Dipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus
Dipeptidyl peptidase Four inhibitors (DPP4i) have been out there for treating kind 2 diabetes mellitus since 2006. Though they’re a various group, DPP4i are all small, orally out there molecules that work together with the catalytic website of DPP4 with out disturbing any of its different identified features, together with its results on the immune system. DPP4i don’t have any intrinsic glucose-lowering exercise, so their efficacy as anti-diabetic brokers is said on to their capability to inhibit DPP4 exercise and is mediated by way of the consequences of the substrates they defend. Of those, the incretin hormone, glucagon-like peptide 1, might be crucial. As the consequences of glucagon-like peptide 1 are glucose-dependent, the chance of hypoglycaemia with DPP4i is low.
Class results, that are instantly associated to the mechanism of motion, are frequent to all DPP4i; these embrace their total good security profile and tolerability, in addition to their efficacy in enhancing glycaemic management, but additionally, doubtlessly, a small elevated danger of acute pancreatitis. Compound-specific results are these associated to their differing chemistries and/or pharmacokinetic profiles. These compound-specific results may have an effect on the best way through which particular person DPP4i are used therapeutically and doubtlessly clarify off-target antagonistic results, comparable to hospitalization for coronary heart failure, which is seen solely with one DPP4i. General, DPP4i have a beneficial therapeutic profile and are protected and efficient within the majority of sufferers with kind 2 diabetes mellitus. Households through which the proteins share related tertiary buildings are assembled right into a clan.
The MEROPS classification is thus a hierarchy with at the very least three ranges (protein-species, household and clan) displaying the evolutionary relationship. A number of different knowledge collections have been assembled that are accessed from all ranges within the hierarchy. These embrace, sequence homologues, selective bibliographies, substrate cleavage websites, peptidase-inhibitor interactions, alignments and phylogenetic bushes. The substrate cleavage assortment has been assembled from the literature and consists of physiological, pathological and non-physiological cleavages in proteins, peptides and artificial substrates.
Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Sign Peptidase
Molecular cloning and characterization of a novel peptidase from Trichinella spiralis and protecting immunity elicited by the peptidase in BALB/c mice
Rat Serpinh1 Antibody (Center) |
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MBS9200175-5x04mL | MyBiosource | 5x0.4mL | EUR 1910 |
SERPINH1 antibody |
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20R-1310 | Fitzgerald | 100 ug | EUR 407 |
Description: Rabbit polyclonal SERPINH1 antibody |
SERPINH1 Antibody |
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32687-100ul | SAB | 100ul | EUR 302.4 |
SERPINH1 Antibody |
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43691 | SAB | 100ul | EUR 319 |
SERPINH1 Antibody |
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43691-100ul | SAB | 100ul | EUR 302.4 |
SERPINH1 Antibody |
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E043691 | EnoGene | 100μg/100μl | EUR 255 |
Description: Available in various conjugation types. |
SERPINH1 Antibody |
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E19-6980 | EnoGene | 100μg/100μl | EUR 225 |
Description: Available in various conjugation types. |
SERPINH1 Antibody |
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1-CSB-PA021087ESR2HU | Cusabio |
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Description: A polyclonal antibody against SERPINH1. Recognizes SERPINH1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:50-1:200 |
SERPINH1 Antibody |
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1-CSB-PA021087GA01HU | Cusabio |
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Description: A polyclonal antibody against SERPINH1. Recognizes SERPINH1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
Serpinh1 Antibody |
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1-CSB-PA021087LA01MO | Cusabio |
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Description: A polyclonal antibody against Serpinh1. Recognizes Serpinh1 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:500-1:2000 |
SERPINH1 Antibody |
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DF6980 | Affbiotech | 200ul | EUR 420 |
SERPINH1 Antibody |
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DF6980-100ul | Affinity Biosciences | 100ul | EUR 280 |
SERPINH1 Antibody |
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DF6980-200ul | Affinity Biosciences | 200ul | EUR 350 |
SERPINH1 Antibody |
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E92517 | EnoGene | 100μg | EUR 255 |
Description: Available in various conjugation types. |
SERPINH1 Antibody |
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CAC10563-100ul | Biomatik Corporation | 100ul | EUR 314 |
SERPINH1 Antibody |
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CAC10563-50ul | Biomatik Corporation | 50ul | EUR 199.2 |
SERPINH1 antibody |
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70R-20182 | Fitzgerald | 50 ul | EUR 289 |
Description: Rabbit polyclonal SERPINH1 antibody |
SERPINH1 Antibody |
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ABD6980 | Nova Lifetech | 100ug | EUR 325 |
Serpinh1 Antibody |
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F40219-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
Description: Serpinh1 binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. [UniProt] |
SERPINH1 Antibody |
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GWB-A76A5E | GenWay Biotech | 0.1 mg | Ask for price |
SERPINH1 Antibody |
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MBS7136722-005mL | MyBiosource | 0.05mL | EUR 220 |
SERPINH1 Antibody |
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MBS7136722-01mL | MyBiosource | 0.1mL | EUR 300 |
SERPINH1 Antibody |
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MBS7136722-5x01mL | MyBiosource | 5x0.1mL | EUR 1350 |
SERPINH1 antibody |
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MBS835022-01mL | MyBiosource | 0.1mL | EUR 660 |
SERPINH1 antibody |
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MBS835022-5x01mL | MyBiosource | 5x0.1mL | EUR 2820 |
SERPINH1 Antibody |
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MBS8516450-01mg | MyBiosource | 0.1mg | EUR 305 |
SERPINH1 Antibody |
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MBS8516450-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 465 |
SERPINH1 Antibody |
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MBS8516450-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 465 |
SERPINH1 Antibody |
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MBS8516450-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 465 |
SERPINH1 Antibody |
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MBS8516450-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 465 |
SERPINH1 Antibody |
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MBS8503028-01mg | MyBiosource | 0.1mg | EUR 325 |
SERPINH1 Antibody |
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MBS8503028-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
SERPINH1 Antibody |
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MBS8503028-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
SERPINH1 Antibody |
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MBS8503028-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
SERPINH1 Antibody |
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MBS8503028-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
Serpinh1 Antibody |
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MBS1497863-005mg | MyBiosource | 0.05mg | EUR 190 |
Serpinh1 Antibody |
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MBS1497863-01mg | MyBiosource | 0.1mg | EUR 270 |
Serpinh1 Antibody |
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MBS1497863-5x01mg | MyBiosource | 5x0.1mg | EUR 1205 |
SERPINH1 Antibody |
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MBS9417110-01mL | MyBiosource | 0.1mL | EUR 305 |
SERPINH1 Antibody |
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MBS9417110-5x01mL | MyBiosource | 5x0.1mL | EUR 1230 |
SERPINH1 Antibody |
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MBS9607633-01mL | MyBiosource | 0.1mL | EUR 260 |
SERPINH1 Antibody |
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MBS9607633-02mL | MyBiosource | 0.2mL | EUR 305 |
SERPINH1 Antibody |
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MBS9607633-5x02mL | MyBiosource | 5x0.2mL | EUR 1220 |
Hsp47 Antibody (Serpinh1) |
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F40219-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: Serpinh1 binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. [UniProt] |
SERPINH1 Antibody (Center) |
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MBS9208399-008mL | MyBiosource | 0.08mL | EUR 210 |
SERPINH1 Antibody (Center) |
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MBS9208399-04mL | MyBiosource | 0.4mL | EUR 430 |
SERPINH1 Antibody (Center) |
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MBS9208399-5x04mL | MyBiosource | 5x0.4mL | EUR 1910 |
Serpin H1 (SERPINH1) Antibody |
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20-abx115477 | Abbexa |
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Serpin H1 (SERPINH1) Antibody |
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abx033355-400ul | Abbexa | 400 ul | EUR 627.6 |
Serpin H1 (SERPINH1) Antibody |
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abx033355-80l | Abbexa | 80 µl | EUR 343.2 |
Serpin H1 (SERPINH1) Antibody |
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abx033356-400ul | Abbexa | 400 ul | EUR 627.6 |
Serpin H1 (SERPINH1) Antibody |
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abx033356-80l | Abbexa | 80 µl | EUR 343.2 |
Serpin H1 (SERPINH1) Antibody |
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20-abx001958 | Abbexa |
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Serpin H1 (Serpinh1) Antibody |
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20-abx319337 | Abbexa |
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Serpin H1 (SERPINH1) Antibody |
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20-abx321407 | Abbexa |
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Serpin H1 (SERPINH1) Antibody |
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abx115477-100l | Abbexa | 100 µl | EUR 612.5 |
Serpin H1 (SERPINH1) Antibody |
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abx033355-100g | Abbexa | 100 µg | EUR 281.25 |
Serpin H1 (SERPINH1) Antibody |
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abx033356-100g | Abbexa | 100 µg | EUR 281.25 |
Serpin H1 (SERPINH1) Antibody |
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abx148964-1096tests | Abbexa | 10 × 96 tests | Ask for price |
Serpin H1 (SERPINH1) Antibody |
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abx148964-596tests | Abbexa | 5 × 96 tests | Ask for price |
Serpin H1 (SERPINH1) Antibody |
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abx148964-96tests | Abbexa | 96 tests | EUR 350 |
Serpin H1 (SERPINH1) Antibody |
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abx321407-100g | Abbexa | 100 µg | EUR 350 |
Serpin H1 (SERPINH1) Antibody |
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abx321407-50g | Abbexa | 50 µg | EUR 237.5 |
Serpin H1 (SERPINH1) Antibody |
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abx402372-200g | Abbexa | 200 µg | EUR 287.5 |
Serpin H1 (Serpinh1) Antibody |
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abx319337-100l | Abbexa | 100 µl | EUR 250 |
Serpin H1 (Serpinh1) Antibody |
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abx319337-50l | Abbexa | 50 µl | EUR 162.5 |
Serpin H1 (SERPINH1) Antibody |
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abx001958-100l | Abbexa | 100 µl | EUR 400 |
Serpin H1 (SERPINH1) Antibody |
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abx001958-20l | Abbexa | 20 µl | EUR 175 |
Serpin H1 (SERPINH1) Antibody |
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abx001958-50l | Abbexa | 50 µl | EUR 275 |
Serpinh1 Polyclonal Antibody |
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A60854 | EpiGentek |
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SERPINH1 Conjugated Antibody |
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C32687 | SAB | 100ul | EUR 476.4 |
SERPINH1 Conjugated Antibody |
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C43691 | SAB | 100ul | EUR 476.4 |
SERPINH1 Polyclonal Antibody |
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E-AB-19472-120uL | Elabscience Biotech | 120uL | EUR 240 |
Description: Unconjugated |
SERPINH1 Polyclonal Antibody |
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E-AB-19472-200uL | Elabscience Biotech | 200uL | EUR 399 |
Description: Unconjugated |
SERPINH1 Polyclonal Antibody |
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E-AB-19472-20uL | Elabscience Biotech | 20uL | EUR 73 |
Description: Unconjugated |
SERPINH1 Polyclonal Antibody |
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E-AB-19472-60uL | Elabscience Biotech | 60uL | EUR 143 |
Description: Unconjugated |
SERPINH1 Polyclonal Antibody |
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MBS129379-002mL | MyBiosource | 0.02mL | EUR 200 |
SERPINH1 Polyclonal Antibody |
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MBS129379-005mL | MyBiosource | 0.05mL | EUR 255 |
SERPINH1 Polyclonal Antibody |
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MBS129379-01mL | MyBiosource | 0.1mL | EUR 345 |
SERPINH1 Polyclonal Antibody |
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MBS129379-02mL | MyBiosource | 0.2mL | EUR 545 |
SERPINH1 Polyclonal Antibody |
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MBS129379-5x02mL | MyBiosource | 5x0.2mL | EUR 2265 |
SERPINH1 Polyclonal Antibody |
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E-AB-53454-120uL | Elabscience Biotech | 120uL | EUR 240 |
Description: Unconjugated |
SERPINH1 Polyclonal Antibody |
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E-AB-53454-200uL | Elabscience Biotech | 200uL | EUR 399 |
Description: Unconjugated |
SERPINH1 Polyclonal Antibody |
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E-AB-53454-20uL | Elabscience Biotech | 20uL | EUR 73 |
Description: Unconjugated |
SERPINH1 Polyclonal Antibody |
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E-AB-53454-60uL | Elabscience Biotech | 60uL | EUR 143 |
Description: Unconjugated |
SERPINH1 Polyclonal Antibody |
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MBS9133514-002mL | MyBiosource | 0.02mL | EUR 200 |
SERPINH1 Polyclonal Antibody |
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MBS9133514-005mL | MyBiosource | 0.05mL | EUR 255 |
SERPINH1 Polyclonal Antibody |
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MBS9133514-01mL | MyBiosource | 0.1mL | EUR 345 |
SERPINH1 Polyclonal Antibody |
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MBS9133514-02mL | MyBiosource | 0.2mL | EUR 545 |
SERPINH1 Polyclonal Antibody |
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MBS9133514-5x02mL | MyBiosource | 5x0.2mL | EUR 2265 |
SERPINH1 Polyclonal Antibody |
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MBS2563356-002mL | MyBiosource | 0.02mL | EUR 135 |
SERPINH1 Polyclonal Antibody |
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MBS2563356-006mL | MyBiosource | 0.06mL | EUR 190 |
SERPINH1 Polyclonal Antibody |
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MBS2563356-012mL | MyBiosource | 0.12mL | EUR 265 |
SERPINH1 Polyclonal Antibody |
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MBS2563356-02mL | MyBiosource | 0.2mL | EUR 415 |
SERPINH1 Polyclonal Antibody |
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MBS2563356-5x02mL | MyBiosource | 5x0.2mL | EUR 1835 |
SERPINH1 Polyclonal Antibody |
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MBS2561361-002mL | MyBiosource | 0.02mL | EUR 135 |
SERPINH1 Polyclonal Antibody |
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MBS2561361-006mL | MyBiosource | 0.06mL | EUR 190 |
SERPINH1 Polyclonal Antibody |
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MBS2561361-012mL | MyBiosource | 0.12mL | EUR 265 |
SERPINH1 Polyclonal Antibody |
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MBS2561361-02mL | MyBiosource | 0.2mL | EUR 415 |
SERPINH1 Polyclonal Antibody |
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MBS2561361-5x02mL | MyBiosource | 5x0.2mL | EUR 1835 |
SERPINH1 Conjugated Antibody |
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MBS9451945-01mLAF350 | MyBiosource | 0.1mL(AF350) | EUR 480 |
SERPINH1 Conjugated Antibody |
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MBS9451945-01mLAF405 | MyBiosource | 0.1mL(AF405) | EUR 480 |
SERPINH1 Conjugated Antibody |
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MBS9451945-01mLAF488 | MyBiosource | 0.1mL(AF488) | EUR 480 |
SERPINH1 Conjugated Antibody |
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MBS9451945-01mLAF555 | MyBiosource | 0.1mL(AF555) | EUR 480 |
SERPINH1 Conjugated Antibody |
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MBS9451945-01mLBiotin | MyBiosource | 0.1mL(Biotin) | EUR 480 |
SERPINH1 Polyclonal Antibody |
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RD219472A-120uL | Reddot Biotech | 120μL | EUR 360 |
Description: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. |
SERPINH1 Polyclonal Antibody |
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RD219472A-200uL | Reddot Biotech | 200μL | EUR 630 |
Description: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. |
SERPINH1 Polyclonal Antibody |
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RD219472A-20uL | Reddot Biotech | 20μL | EUR 109.5 |
Description: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. |
SERPINH1 Polyclonal Antibody |
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RD219472A-60uL | Reddot Biotech | 60μL | EUR 214.5 |
Description: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. |
SERPINH1 Polyclonal Antibody |
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RD253454A-120uL | Reddot Biotech | 120μL | EUR 360 |
Description: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. |
SERPINH1 Polyclonal Antibody |
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RD253454A-200uL | Reddot Biotech | 200μL | EUR 630 |
Description: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. |
SERPINH1 Polyclonal Antibody |
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RD253454A-20uL | Reddot Biotech | 20μL | EUR 109.5 |
Description: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. |
SERPINH1 Polyclonal Antibody |
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RD253454A-60uL | Reddot Biotech | 60μL | EUR 214.5 |
Description: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. |
Serpin B3 (SERPINB3) Monoclonal Antibody |
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CAU30338-100ul | Biomatik Corporation | 100ul | EUR 236.2 |
Serpin B3 (SERPINB3) Monoclonal Antibody |
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CAU30338-200ul | Biomatik Corporation | 200ul | EUR 295.7 |
SERPINA Monoclonal Antibody |
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E10-32009 | EnoGene | 100μg/100μl | EUR 225 |
Description: Available in various conjugation types. |
SERPINH1 Antibody (C-term) |
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MBS9212684-008mL | MyBiosource | 0.08mL | EUR 210 |
SERPINH1 Antibody (C-term) |
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MBS9212684-04mL | MyBiosource | 0.4mL | EUR 430 |
SERPINH1 Antibody (C-term) |
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MBS9212684-5x04mL | MyBiosource | 5x0.4mL | EUR 1910 |
SERPINH1 antibody | AB01/3C1 |
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MBS226472-01mL | MyBiosource | 0.1mL | EUR 485 |
SERPINH1 antibody | AB01/3C1 |
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MBS226472-5x01mL | MyBiosource | 5x0.1mL | EUR 2015 |
SERPINA1 Monoclonal Antibody |
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E10-31866P | EnoGene | 100μg/100μl | EUR 225 |
Description: Available in various conjugation types. |
Serpin A10 (SERPINA10) Monoclonal Antibody |
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CAU30340-100ul | Biomatik Corporation | 100ul | EUR 248.6 |
Serpin A10 (SERPINA10) Monoclonal Antibody |
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CAU30340-200ul | Biomatik Corporation | 200ul | EUR 310.8 |
Serpin H1 (Serpinh1) Antibody (HRP) |
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20-abx319096 | Abbexa |
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Serpin H1 (Serpinh1) Antibody (HRP) |
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abx319096-100l | Abbexa | 100 µl | EUR 250 |
Serpin H1 (Serpinh1) Antibody (HRP) |
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abx319096-50l | Abbexa | 50 µl | EUR 162.5 |
SERPINH1 siRNA (Rat) |
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MBS8216568-30nmol | MyBiosource | 30nmol | EUR 565 |
SERPINH1 siRNA (Rat) |
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MBS8216568-5x30nmol | MyBiosource | 5x30nmol | EUR 2450 |
SERPINH1 siRNA (Rat) |
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MBS8216568-15nmol | MyBiosource | 15nmol | EUR 405 |
Monoclonal Antibody to Serpin B3 (SERPINB3) |
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MAB372Hu21 | Cloud-Clone | 100ul | EUR 253 |
Monoclonal Antibody to Serpin B3 (SERPINB3) |
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MAB372Hu22 | Cloud-Clone | 100ul | EUR 246 |
Monoclonal Antibody to Serpin B3 (SERPINB3) |
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MAB372Hu23 | Cloud-Clone | 100ul | EUR 253 |
Monoclonal Antibody to Serpin B3 (SERPINB3) |
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MAB372Hu24 | Cloud-Clone | 100ul | EUR 255 |
Monoclonal Antibody to Serpin B3 (SERPINB3) |
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MBS2138913-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Monoclonal Antibody to Serpin B3 (SERPINB3) |
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MBS2138914-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Serpin H1 (Serpinh1) Antibody (FITC) |
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20-abx319097 | Abbexa |
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Serpin H1 (Serpinh1) Antibody (FITC) |
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abx319097-100l | Abbexa | 100 µl | EUR 250 |
Serpin H1 (Serpinh1) Antibody (FITC) |
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abx319097-50l | Abbexa | 50 µl | EUR 162.5 |
Anti-Hsp47/SERPINH1 Antibody |
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PB9325 | BosterBio | 100ug/vial | EUR 400.8 |
Serpin H1 (Serpinh1) Antibody (Biotin) |
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20-abx319098 | Abbexa |
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Serpin H1 (Serpinh1) Antibody (Biotin) |
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abx319098-100l | Abbexa | 100 µl | EUR 250 |
Serpin H1 (Serpinh1) Antibody (Biotin) |
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abx319098-50l | Abbexa | 50 µl | EUR 162.5 |