Dipeptidyl peptidase Four inhibitors (DPP4i) have been out there for treating kind 2 diabetes mellitus since 2006. Though they’re a various group, DPP4i are all small, orally out there molecules that work together with the catalytic website of DPP4 with out disturbing any of its different identified features, together with its results on the immune system. DPP4i don’t have any intrinsic glucose-lowering exercise, so their efficacy as anti-diabetic brokers is said on to their capability to inhibit DPP4 exercise and is mediated by way of the consequences of the substrates they defend. Of those, the incretin hormone, glucagon-like peptide 1, might be crucial. As the consequences of glucagon-like peptide 1 are glucose-dependent, the chance of hypoglycaemia with DPP4i is low.
Class results, that are instantly associated to the mechanism of motion, are frequent to all DPP4i; these embrace their total good security profile and tolerability, in addition to their efficacy in enhancing glycaemic management, but additionally, doubtlessly, a small elevated danger of acute pancreatitis. Compound-specific results are these associated to their differing chemistries and/or pharmacokinetic profiles. These compound-specific results may have an effect on the best way through which particular person DPP4i are used therapeutically and doubtlessly clarify off-target antagonistic results, comparable to hospitalization for coronary heart failure, which is seen solely with one DPP4i. General, DPP4i have a beneficial therapeutic profile and are protected and efficient within the majority of sufferers with kind 2 diabetes mellitus. Households through which the proteins share related tertiary buildings are assembled right into a clan.
The MEROPS classification is thus a hierarchy with at the very least three ranges (protein-species, household and clan) displaying the evolutionary relationship. A number of different knowledge collections have been assembled that are accessed from all ranges within the hierarchy. These embrace, sequence homologues, selective bibliographies, substrate cleavage websites, peptidase-inhibitor interactions, alignments and phylogenetic bushes. The substrate cleavage assortment has been assembled from the literature and consists of physiological, pathological and non-physiological cleavages in proteins, peptides and artificial substrates.
Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Sign Peptidase
Medical growth of antibiotics with novel mechanisms of motion to kill pathogenic micro organism is difficult, partially, as a result of inevitable emergence of resistance. A phenomenon of potential scientific significance that’s broadly missed in preclinical growth is heteroresistance, an often-unstable phenotype through which subpopulations of bacterial cells present decreased antibiotic susceptibility relative to the dominant inhabitants. Right here, we describe a brand new globomycin analog, G0790, with potent exercise in opposition to the Escherichia coli kind II sign peptidase LspA and uncover two novel resistance mechanisms to G0790 within the scientific uropathogenic E. coli pressure CFT073.
Constructing on the earlier discovering that full deletion of Lpp, the foremost Gram-negative outer membrane lipoprotein, results in globomycin resistance, we additionally discover that an unexpectedly modest lower in Lpp ranges mediated by insertion-based disruption of regulatory parts is ample to confer G0790 resistance and enhance sensitivity to serum killing. As well as, we describe a heteroresistance phenotype mediated by genomic amplifications of lspA that lead to elevated LspA ranges ample to beat inhibition by G0790 in tradition.
These genomic amplifications are extremely unstable and are misplaced after as few as two subcultures within the absence of G0790, which locations amplification-containing resistant strains at excessive danger of being misclassified as prone by routine antimicrobial susceptibility testing. In abstract, our examine uncovers two vastly totally different mechanisms of resistance to LspA inhibitors in E. coli and emphasizes the significance of contemplating the potential impression of unstable and heterogenous phenotypes when creating antibiotics for scientific use.
IMPORTANCE Regardless of growing proof suggesting that antibiotic heteroresistance can result in remedy failure, the importance of this phenomena within the clinic is just not properly understood, as a result of many scientific antibiotic susceptibility testing approaches lack the decision wanted to reliably classify heteroresistant strains. Right here we current G0790, a brand new globomycin analog and potent inhibitor of the Escherichia coli kind II sign peptidase LspA. We reveal that along with beforehand identified mechanisms of resistance to LspA inhibitors, unstable genomic amplifications containing lspA can result in modest but biologically important will increase in LspA protein ranges that confer a heteroresistance phenotype.
Dipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus
Molecular cloning and characterization of a novel peptidase from Trichinella spiralis and protecting immunity elicited by the peptidase in BALB/c mice
In our earlier research, a novel T. spiralis peptidase (TsP) was recognized among the many excretory/secretory (ES) proteins of T. spiralis intestinal infective larvae (IIL) and T. spiralis on the grownup worm (AW) stage utilizing immunoproteomics, however the organic perform of TsP within the life cycle of T. spiralis is just not clear. The target of this examine was to research the organic properties and features of TsP in larval intrusion and protecting immunity induced by immunization with rTsP. The whole TsP cDNA sequence was cloned and expressed.
The outcomes of RT-PCR, oblique immunofluorescence assay (IIFA) and western blotting revealed that TsP is a floor and secretory protein expressed in T. spiralis at totally different levels (muscle larvae, IIL, AWs and new child larvae) that’s principally localized on the epicuticle of the nematode. rTsP facilitated the larval intrusion of intestinal epithelial cells (IECs) and intestinal mucosa, whereas anti-rTsP antibodies suppressed larval intrusion; these facilitative and suppressive roles had been dose-dependently associated to rTsP or anti-rTsP antibodies.
 SERPINH1 Antibody |
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1-CSB-PA021087ESR2HU |
Cusabio |
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Description: A polyclonal antibody against SERPINH1. Recognizes SERPINH1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:50-1:200 |
SERPINH1 Antibody |
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1-CSB-PA021087GA01HU |
Cusabio |
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Description: A polyclonal antibody against SERPINH1. Recognizes SERPINH1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
 Serpinh1 Antibody |
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1-CSB-PA021087LA01MO |
Cusabio |
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Description: A polyclonal antibody against Serpinh1. Recognizes Serpinh1 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:500-1:2000 |
 SERPINH1 Conjugated Antibody |
|
C32687 |
SAB |
100ul |
EUR 476.4 |
 SERPINH1 Conjugated Antibody |
|
C43691 |
SAB |
100ul |
EUR 476.4 |
 Anti-SERPINH1 antibody |
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STJ115435 |
St John's Laboratory |
100 µl |
EUR 332.4 |
|
Description: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. |
Anti-SERPINH1 antibody |
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STJ11100256 |
St John's Laboratory |
100 µl |
EUR 471.6 |
|
Description: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. |
 Serpinh1 Polyclonal Antibody |
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A60854 |
EpiGentek |
-
EUR 684.66
-
EUR 117.70
-
EUR 302.50
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
 Antibody) Serpin H1 (SERPINH1) Antibody |
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20-abx001958 |
Abbexa |
-
EUR 493.20
-
EUR 710.40
-
EUR 218.40
-
EUR 376.80
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- 100 ul
- 200 ul
- 20 ul
- 50 ul
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 Antibody) Serpin H1 (Serpinh1) Antibody |
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20-abx319337 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
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) Polyclonal SERPINH1 Antibody (Center) |
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APR05898G |
Leading Biology |
0.1ml |
EUR 580.8 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SERPINH1 (Center). This antibody is tested and proven to work in the following applications: |
 Serpinh1 Antibody, HRP conjugated |
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1-CSB-PA021087LB01MO |
Cusabio |
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Description: A polyclonal antibody against Serpinh1. Recognizes Serpinh1 from Mouse. This antibody is HRP conjugated. Tested in the following application: ELISA |
 Serpinh1 Antibody, FITC conjugated |
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1-CSB-PA021087LC01MO |
Cusabio |
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Description: A polyclonal antibody against Serpinh1. Recognizes Serpinh1 from Mouse. This antibody is FITC conjugated. Tested in the following application: ELISA |
 Serpinh1 Antibody, Biotin conjugated |
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1-CSB-PA021087LD01MO |
Cusabio |
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Description: A polyclonal antibody against Serpinh1. Recognizes Serpinh1 from Mouse. This antibody is Biotin conjugated. Tested in the following application: ELISA |
 (OKEH06315)) SERPINH1 ELISA Kit (Rat) (OKEH06315) |
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OKEH06315 |
Aviva Systems Biology |
96 Wells |
EUR 794.4 |
|
Description: Description of target: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. ;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.78 ng/mL |
 (pORF)) Serpinh1 ORF Vector (Rat) (pORF) |
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ORF076093 |
ABM |
1.0 ug DNA |
EUR 607.2 |
 (OKCA02556)) SERPINH1 ELISA Kit (Rat) (OKCA02556) |
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OKCA02556 |
Aviva Systems Biology |
96 Wells |
EUR 1116 |
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Description: Description of target: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. ;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: 0.039 ng/mL |
) Custom production of antibodies in 5 Rats using customer supplied antigen (std 63 days protocol) |
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RAT-5 |
Alpha Diagnostics |
1 |
EUR 1365.6 |
 SERPINH1 Blocking Peptide |
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33R-2012 |
Fitzgerald |
100 ug |
EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SERPINH1 antibody, catalog no. 20R-1310 |
 Antibody (HRP)) Serpin H1 (Serpinh1) Antibody (HRP) |
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20-abx319096 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
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 Antibody (FITC)) Serpin H1 (Serpinh1) Antibody (FITC) |
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20-abx319097 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
 Antibody (Biotin)) Serpin H1 (Serpinh1) Antibody (Biotin) |
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20-abx319098 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
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) Polyclonal SERPINH1 Antibody (C-term) |
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APR05897G |
Leading Biology |
0.1ml |
EUR 580.8 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SERPINH1 (C-term). This antibody is tested and proven to work in the following applications: |
 Serpinh1 Polyclonal Antibody, Biotin Conjugated |
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A60855 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
|
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 Serpinh1 Polyclonal Antibody, FITC Conjugated |
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A60856 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
|
|
 Serpinh1 Polyclonal Antibody, HRP Conjugated |
|
A60857 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
|
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 ELISA kit) Rat Serpin H1(SERPINH1) ELISA kit |
|
E02S0361-192T |
BlueGene |
192 tests |
EUR 1524 |
|
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Description: A competitive ELISA for quantitative measurement of Rat Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Serpin H1(SERPINH1) ELISA kit |
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E02S0361-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
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Description: A competitive ELISA for quantitative measurement of Rat Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Serpin H1(SERPINH1) ELISA kit |
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E02S0361-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
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Description: A competitive ELISA for quantitative measurement of Rat Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
) Serpinh1 sgRNA CRISPR Lentivector set (Rat) |
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K6768901 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
 Polyclonal SERPINH1 antibody - C-terminal region |
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APR01904G |
Leading Biology |
0.1mg |
EUR 580.8 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SERPINH1 - C-terminal region. This antibody is tested and proven to work in the following applications: |
) Mouse Serpin H1 (Serpinh1) |
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1-CSB-EP021087MO |
Cusabio |
-
EUR 606.00
-
EUR 318.00
-
EUR 2192.40
-
EUR 919.20
-
EUR 1461.60
-
EUR 402.00
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
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Description: Recombinant Mouse Serpin H1(Serpinh1) expressed in E.coli |
Mouse Serpin H1 (Serpinh1) |
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1-CSB-YP021087MO |
Cusabio |
-
EUR 604.80
-
EUR 318.00
-
EUR 2198.40
-
EUR 915.60
-
EUR 1459.20
-
EUR 400.80
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
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Description: Recombinant Mouse Serpin H1(Serpinh1) expressed in Yeast |
 (Target 1)) Serpinh1 sgRNA CRISPR Lentivector (Rat) (Target 1) |
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K6768902 |
ABM |
1.0 ug DNA |
EUR 184.8 |
 (Target 2)) Serpinh1 sgRNA CRISPR Lentivector (Rat) (Target 2) |
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K6768903 |
ABM |
1.0 ug DNA |
EUR 184.8 |
 (Target 3)) Serpinh1 sgRNA CRISPR Lentivector (Rat) (Target 3) |
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K6768904 |
ABM |
1.0 ug DNA |
EUR 184.8 |
 (pPB-C-His)) SERPINH1 Protein Vector (Rat) (pPB-C-His) |
|
PV304370 |
ABM |
500 ng |
EUR 723.6 |
 (pPB-N-His)) SERPINH1 Protein Vector (Rat) (pPB-N-His) |
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PV304371 |
ABM |
500 ng |
EUR 723.6 |
 (pPM-C-HA)) SERPINH1 Protein Vector (Rat) (pPM-C-HA) |
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PV304372 |
ABM |
500 ng |
EUR 723.6 |
 (pPM-C-His)) SERPINH1 Protein Vector (Rat) (pPM-C-His) |
|
PV304373 |
ABM |
500 ng |
EUR 723.6 |
 (CMV) (pLenti-GIII-CMV)) SERPINH1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV) |
|
LV659533 |
ABM |
1.0 ug DNA |
EUR 818.4 |
 (UbC) (pLenti-GIII-UbC)) SERPINH1 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC) |
|
LV659537 |
ABM |
1.0 ug DNA |
EUR 818.4 |
 (EF1a) (pLenti-GIII-EF1a)) SERPINH1 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a) |
|
LV659538 |
ABM |
1.0 ug DNA |
EUR 818.4 |
 (OKAN06611)) SERPINH1 ELISA Kit (Human) (OKAN06611) |
|
OKAN06611 |
Aviva Systems Biology |
96 Wells |
EUR 950.4 |
|
Description: Description of target: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 50 pg/mL |
 (OKEH04176)) SERPINH1 ELISA Kit (Human) (OKEH04176) |
|
OKEH04176 |
Aviva Systems Biology |
96 Wells |
EUR 794.4 |
|
Description: Description of target: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 100 pg/mL |
 (pORF)) Serpinh1 ORF Vector (Mouse) (pORF) |
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ORF057064 |
ABM |
1.0 ug DNA |
EUR 607.2 |
Serpinh1 ORF Vector (Mouse) (pORF) |
|
ORF057065 |
ABM |
1.0 ug DNA |
EUR 607.2 |
Serpinh1 ORF Vector (Mouse) (pORF) |
|
ORF057066 |
ABM |
1.0 ug DNA |
EUR 607.2 |
 (OKEH03077)) SERPINH1 ELISA Kit (Mouse) (OKEH03077) |
|
OKEH03077 |
Aviva Systems Biology |
96 Wells |
EUR 888 |
|
Description: Description of target: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 40.1 pg/mL |
 (pORF)) SERPINH1 ORF Vector (Human) (pORF) |
|
ORF009400 |
ABM |
1.0 ug DNA |
EUR 114 |
 (OKCD06194)) SERPINH1 ELISA Kit (Human) (OKCD06194) |
|
OKCD06194 |
Aviva Systems Biology |
96 Wells |
EUR 903.6 |
|
Description: Description of target: Serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1);Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 46pg/mL |
 ELISA kit) Goat Serpin H1(SERPINH1) ELISA kit |
|
E06S0361-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Goat Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Serpin H1(SERPINH1) ELISA kit |
|
E06S0361-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Goat Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Serpin H1(SERPINH1) ELISA kit |
|
E06S0361-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Goat Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 ELISA kit) Rabbit Serpin H1(SERPINH1) ELISA kit |
|
E04S0361-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rabbit Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Serpin H1(SERPINH1) ELISA kit |
|
E04S0361-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rabbit Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Serpin H1(SERPINH1) ELISA kit |
|
E04S0361-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rabbit Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 ELISA kit) Mouse Serpin H1(SERPINH1) ELISA kit |
|
E03S0361-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Serpin H1(SERPINH1) ELISA kit |
|
E03S0361-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Serpin H1(SERPINH1) ELISA kit |
|
E03S0361-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Mouse Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 ELISA Kit) Human SERPINH1(Serpin H1) ELISA Kit |
|
EH0812 |
FN Test |
96T |
EUR 681.12 |
|
|
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.075 ng/ml |
 ELISA kit) Dog Serpin H1(SERPINH1) ELISA kit |
|
E08S0361-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Canine Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Serpin H1(SERPINH1) ELISA kit |
|
E08S0361-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Canine Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Serpin H1(SERPINH1) ELISA kit |
|
E08S0361-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Canine Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 ELISA kit) Monkey Serpin H1(SERPINH1) ELISA kit |
|
E09S0361-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Monkey Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Serpin H1(SERPINH1) ELISA kit |
|
E09S0361-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Monkey Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Serpin H1(SERPINH1) ELISA kit |
|
E09S0361-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Monkey Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 ELISA kit) Human Serpin H1(SERPINH1) ELISA kit |
|
E01S0361-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Human Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Serpin H1(SERPINH1) ELISA kit |
|
E01S0361-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Human Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Serpin H1(SERPINH1) ELISA kit |
|
E01S0361-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
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Description: A competitive ELISA for quantitative measurement of Human Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 ELISA kit) Pig Serpin H1(SERPINH1) ELISA kit |
|
E07S0361-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Porcine Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Serpin H1(SERPINH1) ELISA kit |
|
E07S0361-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Porcine Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Serpin H1(SERPINH1) ELISA kit |
|
E07S0361-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
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|
Description: A competitive ELISA for quantitative measurement of Porcine Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
) SERPINH1 sgRNA CRISPR Lentivector set (Human) |
|
K2126401 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
) Serpinh1 sgRNA CRISPR Lentivector set (Mouse) |
|
K4997301 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
) Serpinh1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat) |
|
K6768905 |
ABM |
3 x 1.0 ug |
EUR 451.2 |
 ELISA kit) Guinea pig Serpin H1(SERPINH1) ELISA kit |
|
E05S0361-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Guinea pig Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig Serpin H1(SERPINH1) ELISA kit |
|
E05S0361-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Guinea pig Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig Serpin H1(SERPINH1) ELISA kit |
|
E05S0361-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Guinea pig Serpin H1(SERPINH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 (Target 1)) SERPINH1 sgRNA CRISPR Lentivector (Human) (Target 1) |
|
K2126402 |
ABM |
1.0 ug DNA |
EUR 184.8 |
 (Target 2)) SERPINH1 sgRNA CRISPR Lentivector (Human) (Target 2) |
|
K2126403 |
ABM |
1.0 ug DNA |
EUR 184.8 |
 (Target 3)) SERPINH1 sgRNA CRISPR Lentivector (Human) (Target 3) |
|
K2126404 |
ABM |
1.0 ug DNA |
EUR 184.8 |
) ELISA kit for Human Serpin H1 (SERPINH1) |
|
KTE60689-48T |
Abbkine |
48T |
EUR 398.4 |
|
|
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Description: Quantitative sandwich ELISA for measuring Human Serpin H1 (SERPINH1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human Serpin H1 (SERPINH1) |
|
KTE60689-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2538 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Human Serpin H1 (SERPINH1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human Serpin H1 (SERPINH1) |
|
KTE60689-96T |
Abbkine |
96T |
EUR 646.8 |
|
|
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Description: Quantitative sandwich ELISA for measuring Human Serpin H1 (SERPINH1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
 (Target 1)) Serpinh1 sgRNA CRISPR Lentivector (Mouse) (Target 1) |
|
K4997302 |
ABM |
1.0 ug DNA |
EUR 184.8 |
 (Target 2)) Serpinh1 sgRNA CRISPR Lentivector (Mouse) (Target 2) |
|
K4997303 |
ABM |
1.0 ug DNA |
EUR 184.8 |
 (Target 3)) Serpinh1 sgRNA CRISPR Lentivector (Mouse) (Target 3) |
|
K4997304 |
ABM |
1.0 ug DNA |
EUR 184.8 |
 (pPB-C-His)) SERPINH1 Protein Vector (Human) (pPB-C-His) |
|
PV037597 |
ABM |
500 ng |
EUR 394.8 |
 (pPB-N-His)) SERPINH1 Protein Vector (Human) (pPB-N-His) |
|
PV037598 |
ABM |
500 ng |
EUR 394.8 |
 (pPM-C-HA)) SERPINH1 Protein Vector (Human) (pPM-C-HA) |
|
PV037599 |
ABM |
500 ng |
EUR 394.8 |
 (pPM-C-His)) SERPINH1 Protein Vector (Human) (pPM-C-His) |
|
PV037600 |
ABM |
500 ng |
EUR 394.8 |
 SERPINH1 Heat Shock 47kDa Human Recombinant Protein |
|
PROTP50454 |
BosterBio |
Regular: 50ug |
EUR 380.4 |
|
Description: Recombinant Human HSP47 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 422 amino acids (18-418 a.a) and having a molecular mass of 46.8kDa. ;HSP47 human recombinant is fused to a 20 amino acid His Tag at N-terminus and purified by convential chromatogrpahy techniques. |
 (pPB-C-His)) SERPINH1 Protein Vector (Mouse) (pPB-C-His) |
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PV228254 |
ABM |
500 ng |
EUR 723.6 |
 (pPB-N-His)) SERPINH1 Protein Vector (Mouse) (pPB-N-His) |
|
PV228255 |
ABM |
500 ng |
EUR 723.6 |
 (pPM-C-HA)) SERPINH1 Protein Vector (Mouse) (pPM-C-HA) |
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PV228256 |
ABM |
500 ng |
EUR 723.6 |
 (pPM-C-His)) SERPINH1 Protein Vector (Mouse) (pPM-C-His) |
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PV228257 |
ABM |
500 ng |
EUR 723.6 |
SERPINH1 Protein Vector (Mouse) (pPB-C-His) |
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PV228258 |
ABM |
500 ng |
EUR 723.6 |
SERPINH1 Protein Vector (Mouse) (pPB-N-His) |
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PV228259 |
ABM |
500 ng |
EUR 723.6 |
SERPINH1 Protein Vector (Mouse) (pPM-C-HA) |
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PV228260 |
ABM |
500 ng |
EUR 723.6 |
SERPINH1 Protein Vector (Mouse) (pPM-C-His) |
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PV228261 |
ABM |
500 ng |
EUR 723.6 |
SERPINH1 Protein Vector (Mouse) (pPB-C-His) |
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PV228262 |
ABM |
500 ng |
EUR 723.6 |
SERPINH1 Protein Vector (Mouse) (pPB-N-His) |
|
PV228263 |
ABM |
500 ng |
EUR 723.6 |
Immunization of mice with rTsP triggered an apparent humoral immune response (excessive ranges of IgG, IgG1/IgG2a, and sIgA) and likewise elicited systemic (spleen) and intestinal native mucosal (mesenteric lymph node) mobile immune responses, as demonstrated by an evident enhance within the cytokines IFN-γ and IL-4. Immunization of mice with rTsP diminished the numbers of intestinal grownup worms by 38.6% and muscle larvae by 41.93%. These outcomes reveal that TsP performs an important function within the intrusion, growth and survival of T. spiralis in hosts and is a promising candidate goal molecule for anti-Trichinella vaccines.
