CYP3A5*3 (G6986A) SNP-Screen RT-PCR test for detection of CYP3A5 gene mutation (rs776746)ready to use 12 x 8 strip format
T01331-96-S	Sacace Biotechnologies	96	EUR 741.2

IL28B (T>G) SNP-Screen RT-PCR test for detection of Interleukin mutation 1 (rs8099917)ready to use 12 x 8 strip format
T01349-96-S	Sacace Biotechnologies	96	EUR 741.2

FV (G1691A) Leiden SNP-Screen-RT-PCR test for detection of Leiden mutation (Arg506Gln; rs6025)-ready to use 12 x 8 strip format
T01101-96-S	Sacace Biotechnologies	90	EUR 741.2

FVII (G1238A) SNP-Screen-RT-PCR test for detection of FVII gene mutation (Arg353Gln; rs6046)-ready to use 12 x 8 strip format
T01105-96-S	Sacace Biotechnologies	96	EUR 741.2

FXII (C -4T) SNP-Screen RT-PCR test for detection of factor XII gene mutation (rs1801020)ready to use 12 x 8 strip format
T01356-96-S	Sacace Biotechnologies	96	EUR 741.2

MTR (A2756G) SNP-Screen-RT-PCR test for detection of methionine synthase gene mutation (rs1805087)-ready to use 12 x 8 strip format
T01143-96-S	Sacace Biotechnologies	96	EUR 741.2

APOE Leu48Pro SNP-Screen RT-PCR test for detection of apolipoprotein E mutation (T3100C, rs769452) ready to use 12 x 8 strip format
T01148-96-S	Sacace Biotechnologies	96	EUR 741.2

MTHFR (A1298C) SNP-Screen-RT-PCR test for detection of MTHFR gene mutation (Glu429Ala; Rs1801131)-ready to use 12 x 8 strip format
T01273-96-S	Sacace Biotechnologies	96	EUR 741.2

AGTR1 (A1166C) SNP-Screen RT-PCR test for detection of angiotensin II receptor, type 1 mutation (rs5186)ready to use 12 x 8 strip format
T01131-96-S	Sacace Biotechnologies	96	EUR 741.2

SLCO1B1 (T37041C) SNP-Screen RT-PCR test for detection of SLCO1B1 gene mutation (Val174Ala; rs4149056)ready to use 12 x 8 strip format
T01303-96-S	Sacace Biotechnologies	96	EUR 741.2

ADRB2 (G46A) SNP-Screen RT-PCR test for detection adrenoceptor beta 2, surface gene (Arg16Gly,rs1042713)ready to use 12 x 8 strip format
T01359-96-S	Sacace Biotechnologies	96	EUR 741.2

CYP2C9*3 (A1075C) SNP-Screen RT-PCR test for detection of CYP2C9 gene mutation (Ile359Leu; rs1057910)ready to use 12 x 8 strip format
T01111-96-S	Sacace Biotechnologies	96	EUR 741.2

ITGA2 (С807T) SNP-Screen RT-PCR test for detection of Integrin alpha2 gene mutation (Phe224Phe;rs1126643)ready to use 12 x 8 strip format
T01155-96-S	Sacace Biotechnologies	96	EUR 741.2

FII Protrombin (G20210A) SNP-Screen-RT-PCR test for detection of prothrombin F2 gene mutation (rs1799963)-ready to use 12 x 8 strip format
T01102-96-S	Sacace Biotechnologies	96	EUR 741.2

FXIII (G103T) SNP-Screen RT-PCR test for detection of factor XIII A1 gene mutation (Val35Leu; rs5985)ready to use 12 x 8 strip format
T01355-96-S	Sacace Biotechnologies	96	EUR 741.2

ITGB3 (T176C) SNP-Screen RT-PCR test for detection of Integrin beta-3 gene mutation (Leu33Pro; rs5918)ready to use 12 x 8 strip format
T01106-96-S	Sacace Biotechnologies	96	EUR 741.2

FABP2 (A163G) SNP-Screen RT-PCR test for detection of Fatty Acid Binding Protein 2 gene (Ala54Thr, rs1799883)ready to use 12 x 8 strip format
T01361-96-S	Sacace Biotechnologies	96	EUR 741.2

PAI SERPINE (-675 5G/4G) SNP-Screen PCR test for detection of polymorphism of SERPINE1/PAI1 gene (rs1799768)-ready to use 12 x 8 strip format
T01120-96-S	Sacace Biotechnologies	96	EUR 741.2

ADRB3 (T190C) SNP-Screen RT-PCR test for detection of β-adrenergic receptor genes mutation (Trp64Arg, rs4994)ready to use 12 x 8 strip format
T01360-96-S	Sacace Biotechnologies	96	EUR 741.2

MTRR (A 66 G) SNP-Screen-RT-PCR test for detection of methioninesynthase gene mutation (Ile22Met; rs1801394)-ready to use 12 x 8 strip format
T01124-96-S	Sacace Biotechnologies	96	EUR 741.2

ACE Alu Ins/Del SNP-Screen RT-PCR test for detection of angiotensin II receptor, type 1 mutation (rs5186)ready to use 12 x 8 strip format
T01272-96-S	Sacace Biotechnologies	96	EUR 741.2

AGT 1 (C521T) SNP-Screen RT-PCR test for detection of Angiotensinogen mutation 1 (Thr207Met, rs4762)ready to use 0,2 ml tube format
T01118-50-T	Sacace Biotechnologies	60	EUR 538.46

PPARG2 (C34G) SNP-Screen Real Time PCR test for detection of Peroxisome Proliferator-Activated Receptor-Gamma-2 gene mutation (Pro12Ala, rs1801282)ready to use 12 x 8 strip format
T01335-96-S	Sacace Biotechnologies	96	EUR 741.2

Resistance cephalosporins-1 RT PCR test for Enterobacteriaceae resistance, genes CTX-M ready to use 12 x 8 strip format
T01781-96-T	Sacace Biotechnologies	96	EUR 651.82

GPIBA1b (T -5C ) SNP-Screen RT-PCR test for detection of platelet glycoprotein Ibα gene mutation (Kozak sequence polymorphism; rs2243093)ready to use 12 x 8 strip format
T01354-96-S	Sacace Biotechnologies	96	EUR 741.2

SELPLG (G186A) SNP-ScreenRT-PCR test for detection selectin P ligand gene mutation (Met62Ile; rs2228315)ready to use 12 x 8 strip format
T01357-96-S	Sacace Biotechnologies	96	EUR 741.2

Cardio Trombophilia Panel RT-PCR kit in ready to use 12 x 8 strip format
T01001-96-S	Sacace Biotechnologies	12	EUR 662.72

Folates Methabolism Panel RT-PCR kit in ready to use 12 x 8 strip format
T01002-96-S	Sacace Biotechnologies	24	EUR 662.72

VKORC1 (С1173T) SNP-Screen RT-PCR test for detection Vitamin K epoxide reductase complex subunit 1 gene mutation, Warfarin sensitivity (rs9934438) ready to use 12 x 8 strip format
T01144-96-S	Sacace Biotechnologies	96	EUR 741.2

VKORC1 (G3730A) SNP-Screen RT-PCR test for detection Vitamin K epoxide reductase complex subunit 1 gene mutation, Warfarin resistance (rs7294)ready to use 12 x 8 strip format
T01145-96-S	Sacace Biotechnologies	96	EUR 741.2

MTHFR (C677T) SNP-Screen-RT-PCR test for detection of MTHFR gene mutation (Ala222Val; rs1801133)-ready to use 0,2 ml tube format
T01103-50-T	Sacace Biotechnologies	60	EUR 538.46

Obesity & Diabetes Screen Real Time PCR test for detection of PPARG Pro12Ala,ADRB2 Gln27Glu and Arg16Gly, ADRB3 Trp64Arg, FABP2 Ala54Thr, LPLHindIII, INS -23Hpl, FTO gene mutations - ready to use 12 x 8 strip format
T01372-96-S	Sacace Biotechnologies	12	EUR 970.1

LPL (Ser447Ter) SNP-Screen RT PCR test for detection of lipoprotein lipase gene mutation (1421C>G, rs328)ready to use 0,2 ml tube format
T01149-50-T	Sacace Biotechnologies	60	EUR 538.46

Resistance cephalosporins-3 RT PCR test for Enterobacteriaceae resistance, blaOXA10-ready to use 12 x 8 strip format
T01965-96-T	Sacace Biotechnologies	96	EUR 651.82

ADRB2 (C5318G) SNP-Screen RT-PCR test for detection adrenoceptor beta 2, surface gene (Gln27Glu, rs1042714)ready to use 0,2 ml tube format
T01358-50-T	Sacace Biotechnologies	60	EUR 538.46

GPIBA1b (C482T) SNP-Screen RT-PCR test for detection of platelet glycoprotein Ibα gene mutation (Thr145 Met;rs6065)ready to use 0,2 ml tube format
T01179-50-T	Sacace Biotechnologies	60	EUR 538.46

PeriodontScreen Real-TM RT-PCR kit-ready to use 12 x 8 strip format
T01707-96-S	Sacace Biotechnologies	12	EUR 497.04

Resistance macrolides-2-RT PCR test for Streptococcus spp resistance to macrolides; genes Mef-ready to use 12 x 8 strip format
T01748-96-T	Sacace Biotechnologies	96	EUR 651.82

TNF (G-308A) SNP-Screen RT PCR test for detection of Tumor necrosis factor mutation (rs1800629)ready to use 0,2 ml tube format
T01177-50-T	Sacace Biotechnologies	60	EUR 538.46

LIPC (-250 G>A) SNP-Screen RT PCR test for detection of Hepatic lipase gene mutation (rs2070895)ready to use 0,2 ml tube format
T01161-50-T	Sacace Biotechnologies	60	EUR 538.46

Resistance carbapenems-2 Real Time PCR test for Enterobacteriaceae resistance, genes NDM-ready to use 12 x 8 strip format 96
T01785-96-T	Sacace Biotechnologies	96	EUR 651.82

IL17A (G-197A) SNP-Screen RT PCR test for detection of Interleukin-17A gene mutation (rs2275913)ready to use 0,2 ml tube format
T01171-50-T	Sacace Biotechnologies	60	EUR 538.46

CYP2C9*2 (C430T) SNP-ScreenRT-PCR test for detection of CYP2C9 gene mutation (Arg144Cys; rs1799853)ready to use 0,2 ml tube format
T01104-50-T	Sacace Biotechnologies	60	EUR 538.46

Resistance carbapenems-4 Real Time PCR test for Enterobacteriaceae resistance, genes KPC-ready to use 12 x 8 strip format
T01746-96-T	Sacace Biotechnologies	96	EUR 651.82

FTO (A23525T) SNP-Screen RT-PCR test for detection of FTO gene mutation (rs9939609)ready to use 0,2 ml tube format
T01329-50-T	Sacace Biotechnologies	60	EUR 538.46

PON1 (Gln192Arg) SNP-Screen RT PCR test for detection of paraoxonase 1 gene mutation (575A>G, rs662)ready to use 0,2 ml tube format
T01125-50-T	Sacace Biotechnologies	60	EUR 538.46

CYP2C19*2 (G681A) SNP-Screen RT-PCR test for detection of CYP2C19 gene mutation (rs4244285)ready to use 0,2 ml tube format
T01323-50-T	Sacace Biotechnologies	60	EUR 538.46

IL28B (C>T) SNP-Screen RT-PCR test for detection of Interleukin mutation 2 (rs12979860)ready to use 0,2 ml tube format
T01371-50-T	Sacace Biotechnologies	60	EUR 538.46

NOS3 (C786T) SNP-ScreenRT-PCR test for detection of Nitric oxide synthase 3 mutation (rs2070744)ready to use 0,2 ml tube format
T01182-50-T	Sacace Biotechnologies	60	EUR 538.46

FGB (G-455A) SNP-Screen RT-PCR test for detection of fibrinogen beta gene (rs1800790)ready to use 0,2 ml tube format
T01107-50-T	Sacace Biotechnologies	60	EUR 538.46

IL28B (T>G) SNP-Screen RT-PCR test for detection of Interleukin mutation 1 (rs8099917)ready to use 0,2 ml tube format
T01349-50-T	Sacace Biotechnologies	60	EUR 538.46

Resistance carbapenems-3 Real Time PCR test for Enterobacteriaceae resistance, genes OXA-48-ready to use 12 x 8 strip format
T01786-96-T	Sacace Biotechnologies	96	EUR 651.82

FVII (G1238A) SNP-Screen-RT-PCR test for detection of FVII gene mutation (Arg353Gln; rs6046)-ready to use 0,2 ml tube format
T01105-50-T	Sacace Biotechnologies	60	EUR 538.46

CYP2C19*3 (G636A) SNP-Screen RT-PCR test for detection of CYP2C19 gene mutation (rs4986893)ready to use 0,2 ml tube format
T01324-50-T	Sacace Biotechnologies	60	EUR 538.46

CYP3A5*3 (G6986A) SNP-Screen RT-PCR test for detection of CYP3A5 gene mutation (rs776746)ready to use 0,2 ml tube format
T01331-50-T	Sacace Biotechnologies	60	EUR 538.46

AGTR1 (A1166C) SNP-Screen RT-PCR test for detection of angiotensin II receptor, type 1 mutation (rs5186)ready to use 0,2 ml tube format
T01131-50-T	Sacace Biotechnologies	60	EUR 538.46

FV (G1691A) Leiden SNP-Screen-RT-PCR test for detection of Leiden mutation (Arg506Gln; rs6025)-ready to use 0,2 ml tube format
T01101-50-T	Sacace Biotechnologies	60	EUR 538.46

FXII (C -4T) SNP-Screen RT-PCR test for detection of factor XII gene mutation (rs1801020)ready to use 0,2 ml tube format
T01356-50-T	Sacace Biotechnologies	60	EUR 538.46

ADRB2 (G46A) SNP-Screen RT-PCR test for detection adrenoceptor beta 2, surface gene (Arg16Gly,rs1042713)ready to use 0,2 ml tube format
T01359-50-T	Sacace Biotechnologies	60	EUR 538.46

MTR (A2756G) SNP-Screen-RT-PCR test for detection of methionine synthase gene mutation (rs1805087)-ready to use 0,2 ml tube format
T01143-50-T	Sacace Biotechnologies	60	EUR 538.46

APOE Leu48Pro SNP-Screen RT-PCR test for detection of apolipoprotein E mutation (T3100C, rs769452)ready to use 0,2 ml tube format
T01148-50-T	Sacace Biotechnologies	60	EUR 538.46

MTHFR (A1298C) SNP-Screen-RT-PCR test for detection of MTHFR gene mutation (Glu429Ala; Rs1801131)-ready to use 0,2 ml tube format
T01273-50-T	Sacace Biotechnologies	60	EUR 538.46

SLCO1B1 (T37041C) SNP-Screen RT-PCR test for detection of SLCO1B1 gene mutation (Val174Ala; rs4149056)ready to use 0,2 ml tube format
T01303-50-T	Sacace Biotechnologies	60	EUR 538.46

CYP2C9*3 (A1075C) SNP-Screen RT-PCR test for detection of CYP2C9 gene mutation (Ile359Leu; rs1057910)ready to use 0,2 ml tube format
T01111-50-T	Sacace Biotechnologies	60	EUR 538.46

ITGA2 (С807T) SNP-Screen RT-PCR test for detection of Integrin alpha2 gene mutation (Phe224Phe;rs1126643)ready to use 0,2 ml tube format
T01155-50-T	Sacace Biotechnologies	60	EUR 538.46

FII Protrombin (G20210A) SNP-Screen-RT-PCR test for detection of prothrombin F2 gene mutation (rs1799963)-ready to use 0,2 ml tube format
T01102-50-T	Sacace Biotechnologies	60	EUR 538.46

ITGB3 (T176C) SNP-Screen RT-PCR test for detection of Integrin beta-3 gene mutation (Leu33Pro; rs5918)ready to use 0,2 ml tube format
T01106-50-T	Sacace Biotechnologies	60	EUR 538.46

FXIII (G103T) SNP-Screen RT-PCR test for detection of factor XIII A1 gene mutation (Val35Leu; rs5985)ready to use 0,2 ml tube format
T01355-50-T	Sacace Biotechnologies	60	EUR 538.46

FABP2 (A163G) SNP-Screen RT-PCR test for detection of Fatty Acid Binding Protein 2 gene (Ala54Thr, rs1799883)ready to use 0,2 ml tube format
T01361-50-T	Sacace Biotechnologies	60	EUR 538.46

PAI SERPINE (-675 5G/4G) SNP-Screen PCR test for detection of polymorphism of SERPINE1/PAI1 gene (rs1799768)-ready to use 0,2 ml tube format
T01120-50-T	Sacace Biotechnologies	60	EUR 538.46

Resistance macrolides-1-RT PCR test for for detection of ErmB genes associated with macrolide, lincosamide and streptogramin resistance in Streptococcus spp. and Staphylococcus spp.-ready to use 12 x 8 strip format
T01747-96-T	Sacace Biotechnologies	96	EUR 651.82

MTRR (A 66 G) SNP-Screen-RT-PCR test for detection of methioninesynthase gene mutation (Ile22Met; rs1801394)-ready to use 0,2 ml tube format
T01124-50-T	Sacace Biotechnologies	60	EUR 538.46

ADRB3 (T190C) SNP-Screen RT-PCR test for detection of β-adrenergic receptor genes mutation (Trp64Arg, rs4994)ready to use 0,2 ml tube format
T01360-50-T	Sacace Biotechnologies	60	EUR 538.46

ACE Alu Ins/Del SNP-Screen RT-PCR test for detection of angiotensin II receptor, type 1 mutation (rs5186)ready to use 0,2 ml tube format
T01272-50-T	Sacace Biotechnologies	60	EUR 538.46

PPARG2 (C34G) SNP-Screen Real Time PCR test for detection of Peroxisome Proliferator-Activated Receptor-Gamma-2 gene mutation (Pro12Ala, rs1801282)ready to use 0,2 ml tube format
T01335-50-T	Sacace Biotechnologies	60	EUR 538.46

Resistance carbapenems-5-Real Time PCR test for Enterobacteriaceae resistance to carbapenems, penicillins and cephalosporins, genes blaGES-ready to use 12 x 8 strip format
T01960-96-T	Sacace Biotechnologies	96	EUR 651.82

GPIBA1b (T -5C ) SNP-Screen RT-PCR test for detection of platelet glycoprotein Ibα gene mutation (Kozak sequence polymorphism; rs2243093)ready to use 0,2 ml tube format
T01354-50-T	Sacace Biotechnologies	60	EUR 538.46

This report presents the primary two-year knowledge of denosumab remedy in sufferers with Osteogenesis imperfecta sort VI and in Osteogenesis imperfecta on the whole as an efficient and apparently protected remedy possibility.