The Inhibitory Effect of 6-Gingerol on Ubiquitin-Specific Peptidase 14 Enhances Autophagy-Dependent Ferroptosis and Anti-Tumor in vivo and in vitro

The Inhibitory Effect of 6-Gingerol on Ubiquitin-Specific Peptidase 14 Enhances Autophagy-Dependent Ferroptosis and Anti-Tumor in vivo and in vitro

December 22, 2020 0 By Keith

Lung most cancers is the most typical malignant tumor and is the main reason for cancer-related deaths worldwide. Extraction of bioactive substances from herbs is taken into account in its place methodology to conventional remedy. 6-Gingerol is a naturally occurring phenol present in ginger that can be utilized to deal with tumors and suppress irritation.

To find out whether or not 6-Gingerol can be utilized as a therapeutic agent for tumors. On this research, tumor-bearing mice had been used as an animal mannequin and A549 as a cell mannequin. Western blot was used to detect the expression of autophagy associated proteins ubiquitin-specific peptidase 14 (USP14), Beclin1, microtubule-associated protein mild chain 3 (LC3) and ferroptosis associated proteins nuclear receptor coactivator 4 (NCOA4), ferritin heavy chain 1 (FTH1), transferrin receptor 1 (TfR1), glutathione peroxidase 4 (GPX4), activating transcription factor4 (ATF4) in vivo and in vitro. MTT and EdU had been used to detect the viability of A549 cells. H&E and immunofluorescence had been used to localize and detect the expression of proteins.

The detection of reactive oxygen species was carried out utilizing fluorescence probes. It was discovered that the administration of 6-Gingerol decreased the expression of USP14, vastly elevated the variety of autophagosomes, reactive oxygen species (ROS) and iron focus, decreased the survival and proliferation charge of A549 cells, and considerably decreased tumor quantity and weight. The outcomes point out that 6-Gingerol inhibits lung most cancers cell progress by way of suppression of USP14 expression and its downstream regulation of autophagy-dependent ferroptosis, revealing the perform and efficacy of 6-Gingerol as a therapeutic compound in A549 and its attainable mechanism of motion.

 

Arachidonic Acid Is a Secure and Efficacious Schistosomicide, and an Endoschistosomicide in Pure and Experimental Infections, and Cysteine Peptidase Vaccinated Hosts

Blood flukes of the genus Schistosoma are coated by a protecting heptalaminated, double lipid bilayer floor membrane. Giant quantities of sphingomyelin (SM) within the outer leaflet kind with surrounding water molecules a good hydrogen bond barrier, which permits entry of vitamins and prevents entry of host immune effectors. Extreme hydrolysis of SM to phosphoryl choline and ceramide by way of activation of the parasite tegument-associated impartial sphingomyelinase (nSMase) with the polyunsaturated fatty acid, arachidonic acid (ARA) results in parasite demise, by way of permitting publicity of apical membrane antigens to antibody-dependent cell-mediated cytotoxicity (ADCC), and accumulation of the pro-apoptotic ceramide.
Floor membrane nSMase represents, thus, a worm Achilles heel, and ARA a legitimate schistosomicide. A number of experiments carried out in vitro utilizing larval, juvenile, and grownup Schistosoma mansoni and Schistosoma haematobium documented ARA schistosomicidal potential. Arachidonic acid schistosomicidal motion was proven to be secure and efficacious in mice and hamsters contaminated with S. mansoni and S. haematobium, respectively, and in kids with mild S. mansoni an infection. A mix of praziquantel and ARA led to excellent remedy charges in kids with heavy S. mansoni an infection. Moreover, ample proof was obtained for the highly effective ARA ovocidal potential in vivo and in vitro in opposition to S. mansoni and S. haematobium liver and gut eggs. Research documented ARA as an endogenous schistosomicide within the ultimate mammalian and intermediate snail hosts, and in mice and hamsters, immunized with the cysteine peptidase-based vaccine.
These findings collectively help our advocating the nutrient ARA because the secure and efficacious schistosomicide of the long run. Endovascular and open thoraco-abdominal aortic aneurysm (TAAA) restore is related to particular problems. Circulating dipeptidyl peptidase 3 (cDPP3) is a novel biomarker that reveals a powerful affiliation with organ failure which has not been assessed in surgical settings. Subsequently, the target of this research was to evaluate the prognostic capabilities of cDPP3 for predicting affected person survival and organ failure following open and endovascular TAAA restore.
 The Inhibitory Effect of 6-Gingerol on Ubiquitin-Specific Peptidase 14 Enhances Autophagy-Dependent Ferroptosis and Anti-Tumor in vivo and in vitro

The Inhibitory Effect of 6-Gingerol on Ubiquitin-Specific Peptidase 14 Enhances Autophagy-Dependent Ferroptosis and Anti-Tumor in vivo and in vitro

Meta-Evaluation of 11 Heterogeneous Research concerning Dipeptidyl Peptidase Four Inhibitor Add-On Remedy for Sort 2 Diabetes Mellitus Sufferers Handled with Insulin

Background: A number of scientific trials have addressed the therapeutic technique of including dipeptidyl peptidase 4 (DPP-4) inhibitors to the remedy of sort 2 diabetes mellitus (DM) inadequately managed by insulin remedy. Nonetheless, there’s a excessive diploma of heterogeneity in these research, and the reason for which has not been recognized.
Strategies: We carried out a meta-analysis of randomized managed trials, which in contrast the efficacy and security of including DPP-Four inhibitors or placebo to insulin remedy; the extent of hemoglobin A1c  within the sufferers was >7.0%, and the period of remedy was ≥eight weeks. We centered on the imply adjustments in HbA1c from the baseline and the incidence of hypoglycemia. We assumed that 5 baseline parameters (HbA1c, fasting blood glucose, physique mass index (BMI), period of sort 2 DM, and period of remedy) might have an effect on ΔHbA1c. Concerning the incidence of hypoglycemia, we suspected that the heterogeneity was attributable to variations within the definition of hypoglycemia among the many research.
Outcomes: Knowledge obtained from 11 research had been included within the evaluation. The imply ΔHbA1c between the DPP-Four inhibitor and placebo teams was -0.61% . There was substantial heterogeneity among the many 11 research, however 74.1% of this variability was defined by the distinction in BMI. The chances ratio for the incidence of hypoglycemia was 1.02, with substantial heterogeneity as a result of variations within the definition of hypoglycemia among the many research. There was no obvious impact of publication bias.

SERPINI1 Antibody

1-CSB-PA859934LA01HU
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Description: A polyclonal antibody against SERPINI1. Recognizes SERPINI1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

SERPINI1 Antibody

CSB-PA869434- each
EUR 402
Description: A polyclonal antibody against SERPINI1. Recognizes SERPINI1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

SERPINI1 Antibody

CSB-PA869434-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against SERPINI1. Recognizes SERPINI1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

SERPINI1 Antibody

GWB-MU421G 50ug Ask for price

Neuroserpin (SERPINI1) Antibody

abx433030-200ul 200 ul
EUR 460.8

Neuroserpin (SERPINI1) Antibody

abx332186-100ul 100 ul
EUR 510

Neuroserpin (SERPINI1) Antibody

20-abx301904
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Neuroserpin (SERPINI1) Antibody

20-abx123763
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Neuroserpin (SERPINI1) Antibody

abx235681-100ug 100 ug
EUR 610.8

Neuroserpin (SERPINI1) Antibody

20-abx115478
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Neuroserpin (SERPINI1) Antibody

abx025697-400ul 400 ul
EUR 627.6

Neuroserpin (SERPINI1) Antibody

abx025697-80l 80 µl
EUR 343.2

Neuroserpin (SERPINI1) Antibody

abx235681-100g 100 µg
EUR 350

Neuroserpin (SERPINI1) Antibody

abx301904-100g 100 µg
EUR 362.5

Neuroserpin (SERPINI1) Antibody

abx301904-20g 20 µg
EUR 162.5

Neuroserpin (SERPINI1) Antibody

abx301904-50g 50 µg
EUR 250

Neuroserpin (SERPINI1) Antibody

abx115478-100l 100 µl
EUR 612.5

Neuroserpin (SERPINI1) Antibody

abx025697-400l 400 µl
EUR 518.75

Neuroserpin (SERPINI1) Antibody

abx433030-100g 100 µg
EUR 387.5

SERPINI1 Polyclonal Antibody

29393 100ul
EUR 439

SERPINI1 Polyclonal Antibody

29393-100ul 100ul
EUR 302.4

SERPINI1 Polyclonal Antibody

29393-50ul 50ul
EUR 224.4

Neuroserpin Antibody / SERPINI1

F54542-0.08ML 0.08 ml
EUR 140.25
Description: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Neuroserpin Antibody / SERPINI1

F54542-0.4ML 0.4 ml
EUR 322.15
Description: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Neuroserpin Antibody / SERPINI1

R32312 100 ug
EUR 356.15
Description: Neuroserpin is a protein that in humans is encoded by the SERPINI1 gene. This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.

SERPINI1 Antibody, HRP conjugated

1-CSB-PA859934LB01HU
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Description: A polyclonal antibody against SERPINI1. Recognizes SERPINI1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

Neuroserpin (SERPINI1) Antibody (HRP)

20-abx317628
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  • 100 ug
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SERPINI1 Antibody, FITC conjugated

1-CSB-PA859934LC01HU
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  • 100ug
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Description: A polyclonal antibody against SERPINI1. Recognizes SERPINI1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

OACD06129-1ML - SERPINI1 Antibody

OACD06129-1ML 1ml
EUR 669

Neuroserpin (SERPINI1) Antibody (HRP)

abx317628-100g 100 µg
EUR 362.5

Neuroserpin (SERPINI1) Antibody (HRP)

abx317628-20g 20 µg
EUR 162.5

Neuroserpin (SERPINI1) Antibody (HRP)

abx317628-50g 50 µg
EUR 250

Neuroserpin (SERPINI1) Antibody (FITC)

20-abx317629
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Neuroserpin (SERPINI1) Antibody (FITC)

abx317629-100g 100 µg
EUR 362.5

Neuroserpin (SERPINI1) Antibody (FITC)

abx317629-20g 20 µg
EUR 162.5

Neuroserpin (SERPINI1) Antibody (FITC)

abx317629-50g 50 µg
EUR 250

SERPINI1 Antibody, Biotin conjugated

1-CSB-PA859934LD01HU
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Description: A polyclonal antibody against SERPINI1. Recognizes SERPINI1 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

OAEB01731-100UG - SERPINI1 Antibody

OAEB01731-100UG 100ug
EUR 349

OACD06129-100UL - SERPINI1 Antibody

OACD06129-100UL 100ul
EUR 199

Neuroserpin (SERPINI1) Antibody (Biotin)

20-abx317630
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  • 100 ug
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Neuroserpin (SERPINI1) Antibody (Biotin)

abx317630-100g 100 µg
EUR 362.5

Neuroserpin (SERPINI1) Antibody (Biotin)

abx317630-20g 20 µg
EUR 162.5

Neuroserpin (SERPINI1) Antibody (Biotin)

abx317630-50g 50 µg
EUR 250

Polyclonal SERPINI1 Antibody (N-term)

APR13292G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SERPINI1 (N-term). This antibody is tested and proven to work in the following applications:

SERPINI1 Polyclonal Conjugated Antibody

C29393 100ul
EUR 476.4

Goat Polyclonal Antibody against SERPINI1

TA303009 100 µg Ask for price

ARP56616_P050-25UL - SERPINI1 Antibody - middle region

ARP56616_P050-25UL 25ul
EUR 99

Serpini1/ Rat Serpini1 ELISA Kit

ELI-13820r 96 Tests
EUR 1063.2

ARP56616_P050 - SERPINI1 antibody - middle region (ARP56616_P050)

ARP56616_P050 100ul
EUR 389

SERPINI1 (N-term) Rabbit Polyclonal Antibody

E10G30762 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

SERPINI1 mouse monoclonal antibody,clone OTI1A5

TA812171 100 µl Ask for price

SERPINI1 mouse monoclonal antibody,clone OTI1A5

TA812171S 30 µl Ask for price

SERPINI1

CSB-CL859934HU 10 μg plasmid + 200μl Glycerol Ask for price

SERPINI1

pro-213 5µg
EUR 60
Description: Recombinant Human Serpin Peptidase Inhibitor, Clade I Member 1

Monoclonal SERPINI1 Antibody (monoclonal) (M01), Clone: 1D10

APR13270G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human SERPINI1 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 1D10. This antibody is applicable in WB and IHC, E

Monoclonal SERPINI1 Antibody (monoclonal) (M03), Clone: 1E11

APR13291G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human SERPINI1 (monoclonal) (M03). The antibodies are raised in mouse and are from clone 1E11. This antibody is applicable in WB, E

SERPINI1 His

pro-1595 2µg
EUR 60
Description: Recombinant Human Serpin Peptidase Inhibitor, Clade I Member 1, His Tag

SERPINI1 siRNA

20-abx933024
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  • 15 nmol
  • 30 nmol

SERPINI1 siRNA

20-abx933025
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  • 15 nmol
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SERPINI1 siRNA

20-abx904882
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  • 15 nmol
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Neuroserpin (SERPINI1) rabbit polyclonal antibody, Aff - Purified

AP01329PU-N 100 µg Ask for price

Neuroserpin (SERPINI1) mouse monoclonal antibody, clone 1D10, Purified

AM31816PU-N 50 µg Ask for price

SERPINI1 Rabbit pAb

E2515703 100ul
EUR 225
Description: Available in various conjugation types.

SERPINI1 Rabbit pAb

A15703-100ul 100 ul
EUR 369.6

SERPINI1 Rabbit pAb

A15703-200ul 200 ul
EUR 550.8

SERPINI1 Rabbit pAb

A15703-20ul 20 ul
EUR 219.6

SERPINI1 Rabbit pAb

A15703-50ul 50 ul
EUR 267.6

SERPINI1 Rabbit pAb

A8833-100ul 100 ul
EUR 369.6

SERPINI1 Rabbit pAb

A8833-200ul 200 ul
EUR 550.8

SERPINI1 Rabbit pAb

A8833-20ul 20 ul Ask for price

SERPINI1 Rabbit pAb

A8833-50ul 50 ul Ask for price

Neuroserpin (SERPINI1) (N-term) rabbit polyclonal antibody, Aff - Purified

AP53865PU-N 400 µl Ask for price

SERPINI1 cloning plasmid

CSB-CL859934HU-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the SERPINI1 gene.

SERPINI1 Blocking Peptide

33R-1340 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ST6GALNAC6 antibody, catalog no. 70R-8664

RECOMBINANT HUMAN SERPINI1

GWB-3AFDFC 0.02 mg Ask for price

anti- SERPINI2 antibody

FNab07754 100µg
EUR 658.5
Description: Antibody raised against SERPINI2

Rat SERPINI1 shRNA Plasmid

20-abx987244
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  • 150 µg
  • 300 µg

Human SERPINI1 shRNA Plasmid

20-abx953523
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  • 150 µg
  • 300 µg

Mouse SERPINI1 shRNA Plasmid

20-abx972851
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  • 150 µg
  • 300 µg

Anti-MEPI / SERPINI2 antibody

STJ70679 100 µg
EUR 430.8

SERPINI1 (N-term) Rabbit pAb

E2611211 100ul
EUR 225
Description: Available in various conjugation types.

Serpini1 ORF Vector (Rat) (pORF)

ORF076094 1.0 ug DNA
EUR 607.2

Mouse Neuroserpin (SerpinI1) Protein

abx692199-100g 100 µg
EUR 837.5

Mouse Neuroserpin (SerpinI1) Protein

abx692199-1mg 1 mg Ask for price

Human SERPINI1 Protein, His Tag

E40KMPH2576 20ug
EUR 495

Mouse SERPINI1 Protein, His Tag

E40MOP1745 20ug
EUR 495

SERPINI1 ORF Vector (Human) (pORF)

ORF009401 1.0 ug DNA
EUR 114

Serpini1 ORF Vector (Mouse) (pORF)

ORF057067 1.0 ug DNA
EUR 607.2

Goat anti-MEPI / SERPINI2 Antibody

dAP-0676 50ug
EUR 264.6

Serpini1 (GFP-tagged) - Mouse serine (or cysteine) peptidase inhibitor, clade I, member 1 (Serpini1)

MG206454 10 µg Ask for price

Human SERPINI1 knockout cell line

ABC-KH13617 1 vial Ask for price
Description: Human SERPINI1 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Serpini1 (untagged) - Mouse serine (or cysteine) peptidase inhibitor, clade I, member 1 (Serpini1), (10ug)

MC200499 10 µg Ask for price

Human SERPINI1 knockdown cell line

ABC-KD13617 1 vial Ask for price
Description: Human SERPINI1 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

SERPINI1 ELISA Kit (Human) (OKCD01254)

OKCD01254 96 Wells
EUR 997.2
Description: Description of target: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.34 ng/mL

Rat Neuroserpin (SERPINI1) ELISA Kit

abx535108-96tests 96 tests
EUR 687.5

Mouse Neuroserpin, Serpini1 ELISA KIT

ELI-45671m 96 Tests
EUR 1038

Human Neuroserpin, SERPINI1 ELISA KIT

ELI-36796h 96 Tests
EUR 988.8

Human Neuroserpin (SERPINI1) ELISA Kit

EK7366 96Т
EUR 799

Human Neuroserpin (SERPINI1) ELISA Kit

AE19979HU-48Tests 48 Tests
EUR 325
Description: Human (Homo sapiens)

Human Neuroserpin (SERPINI1) ELISA Kit

AE19979HU-96Tests 96 Tests
EUR 610
Description: Human (Homo sapiens)

Human Neuroserpin (SERPINI1) ELISA Kit

KTE60688-48T 48T
EUR 339
Description: This Human Neuroserpin (SERPINI1) ELISA Kit employs a two-site sandwich ELISA to quantitate SERPINI1.

Human Neuroserpin (SERPINI1) ELISA Kit

KTE60688-96T 96T
EUR 589
Description: This Human Neuroserpin (SERPINI1) ELISA Kit employs a two-site sandwich ELISA to quantitate SERPINI1.

Human Neuroserpin (SERPINI1) ELISA Kit

KTE60688-96T5 96 T×5
EUR 2629
Description: This Human Neuroserpin (SERPINI1) ELISA Kit employs a two-site sandwich ELISA to quantitate SERPINI1.

Human Neuroserpin (SERPINI1) ELISA Kit

KTE60688-96T50 96 T×50
EUR 24569
Description: This Human Neuroserpin (SERPINI1) ELISA Kit employs a two-site sandwich ELISA to quantitate SERPINI1.

Mouse Neuroserpin (SERPINI1) ELISA Kit

abx535107-96tests 96 tests
EUR 687.5

Chicken Neuroserpin, SERPINI1 ELISA KIT

ELI-38297c 96 Tests
EUR 1113.6

Serpini1 (Myc-DDK-tagged) - Mouse serine (or cysteine) peptidase inhibitor, clade I, member 1 (Serpini1)

MR206454 10 µg Ask for price

Serpini1 (untagged ORF) - Rat serine (or cysteine) peptidase inhibitor, clade I, member 1 (Serpini1), (10 ug)

RN207046 10 µg Ask for price

SERPINI1 (untagged)-Human serpin peptidase inhibitor, clade I (neuroserpin), member 1 (SERPINI1), transcript variant 1

SC117018 10 µg Ask for price

SERPINI1 (untagged)-Human serpin peptidase inhibitor, clade I (neuroserpin), member 1 (SERPINI1), transcript variant 2

SC318861 10 µg Ask for price

SERPINI1 (GFP-tagged) - Human serpin peptidase inhibitor, clade I (neuroserpin), member 1 (SERPINI1), transcript variant 1

RG205290 10 µg Ask for price

SERPINI1 (GFP-tagged) - Human serpin peptidase inhibitor, clade I (neuroserpin), member 1 (SERPINI1), transcript variant 2

RG225640 10 µg Ask for price

Polyclonal Goat Anti-MEPI / SERPINI2 Antibody

APG00200G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-MEPI / SERPINI2 . This antibody is tested and proven to work in the following applications:

SERPINI1 3'UTR GFP Stable Cell Line

TU072979 1.0 ml
EUR 1672.8

Serpini1 3'UTR GFP Stable Cell Line

TU270193 1.0 ml Ask for price

Serpini1 3'UTR GFP Stable Cell Line

TU168648 1.0 ml Ask for price

ELISA kit for Human Neuroserpin (SERPINI1)

KTE60688-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Human Neuroserpin (SERPINI1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

OKCD01254-96W - SERPINI1 ELISA Kit (Human)

OKCD01254-96W 96Wells
EUR 675

OPCD05817-10UG - SERPINI1 Recombinant Protein

OPCD05817-10UG 10ug
EUR 129

OPCD05817-50UG - SERPINI1 Recombinant Protein

OPCD05817-50UG 50ug
EUR 309

Serpini1 sgRNA CRISPR Lentivector set (Rat)

K6996601 3 x 1.0 ug
EUR 406.8

OPCD05817-200UG - SERPINI1 Recombinant Protein

OPCD05817-200UG 200ug
EUR 609

Serpini1 (Myc-DDK-tagged ORF) - Rat serine (or cysteine) peptidase inhibitor, clade I, member 1 (Serpini1), (10 ug)

RR207046 10 µg Ask for price

SERPINI1 (Myc-DDK-tagged)-Human serpin peptidase inhibitor, clade I (neuroserpin), member 1 (SERPINI1), transcript variant 2

RC225640 10 µg Ask for price

SERPINI1 (Myc-DDK-tagged)-Human serpin peptidase inhibitor, clade I (neuroserpin), member 1 (SERPINI1), transcript variant 1

RC205290 10 µg Ask for price

SERPINI1 sgRNA CRISPR Lentivector set (Human)

K2126601 3 x 1.0 ug
EUR 406.8

Serpini1 sgRNA CRISPR Lentivector set (Mouse)

K3771501 3 x 1.0 ug
EUR 406.8

SERPINI1 Protein Vector (Rat) (pPM-C-HA)

PV304376 500 ng
EUR 723.6

SERPINI1 Protein Vector (Rat) (pPB-C-His)

PV304374 500 ng
EUR 723.6

SERPINI1 Protein Vector (Rat) (pPB-N-His)

PV304375 500 ng
EUR 723.6

SERPINI1 Protein Vector (Rat) (pPM-C-His)

PV304377 500 ng
EUR 723.6

Lenti ORF clone of Serpini1 (mGFP-tagged) - Mouse serine (or cysteine) peptidase inhibitor, clade I, member 1 (Serpini1)

MR206454L4 10 µg Ask for price
Conclusions: The addition of DPP-Four inhibitors to insulin remedy for grownup sufferers with sort 2 DM can considerably cut back HbA1c ranges with out growing the incidence of hypoglycemia. BMI and hypoglycemia definition might clarify the heterogeneity within the scientific trials. This trial is registered with PROSPERO