Inhibition of SERPINE1/protease nexin-1 by a monoclonal antibody attenuates airway reworking in a murine mannequin of bronchial asthma.
- SERPINE1, often known as protease nexin-1 (PN-1), is a serine protease inhibitor produced by many cell sorts and has pleiotropic organic capabilities. It has been reported that SERPINE1/PN-1 is concerned in tissue reworking of fibrotic ailments together with idiopathic pulmonary fibrosis and cardiac fibrosis.
Monoclonal SERPINE1 Antibody (monoclonal) (M01), Clone: 3F2
- Nevertheless, the potential position of SERPINE1/PN-1 in asthmatic airway reworking has remained barely investigated up to now. On this examine, BALB/c male mice have been sensitized and challenged by ovalbumin to generate murine fashions of airway reworking.
- Anti-SERPINE1monoclonal antibody was intraperitoneally injected into these mice through the ovalbumin problem whereas IgG antibody was used as a car management.
Mouse Monoclonal Antibody to Human Topoisomerase IIIα
- The outcomes revealed that the expression of SERPINE1/PN-1 was considerably upregulated within the lung extracts of ovalbumin-challenged mice, and this upregulation was inhibited by dexamethasone. Sustained ovalbumin stimulation elevated the thickness of airway wall and α-SMA optimistic areas in lung, which was attenuated by the remedy with SERPINE1antibody.
- As well as, SERPINE1antibody partially blocked the phosphorylation of ERK, and lowered the upregulation of MMP-9 and TIMP-1 expressions in asthmatic mice. These findings recommend that SERPINE1/PN-1 could play a job within the pathologic improvement of airway reworking. Monoclonal antibody towards SERPINE1could have the potential as an efficient pharmacotherapy for asthmatic airway reworking.
Two years’ expertise with denosumab for youngsters with osteogenesis imperfecta sort VI.
BACKGROUND
Osteogenesis imperfecta (OI) is a hereditary illness inflicting lowered bone mass, elevated fracture charge, lengthy bone deformities and vertebral compressions.
Plasminogen Activator Inhibitor 1 (SERPINE1) Antibody
Extra non skeletal findings are attributable to impaired collagen perform and embrace hyperlaxity of joints and blue sclera. Most OI circumstances are attributable to dominant mutations in COL1A1/2 affecting bone formation. Over the last years, recessive types of OI have been recognized, largely affecting posttranslational modification of collagen.
In 2011, mutations in SERPINF1 have been recognized because the molecular explanation for OI sort VI, and thereby a novel pathophysiology of the illness was elucidated. The subgroup of sufferers with OI sort VI are affected by an elevated bone resorption, resulting in the identical signs as noticed in sufferers with an impaired bone formation. Severely affected youngsters are presently handled with intravenous bisphosphonates whatever the underlying mutation and pathophysiology. Sufferers with OI sort VI are identified to have a poor response to such a bisphosphonate remedy.
METHODS
Deciphering the genetic explanation for OI sort VI in our four sufferers (three youngsters and one adolescent) led to a direct translational strategy within the type of a remedy with the monoclonal RANKL antibody Denosumab (1 mg/kg physique weight each 12 weeks).
0,1ML THIN WALL TUBES eight PER STRIP. WHITE & REAL TIME STRIP CAPS
RESULTS
Quick-term biochemical response to this remedy was reported beforehand. We now current the outcomes after 2 years of remedy and reveal a long run profit in addition to a rise of bone mineral density, a normalization of vertebral form, a rise of mobility, and a lowered fracture charge.
 SNP-Screen RT-PCR test for detection of Angiotensinogen mutation 2 (Met235Thr, rs699)ready to use 12 x 8 strip format) AGT 2 (C4072T) SNP-Screen RT-PCR test for detection of Angiotensinogen mutation 2 (Met235Thr, rs699)ready to use 12 x 8 strip format |
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T01119-96-S |
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96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection of Angiotensinogen mutation 1 (Thr207Met, rs4762)ready to use 12 x 8 strip format) AGT 1 (C521T) SNP-Screen RT-PCR test for detection of Angiotensinogen mutation 1 (Thr207Met, rs4762)ready to use 12 x 8 strip format |
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T01118-96-S |
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96 |
EUR 741.2 |
 SNP-Screen-RT-PCR test for detection of MTHFR gene mutation (Ala222Val; rs1801133)-ready to use 12 x 8 strip format) MTHFR (C677T) SNP-Screen-RT-PCR test for detection of MTHFR gene mutation (Ala222Val; rs1801133)-ready to use 12 x 8 strip format |
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T01103-96-S |
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96 |
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 SNP-Screen RT PCR test for detection of lipoprotein lipase gene mutation (1421C>G, rs328)ready to use 12 x 8 strip format) LPL (Ser447Ter) SNP-Screen RT PCR test for detection of lipoprotein lipase gene mutation (1421C>G, rs328)ready to use 12 x 8 strip format |
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T01149-96-S |
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96 |
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 SNP-Screen RT-PCR test for detection adrenoceptor beta 2, surface gene (Gln27Glu, rs1042714)ready to use 12 x 8 strip format) ADRB2 (C5318G) SNP-Screen RT-PCR test for detection adrenoceptor beta 2, surface gene (Gln27Glu, rs1042714)ready to use 12 x 8 strip format |
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T01358-96-S |
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96 |
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 SNP-Screen RT-PCR test for detection of platelet glycoprotein Ibα gene mutation (Thr145 Met;rs6065)ready to use 12 x 8 strip format) GPIBA1b (C482T) SNP-Screen RT-PCR test for detection of platelet glycoprotein Ibα gene mutation (Thr145 Met;rs6065)ready to use 12 x 8 strip format |
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T01179-96-S |
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96 |
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 SNP-Screen RT-PCR test for detection of Angiotensinogen mutation 2 (Met235Thr, rs699)ready to use 0,2 ml tube format) AGT 2 (C4072T) SNP-Screen RT-PCR test for detection of Angiotensinogen mutation 2 (Met235Thr, rs699)ready to use 0,2 ml tube format |
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T01119-50-T |
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60 |
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 SNP-Screen RT PCR test for detection of Tumor necrosis factor mutation (rs1800629)ready to use 12 x 8 strip format) TNF (G-308A) SNP-Screen RT PCR test for detection of Tumor necrosis factor mutation (rs1800629)ready to use 12 x 8 strip format |
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T01177-96-S |
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 SNP-ScreenRT-PCR test for detection of CYP2C9 gene mutation (Arg144Cys; rs1799853)ready to use 12 x 8 strip format) CYP2C9*2 (C430T) SNP-ScreenRT-PCR test for detection of CYP2C9 gene mutation (Arg144Cys; rs1799853)ready to use 12 x 8 strip format |
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T01104-96-S |
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96 |
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 SNP-Screen RT PCR test for detection of Hepatic lipase gene mutation (rs2070895)ready to use 12 x 8 strip format) LIPC (-250 G>A) SNP-Screen RT PCR test for detection of Hepatic lipase gene mutation (rs2070895)ready to use 12 x 8 strip format |
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T01161-96-S |
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96 |
EUR 741.2 |
 SNP-Screen RT PCR test for detection of Interleukin-17A gene mutation (rs2275913)ready to use 12 x 8 strip format) IL17A (G-197A) SNP-Screen RT PCR test for detection of Interleukin-17A gene mutation (rs2275913)ready to use 12 x 8 strip format |
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96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection of CYP2C19 gene mutation (rs4244285)ready to use 12 x 8 strip format) CYP2C19*2 (G681A) SNP-Screen RT-PCR test for detection of CYP2C19 gene mutation (rs4244285)ready to use 12 x 8 strip format |
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T01323-96-S |
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96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection of Interleukin mutation 2 (rs12979860)ready to use 12 x 8 strip format) IL28B (C>T) SNP-Screen RT-PCR test for detection of Interleukin mutation 2 (rs12979860)ready to use 12 x 8 strip format |
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T01371-96-S |
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96 |
EUR 741.2 |
 SNP-Screen RT PCR test for detection of paraoxonase 1 gene mutation (575A>G, rs662)ready to use 12 x 8 strip format) PON1 (Gln192Arg) SNP-Screen RT PCR test for detection of paraoxonase 1 gene mutation (575A>G, rs662)ready to use 12 x 8 strip format |
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T01125-96-S |
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96 |
EUR 741.2 |
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T01182-96-S |
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96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection of fibrinogen beta gene (rs1800790)ready to use 12 x 8 strip format) FGB (G-455A) SNP-Screen RT-PCR test for detection of fibrinogen beta gene (rs1800790)ready to use 12 x 8 strip format |
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T01107-96-S |
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96 |
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T01324-96-S |
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96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection of CYP3A5 gene mutation (rs776746)ready to use 12 x 8 strip format) CYP3A5*3 (G6986A) SNP-Screen RT-PCR test for detection of CYP3A5 gene mutation (rs776746)ready to use 12 x 8 strip format |
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T01331-96-S |
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96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection of Interleukin mutation 1 (rs8099917)ready to use 12 x 8 strip format) IL28B (T>G) SNP-Screen RT-PCR test for detection of Interleukin mutation 1 (rs8099917)ready to use 12 x 8 strip format |
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T01349-96-S |
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96 |
EUR 741.2 |
 Leiden SNP-Screen-RT-PCR test for detection of Leiden mutation (Arg506Gln; rs6025)-ready to use 12 x 8 strip format) FV (G1691A) Leiden SNP-Screen-RT-PCR test for detection of Leiden mutation (Arg506Gln; rs6025)-ready to use 12 x 8 strip format |
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T01101-96-S |
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90 |
EUR 741.2 |
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96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection of factor XII gene mutation (rs1801020)ready to use 12 x 8 strip format) FXII (C -4T) SNP-Screen RT-PCR test for detection of factor XII gene mutation (rs1801020)ready to use 12 x 8 strip format |
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T01356-96-S |
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96 |
EUR 741.2 |
 SNP-Screen-RT-PCR test for detection of methionine synthase gene mutation (rs1805087)-ready to use 12 x 8 strip format) MTR (A2756G) SNP-Screen-RT-PCR test for detection of methionine synthase gene mutation (rs1805087)-ready to use 12 x 8 strip format |
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T01143-96-S |
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96 |
EUR 741.2 |
 ready to use 12 x 8 strip format) APOE Leu48Pro SNP-Screen RT-PCR test for detection of apolipoprotein E mutation (T3100C, rs769452) ready to use 12 x 8 strip format |
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T01148-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 SNP-Screen-RT-PCR test for detection of MTHFR gene mutation (Glu429Ala; Rs1801131)-ready to use 12 x 8 strip format) MTHFR (A1298C) SNP-Screen-RT-PCR test for detection of MTHFR gene mutation (Glu429Ala; Rs1801131)-ready to use 12 x 8 strip format |
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T01273-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection of angiotensin II receptor, type 1 mutation (rs5186)ready to use 12 x 8 strip format) AGTR1 (A1166C) SNP-Screen RT-PCR test for detection of angiotensin II receptor, type 1 mutation (rs5186)ready to use 12 x 8 strip format |
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T01131-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection of SLCO1B1 gene mutation (Val174Ala; rs4149056)ready to use 12 x 8 strip format) SLCO1B1 (T37041C) SNP-Screen RT-PCR test for detection of SLCO1B1 gene mutation (Val174Ala; rs4149056)ready to use 12 x 8 strip format |
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T01303-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection adrenoceptor beta 2, surface gene (Arg16Gly,rs1042713)ready to use 12 x 8 strip format) ADRB2 (G46A) SNP-Screen RT-PCR test for detection adrenoceptor beta 2, surface gene (Arg16Gly,rs1042713)ready to use 12 x 8 strip format |
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T01359-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection of CYP2C9 gene mutation (Ile359Leu; rs1057910)ready to use 12 x 8 strip format) CYP2C9*3 (A1075C) SNP-Screen RT-PCR test for detection of CYP2C9 gene mutation (Ile359Leu; rs1057910)ready to use 12 x 8 strip format |
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T01111-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection of Integrin alpha2 gene mutation (Phe224Phe;rs1126643)ready to use 12 x 8 strip format) ITGA2 (С807T) SNP-Screen RT-PCR test for detection of Integrin alpha2 gene mutation (Phe224Phe;rs1126643)ready to use 12 x 8 strip format |
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T01155-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 SNP-Screen-RT-PCR test for detection of prothrombin F2 gene mutation (rs1799963)-ready to use 12 x 8 strip format) FII Protrombin (G20210A) SNP-Screen-RT-PCR test for detection of prothrombin F2 gene mutation (rs1799963)-ready to use 12 x 8 strip format |
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T01102-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection of factor XIII A1 gene mutation (Val35Leu; rs5985)ready to use 12 x 8 strip format) FXIII (G103T) SNP-Screen RT-PCR test for detection of factor XIII A1 gene mutation (Val35Leu; rs5985)ready to use 12 x 8 strip format |
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T01355-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection of Integrin beta-3 gene mutation (Leu33Pro; rs5918)ready to use 12 x 8 strip format) ITGB3 (T176C) SNP-Screen RT-PCR test for detection of Integrin beta-3 gene mutation (Leu33Pro; rs5918)ready to use 12 x 8 strip format |
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T01106-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection of Fatty Acid Binding Protein 2 gene (Ala54Thr, rs1799883)ready to use 12 x 8 strip format) FABP2 (A163G) SNP-Screen RT-PCR test for detection of Fatty Acid Binding Protein 2 gene (Ala54Thr, rs1799883)ready to use 12 x 8 strip format |
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T01361-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 SNP-Screen PCR test for detection of polymorphism of SERPINE1/PAI1 gene (rs1799768)-ready to use 12 x 8 strip format) PAI SERPINE (-675 5G/4G) SNP-Screen PCR test for detection of polymorphism of SERPINE1/PAI1 gene (rs1799768)-ready to use 12 x 8 strip format |
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T01120-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection of β-adrenergic receptor genes mutation (Trp64Arg, rs4994)ready to use 12 x 8 strip format) ADRB3 (T190C) SNP-Screen RT-PCR test for detection of β-adrenergic receptor genes mutation (Trp64Arg, rs4994)ready to use 12 x 8 strip format |
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T01360-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 SNP-Screen-RT-PCR test for detection of methioninesynthase gene mutation (Ile22Met; rs1801394)-ready to use 12 x 8 strip format) MTRR (A 66 G) SNP-Screen-RT-PCR test for detection of methioninesynthase gene mutation (Ile22Met; rs1801394)-ready to use 12 x 8 strip format |
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T01124-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
ready to use 12 x 8 strip format) ACE Alu Ins/Del SNP-Screen RT-PCR test for detection of angiotensin II receptor, type 1 mutation (rs5186)ready to use 12 x 8 strip format |
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T01272-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection of Angiotensinogen mutation 1 (Thr207Met, rs4762)ready to use 0,2 ml tube format) AGT 1 (C521T) SNP-Screen RT-PCR test for detection of Angiotensinogen mutation 1 (Thr207Met, rs4762)ready to use 0,2 ml tube format |
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T01118-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
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T01335-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 Resistance cephalosporins-1 RT PCR test for Enterobacteriaceae resistance, genes CTX-M ready to use 12 x 8 strip format |
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T01781-96-T |
Sacace Biotechnologies |
96 |
EUR 651.82 |
 SNP-Screen RT-PCR test for detection of platelet glycoprotein Ibα gene mutation (Kozak
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sequence polymorphism; rs2243093)ready to use 12 x 8 strip format |
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T01354-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
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T01357-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection Vitamin K epoxide reductase complex subunit 1 gene
mutation, Warfarin sensitivity (rs9934438) ready to use 12 x 8 strip format) VKORC1 (С1173T) SNP-Screen RT-PCR test for detection Vitamin K epoxide reductase complex subunit 1 gene
mutation, Warfarin sensitivity (rs9934438) ready to use 12 x 8 strip format |
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T01144-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 SNP-Screen RT-PCR test for detection Vitamin K epoxide reductase complex subunit 1 gene
mutation, Warfarin resistance (rs7294)ready to use 12 x 8 strip format) VKORC1 (G3730A) SNP-Screen RT-PCR test for detection Vitamin K epoxide reductase complex subunit 1 gene
mutation, Warfarin resistance (rs7294)ready to use 12 x 8 strip format |
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T01145-96-S |
Sacace Biotechnologies |
96 |
EUR 741.2 |
 SNP-Screen-RT-PCR test for detection of MTHFR gene mutation (Ala222Val; rs1801133)-ready to use 0,2 ml tube format) MTHFR (C677T) SNP-Screen-RT-PCR test for detection of MTHFR gene mutation (Ala222Val; rs1801133)-ready to use 0,2 ml tube format |
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T01103-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 Obesity & Diabetes Screen
Real Time PCR test for detection of PPARG Pro12Ala,ADRB2
Gln27Glu and Arg16Gly, ADRB3 Trp64Arg, FABP2 Ala54Thr,
LPLHindIII, INS -23Hpl, FTO gene mutations - ready to use
12 x 8 strip format |
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T01372-96-S |
Sacace Biotechnologies |
12 |
EUR 970.1 |
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T01149-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 Resistance cephalosporins-3 RT PCR test for Enterobacteriaceae resistance, blaOXA10-ready to use 12 x 8 strip format |
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T01965-96-T |
Sacace Biotechnologies |
96 |
EUR 651.82 |
 SNP-Screen RT-PCR test for detection adrenoceptor beta 2, surface gene (Gln27Glu, rs1042714)ready to use 0,2 ml tube format) ADRB2 (C5318G) SNP-Screen RT-PCR test for detection adrenoceptor beta 2, surface gene (Gln27Glu, rs1042714)ready to use 0,2 ml tube format |
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T01358-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT-PCR test for detection of platelet glycoprotein Ibα gene mutation (Thr145 Met;rs6065)ready to use 0,2 ml tube format) GPIBA1b (C482T) SNP-Screen RT-PCR test for detection of platelet glycoprotein Ibα gene mutation (Thr145 Met;rs6065)ready to use 0,2 ml tube format |
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T01179-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 Resistance macrolides-2-RT PCR test for Streptococcus spp resistance to macrolides; genes Mef-ready to use 12 x 8 strip format |
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T01748-96-T |
Sacace Biotechnologies |
96 |
EUR 651.82 |
 SNP-Screen RT PCR test for detection of Tumor necrosis factor mutation (rs1800629)ready to use 0,2 ml tube format) TNF (G-308A) SNP-Screen RT PCR test for detection of Tumor necrosis factor mutation (rs1800629)ready to use 0,2 ml tube format |
|
T01177-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT PCR test for detection of Hepatic lipase gene mutation (rs2070895)ready to use 0,2 ml tube format) LIPC (-250 G>A) SNP-Screen RT PCR test for detection of Hepatic lipase gene mutation (rs2070895)ready to use 0,2 ml tube format |
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T01161-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 Resistance carbapenems-2 Real Time PCR test for Enterobacteriaceae resistance, genes NDM-ready to use 12 x 8 strip format 96 |
|
T01785-96-T |
Sacace Biotechnologies |
96 |
EUR 651.82 |
 SNP-ScreenRT-PCR test for detection of CYP2C9 gene mutation (Arg144Cys; rs1799853)ready to use 0,2 ml tube format) CYP2C9*2 (C430T) SNP-ScreenRT-PCR test for detection of CYP2C9 gene mutation (Arg144Cys; rs1799853)ready to use 0,2 ml tube format |
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T01104-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT PCR test for detection of Interleukin-17A gene mutation (rs2275913)ready to use 0,2 ml tube format) IL17A (G-197A) SNP-Screen RT PCR test for detection of Interleukin-17A gene mutation (rs2275913)ready to use 0,2 ml tube format |
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T01171-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 Resistance carbapenems-4 Real Time PCR test for Enterobacteriaceae resistance, genes KPC-ready to use 12 x 8 strip format |
|
T01746-96-T |
Sacace Biotechnologies |
96 |
EUR 651.82 |
 SNP-Screen RT PCR test for detection of paraoxonase 1 gene mutation (575A>G, rs662)ready to use 0,2 ml tube format) PON1 (Gln192Arg) SNP-Screen RT PCR test for detection of paraoxonase 1 gene mutation (575A>G, rs662)ready to use 0,2 ml tube format |
|
T01125-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT-PCR test for detection of CYP2C19 gene mutation (rs4244285)ready to use 0,2 ml tube format) CYP2C19*2 (G681A) SNP-Screen RT-PCR test for detection of CYP2C19 gene mutation (rs4244285)ready to use 0,2 ml tube format |
|
T01323-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT-PCR test for detection of Interleukin mutation 2 (rs12979860)ready to use 0,2 ml tube format) IL28B (C>T) SNP-Screen RT-PCR test for detection of Interleukin mutation 2 (rs12979860)ready to use 0,2 ml tube format |
|
T01371-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-ScreenRT-PCR test for detection of Nitric oxide synthase 3 mutation (rs2070744)ready to use 0,2 ml tube format) NOS3 (C786T) SNP-ScreenRT-PCR test for detection of Nitric oxide synthase 3 mutation (rs2070744)ready to use 0,2 ml tube format |
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T01182-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT-PCR test for detection of fibrinogen beta gene (rs1800790)ready to use 0,2 ml tube format) FGB (G-455A) SNP-Screen RT-PCR test for detection of fibrinogen beta gene (rs1800790)ready to use 0,2 ml tube format |
|
T01107-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT-PCR test for detection of Interleukin mutation 1 (rs8099917)ready to use 0,2 ml tube format) IL28B (T>G) SNP-Screen RT-PCR test for detection of Interleukin mutation 1 (rs8099917)ready to use 0,2 ml tube format |
|
T01349-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 Resistance carbapenems-3 Real Time PCR test for Enterobacteriaceae resistance, genes OXA-48-ready to use 12 x 8 strip format |
|
T01786-96-T |
Sacace Biotechnologies |
96 |
EUR 651.82 |
 SNP-Screen-RT-PCR test for detection of FVII gene mutation (Arg353Gln; rs6046)-ready to use 0,2 ml tube format) FVII (G1238A) SNP-Screen-RT-PCR test for detection of FVII gene mutation (Arg353Gln; rs6046)-ready to use 0,2 ml tube format |
|
T01105-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT-PCR test for detection of CYP2C19 gene mutation (rs4986893)ready to use 0,2 ml tube format) CYP2C19*3 (G636A) SNP-Screen RT-PCR test for detection of CYP2C19 gene mutation (rs4986893)ready to use 0,2 ml tube format |
|
T01324-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT-PCR test for detection of CYP3A5 gene mutation (rs776746)ready to use 0,2 ml tube format) CYP3A5*3 (G6986A) SNP-Screen RT-PCR test for detection of CYP3A5 gene mutation (rs776746)ready to use 0,2 ml tube format |
|
T01331-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT-PCR test for detection of angiotensin II receptor, type 1 mutation (rs5186)ready to use 0,2 ml tube format) AGTR1 (A1166C) SNP-Screen RT-PCR test for detection of angiotensin II receptor, type 1 mutation (rs5186)ready to use 0,2 ml tube format |
|
T01131-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 Leiden SNP-Screen-RT-PCR test for detection of Leiden mutation (Arg506Gln; rs6025)-ready to use 0,2 ml tube format) FV (G1691A) Leiden SNP-Screen-RT-PCR test for detection of Leiden mutation (Arg506Gln; rs6025)-ready to use 0,2 ml tube format |
|
T01101-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT-PCR test for detection of factor XII gene mutation (rs1801020)ready to use 0,2 ml tube format) FXII (C -4T) SNP-Screen RT-PCR test for detection of factor XII gene mutation (rs1801020)ready to use 0,2 ml tube format |
|
T01356-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT-PCR test for detection adrenoceptor beta 2, surface gene (Arg16Gly,rs1042713)ready to use 0,2 ml tube format) ADRB2 (G46A) SNP-Screen RT-PCR test for detection adrenoceptor beta 2, surface gene (Arg16Gly,rs1042713)ready to use 0,2 ml tube format |
|
T01359-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen-RT-PCR test for detection of methionine synthase gene mutation (rs1805087)-ready to use 0,2 ml tube format) MTR (A2756G) SNP-Screen-RT-PCR test for detection of methionine synthase gene mutation (rs1805087)-ready to use 0,2 ml tube format |
|
T01143-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
ready to use 0,2 ml tube format) APOE Leu48Pro SNP-Screen RT-PCR test for detection of apolipoprotein E mutation (T3100C, rs769452)ready to use 0,2 ml tube format |
|
T01148-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen-RT-PCR test for detection of MTHFR gene mutation (Glu429Ala; Rs1801131)-ready to use 0,2 ml tube format) MTHFR (A1298C) SNP-Screen-RT-PCR test for detection of MTHFR gene mutation (Glu429Ala; Rs1801131)-ready to use 0,2 ml tube format |
|
T01273-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT-PCR test for detection of SLCO1B1 gene mutation (Val174Ala; rs4149056)ready to use 0,2 ml tube format) SLCO1B1 (T37041C) SNP-Screen RT-PCR test for detection of SLCO1B1 gene mutation (Val174Ala; rs4149056)ready to use 0,2 ml tube format |
|
T01303-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT-PCR test for detection of CYP2C9 gene mutation (Ile359Leu; rs1057910)ready to use 0,2 ml tube format) CYP2C9*3 (A1075C) SNP-Screen RT-PCR test for detection of CYP2C9 gene mutation (Ile359Leu; rs1057910)ready to use 0,2 ml tube format |
|
T01111-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT-PCR test for detection of Integrin alpha2 gene mutation (Phe224Phe;rs1126643)ready to use 0,2 ml tube format) ITGA2 (С807T) SNP-Screen RT-PCR test for detection of Integrin alpha2 gene mutation (Phe224Phe;rs1126643)ready to use 0,2 ml tube format |
|
T01155-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen-RT-PCR test for detection of prothrombin F2 gene mutation (rs1799963)-ready to use 0,2 ml tube format) FII Protrombin (G20210A) SNP-Screen-RT-PCR test for detection of prothrombin F2 gene mutation (rs1799963)-ready to use 0,2 ml tube format |
|
T01102-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT-PCR test for detection of Integrin beta-3 gene mutation (Leu33Pro; rs5918)ready to use 0,2 ml tube format) ITGB3 (T176C) SNP-Screen RT-PCR test for detection of Integrin beta-3 gene mutation (Leu33Pro; rs5918)ready to use 0,2 ml tube format |
|
T01106-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT-PCR test for detection of factor XIII A1 gene mutation (Val35Leu; rs5985)ready to use 0,2 ml tube format) FXIII (G103T) SNP-Screen RT-PCR test for detection of factor XIII A1 gene mutation (Val35Leu; rs5985)ready to use 0,2 ml tube format |
|
T01355-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT-PCR test for detection of Fatty Acid Binding Protein 2 gene (Ala54Thr, rs1799883)ready to use 0,2 ml tube format) FABP2 (A163G) SNP-Screen RT-PCR test for detection of Fatty Acid Binding Protein 2 gene (Ala54Thr, rs1799883)ready to use 0,2 ml tube format |
|
T01361-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen PCR test for detection of polymorphism of SERPINE1/PAI1 gene (rs1799768)-ready to use 0,2 ml tube format) PAI SERPINE (-675 5G/4G) SNP-Screen PCR test for detection of polymorphism of SERPINE1/PAI1 gene (rs1799768)-ready to use 0,2 ml tube format |
|
T01120-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 Resistance macrolides-1-RT PCR test for for detection of ErmB genes associated with macrolide, lincosamide and streptogramin resistance in Streptococcus spp. and Staphylococcus spp.-ready to use 12 x 8 strip format |
|
T01747-96-T |
Sacace Biotechnologies |
96 |
EUR 651.82 |
 SNP-Screen-RT-PCR test for detection of methioninesynthase gene mutation (Ile22Met; rs1801394)-ready to use 0,2 ml tube format) MTRR (A 66 G) SNP-Screen-RT-PCR test for detection of methioninesynthase gene mutation (Ile22Met; rs1801394)-ready to use 0,2 ml tube format |
|
T01124-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen RT-PCR test for detection of β-adrenergic receptor genes mutation (Trp64Arg, rs4994)ready to use 0,2 ml tube format) ADRB3 (T190C) SNP-Screen RT-PCR test for detection of β-adrenergic receptor genes mutation (Trp64Arg, rs4994)ready to use 0,2 ml tube format |
|
T01360-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
ready to use 0,2 ml tube format) ACE Alu Ins/Del SNP-Screen RT-PCR test for detection of angiotensin II receptor, type 1 mutation (rs5186)ready to use 0,2 ml tube format |
|
T01272-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 SNP-Screen Real Time PCR test for detection of Peroxisome Proliferator-Activated Receptor-Gamma-2 gene mutation (Pro12Ala, rs1801282)ready to use 0,2 ml tube format) PPARG2 (C34G) SNP-Screen Real Time PCR test for detection of Peroxisome Proliferator-Activated Receptor-Gamma-2 gene mutation (Pro12Ala, rs1801282)ready to use 0,2 ml tube format |
|
T01335-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
 Resistance carbapenems-5-Real Time PCR test for Enterobacteriaceae resistance to carbapenems,
penicillins and cephalosporins, genes blaGES-ready to use 12 x 8 strip format |
|
T01960-96-T |
Sacace Biotechnologies |
96 |
EUR 651.82 |
 SNP-Screen RT-PCR test for detection of platelet glycoprotein Ibα gene mutation (Kozak
sequence polymorphism; rs2243093)ready to use 0,2 ml tube format) GPIBA1b (T -5C ) SNP-Screen RT-PCR test for detection of platelet glycoprotein Ibα gene mutation (Kozak
sequence polymorphism; rs2243093)ready to use 0,2 ml tube format |
|
T01354-50-T |
Sacace Biotechnologies |
60 |
EUR 538.46 |
CONCLUSIONS
This report presents the primary two-year knowledge of denosumab remedy in sufferers with Osteogenesis imperfecta sort VI and in Osteogenesis imperfecta on the whole as an efficient and apparently protected remedy possibility.
