Utility of directed evolution and back-to-consensus algorithms to human alpha1-antitrypsin results in diminished anti-protease exercise and augmented anti-inflammatory actions
Mouse Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA equipment
-
Within the current examine, directed evolution and back-to-consensus algorithms have been utilized to human alpha1-antitrypsin. Six distinctive purposeful candidate websites have been recognized on the floor of the molecule; in manipulating these websites by level mutations, a recombinant mutant type of alpha1-antitrypsin was produced, depicting a requirement for websites outdoors the reactive middle loop as important for protease inhibition, and displaying enhanced anti-inflammatory actions.
Monoclonal SERPINA1 / Alpha 1 Antitrypsin Antibody (clone 9A1), Clone: 9A1
-
Taken collectively, outcomes of the current examine set up a possible use for directed evolution in advancing our understanding of site-specific protein features, providing a platform for growth of context- and disease-specific alpha1-antitrypsin-based therapeutics.
Key phrases: Alpha1-proteinase inhibitor; Protein construction; Recombinantprotein; SERPINA1.
 ELISA Kit) Sheep Plasma Protease C1 Inhibitor (SERPING1) ELISA Kit |
|
abx364213-96tests |
Abbexa |
96 tests |
EUR 926 |
- Shipped within 5-12 working days.
|
 Antibody) Plasma Protease C1 Inhibitor (Serping1) Antibody |
|
20-abx115476 |
Abbexa |
|
|
- Shipped within 5-10 working days.
|
 Antibody) Plasma Protease C1 Inhibitor (SERPING1) Antibody |
|
abx237753-100ug |
Abbexa |
100 ug |
EUR 509 |
- Shipped within 5-12 working days.
|
Plasma Protease C1 Inhibitor (SERPING1) Antibody |
|
20-abx339518 |
Abbexa |
|
|
- Shipped within 5-10 working days.
|
Plasma Protease C1 Inhibitor (SERPING1) Antibody |
|
20-abx339693 |
Abbexa |
|
|
- Shipped within 5-10 working days.
|
Plasma Protease C1 Inhibitor (SERPING1) Antibody |
|
20-abx324635 |
Abbexa |
|
|
- Shipped within 5-10 working days.
|
Plasma Protease C1 Inhibitor (SERPING1) Antibody |
|
20-abx302277 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
Plasma Protease C1 Inhibitor (SERPING1) Antibody |
|
20-abx001435 |
Abbexa |
-
EUR 411.00
-
EUR 592.00
-
EUR 182.00
-
EUR 314.00
|
-
100 ul
-
200 ul
-
20 ul
-
50 ul
|
- Shipped within 5-10 working days.
|
 Antibody (HRP)) Plasma Protease C1 Inhibitor (SERPING1) Antibody (HRP) |
|
20-abx316008 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
 Antibody (FITC)) Plasma Protease C1 Inhibitor (SERPING1) Antibody (FITC) |
|
20-abx316009 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
 Antibody (Biotin)) Plasma Protease C1 Inhibitor (SERPING1) Antibody (Biotin) |
|
20-abx316010 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
) Mouse Plasma protease C1 inhibitor (Serping1) |
|
1-CSB-EP021086MO |
Cusabio |
-
EUR 505.00
-
EUR 265.00
-
EUR 1827.00
-
EUR 766.00
-
EUR 1218.00
-
EUR 335.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 56.3 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
 Sheep Anti-Human C1 Esterase Inhibitor IgG, aff pure |
|
C1E11-A |
Alpha Diagnostics |
100 ug |
EUR 408 |
 ELISA kit) Human Plasma protease C1 inhibitor(SERPING1) ELISA kit |
|
CSB-EL021086HU-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
- Sample volume: 50-100ul
- Detection wavelength: 450nm
- Assay performance time: 1 to 4 hours.
|
Human Plasma protease C1 inhibitor(SERPING1) ELISA kit |
|
1-CSB-EL021086HU |
Cusabio |
-
EUR 703.00
-
EUR 4843.00
-
EUR 2570.00
|
-
1 plate of 96 wells
-
10 plates of 96 wells each
-
5 plates of 96 wells each
|
- Sample volume: 50-100ul
- Detection wavelength: 450nm
- Assay performance time: 1 to 4 hours.
|
 ELISA Kit) Human Plasma Protease C1 Inhibitor (SERPING1) ELISA Kit |
|
abx054430-96tests |
Abbexa |
96 tests |
EUR 786 |
- Shipped within 5-10 working days.
|
Human Plasma Protease C1 Inhibitor (SERPING1) ELISA Kit |
|
abx253748-96tests |
Abbexa |
96 tests |
EUR 754 |
- Shipped within 5-12 working days.
|
 Human SERPING1/ Plasma protease C1 inhibitor ELISA Kit |
|
E2265Hu |
Sunlong |
1 Kit |
EUR 605 |
Human Plasma Protease C1 Inhibitor (SERPING1) ELISA Kit |
|
abx512301-96tests |
Abbexa |
96 tests |
EUR 754 |
- Shipped within 5-12 working days.
|
) ELISA kit for Human Plasma protease C1 inhibitor (SERPING1) |
|
KTE60690-48T |
Abbkine |
48T |
EUR 354 |
ELISA kit for Human Plasma protease C1 inhibitor (SERPING1) |
|
KTE60690-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2252 |
ELISA kit for Human Plasma protease C1 inhibitor (SERPING1) |
|
KTE60690-96T |
Abbkine |
96T |
EUR 572 |
 ELISA kit) Mouse Plasma protease C1 inhibitor(SERPING1) ELISA kit |
|
CSB-EL021086MO-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
- Sample volume: 50-100ul
- Detection wavelength: 450nm
- Assay performance time: 1 to 4 hours.
|
Mouse Plasma protease C1 inhibitor(SERPING1) ELISA kit |
|
1-CSB-EL021086MO |
Cusabio |
-
EUR 804.00
-
EUR 5099.00
-
EUR 2704.00
|
-
1 plate of 96 wells
-
10 plates of 96 wells each
-
5 plates of 96 wells each
|
- Sample volume: 50-100ul
- Detection wavelength: 450nm
- Assay performance time: 1 to 4 hours.
|
 ELISA kit) Rat Plasma protease C1 inhibitor(SERPING1) ELISA kit |
|
CSB-EL021086RA-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
- Sample volume: 50-100ul
- Detection wavelength: 450nm
- Assay performance time: 1 to 4 hours.
|
Rat Plasma protease C1 inhibitor(SERPING1) ELISA kit |
|
1-CSB-EL021086RA |
Cusabio |
-
EUR 703.00
-
EUR 4843.00
-
EUR 2570.00
|
-
1 plate of 96 wells
-
10 plates of 96 wells each
-
5 plates of 96 wells each
|
- Sample volume: 50-100ul
- Detection wavelength: 450nm
- Assay performance time: 1 to 4 hours.
|
 Mouse Serping1/ Plasma protease C1 inhibitor ELISA Kit |
|
E1334Mo |
Sunlong |
1 Kit |
EUR 571 |
 ELISA Kit) Monkey Plasma Protease C1 Inhibitor (SERPING1) ELISA Kit |
|
abx359558-96tests |
Abbexa |
96 tests |
EUR 825 |
- Shipped within 5-12 working days.
|
 ELISA Kit) Pig Plasma Protease C1 Inhibitor (SERPING1) ELISA Kit |
|
abx361408-96tests |
Abbexa |
96 tests |
EUR 825 |
- Shipped within 5-12 working days.
|
 ELISA Kit) Rabbit Plasma Protease C1 Inhibitor (SERPING1) ELISA Kit |
|
abx362829-96tests |
Abbexa |
96 tests |
EUR 825 |
- Shipped within 5-12 working days.
|
 ELISA Kit) Chicken Plasma Protease C1 Inhibitor (SERPING1) ELISA Kit |
|
abx357151-96tests |
Abbexa |
96 tests |
EUR 825 |
- Shipped within 5-12 working days.
|
 ELISA Kit) Mouse Plasma protease C1 inhibitor (SERPING1) ELISA Kit |
|
abx512302-96tests |
Abbexa |
96 tests |
EUR 668 |
- Shipped within 5-12 working days.
|
 ELISA Kit) Rat Plasma protease C1 inhibitor (SERPING1) ELISA Kit |
|
abx512303-96tests |
Abbexa |
96 tests |
EUR 668 |
- Shipped within 5-12 working days.
|
) ELISA kit for Rat Plasma protease C1 inhibitor (SERPING1) |
|
KTE100269-48T |
Abbkine |
48T |
EUR 332 |
- C1-INH is a critically important protein that controls activation of multiple plasma mediator pathways. This protein, a member of the serine protease inhibitor (serpin) group, originally was described as an inhibitor of C1. It binds stoichiometricall
- Show more
|
ELISA kit for Rat Plasma protease C1 inhibitor (SERPING1) |
|
KTE100269-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2115 |
- C1-INH is a critically important protein that controls activation of multiple plasma mediator pathways. This protein, a member of the serine protease inhibitor (serpin) group, originally was described as an inhibitor of C1. It binds stoichiometricall
- Show more
|
ELISA kit for Rat Plasma protease C1 inhibitor (SERPING1) |
|
KTE100269-96T |
Abbkine |
96T |
EUR 539 |
- C1-INH is a critically important protein that controls activation of multiple plasma mediator pathways. This protein, a member of the serine protease inhibitor (serpin) group, originally was described as an inhibitor of C1. It binds stoichiometricall
- Show more
|
) ELISA kit for Mouse Plasma protease C1 inhibitor (SERPING1) |
|
KTE70448-48T |
Abbkine |
48T |
EUR 332 |
- C1-INH is a critically important protein that controls activation of multiple plasma mediator pathways. This protein, a member of the serine protease inhibitor (serpin) group, originally was described as an inhibitor of C1. It binds stoichiometricall
- Show more
|
ELISA kit for Mouse Plasma protease C1 inhibitor (SERPING1) |
|
KTE70448-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2115 |
- C1-INH is a critically important protein that controls activation of multiple plasma mediator pathways. This protein, a member of the serine protease inhibitor (serpin) group, originally was described as an inhibitor of C1. It binds stoichiometricall
- Show more
|
ELISA kit for Mouse Plasma protease C1 inhibitor (SERPING1) |
|
KTE70448-96T |
Abbkine |
96T |
EUR 539 |
- C1-INH is a critically important protein that controls activation of multiple plasma mediator pathways. This protein, a member of the serine protease inhibitor (serpin) group, originally was described as an inhibitor of C1. It binds stoichiometricall
- Show more
|
, Clone: 3F4-1D9) Monoclonal SERPING1 / C1 Inhibitor Antibody (clone 3F4-1D9), Clone: 3F4-1D9 |
|
AMM02062G |
Leading Biology |
0.05mg |
EUR 528 |
 Recombinant Mouse SerpinG1/ C1 inhibitor/ C1IN Protein, His, E.coli-100ug |
|
QP6676-ec-100ug |
EnQuireBio |
100ug |
EUR 571 |
 Recombinant Mouse SerpinG1/ C1 inhibitor/ C1IN Protein, His, E.coli-10ug |
|
QP6676-ec-10ug |
EnQuireBio |
10ug |
EUR 272 |
 Recombinant Mouse SerpinG1/ C1 inhibitor/ C1IN Protein, His, E.coli-1mg |
|
QP6676-ec-1mg |
EnQuireBio |
1mg |
EUR 2303 |
 Recombinant Mouse SerpinG1/ C1 inhibitor/ C1IN Protein, His, E.coli-200ug |
|
QP6676-ec-200ug |
EnQuireBio |
200ug |
EUR 898 |
 Recombinant Mouse SerpinG1/ C1 inhibitor/ C1IN Protein, His, E.coli-500ug |
|
QP6676-ec-500ug |
EnQuireBio |
500ug |
EUR 1514 |
 Recombinant Mouse SerpinG1/ C1 inhibitor/ C1IN Protein, His, E.coli-50ug |
|
QP6676-ec-50ug |
EnQuireBio |
50ug |
EUR 362 |
 C1 inhibitor antibody |
|
70R-12889 |
Fitzgerald |
100 ul |
EUR 457 |
C1 inhibitor antibody |
|
10R-2966 |
Fitzgerald |
100 ug |
EUR 265 |
 C1 Inhibitor antibody |
|
70R-7583 |
Fitzgerald |
1 mg |
EUR 356 |
 C1 Esterase Inhibitor antibody |
|
20R-1407 |
Fitzgerald |
5 mg |
EUR 337 |
C1 Esterase Inhibitor antibody |
|
70R-10618 |
Fitzgerald |
500 ug |
EUR 581 |
 C1 Esterase Inhibitor Antibody |
|
A1113-100 |
Biovision |
|
EUR 338 |
C1 Esterase Inhibitor Antibody |
|
A1113-30T |
Biovision |
|
EUR 146 |
，Member1(SERPING1) ELISA kit) Human Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA kit |
|
E01C0353-192T |
B-Gene |
192 tests |
EUR 1270 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
Human Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA kit |
|
E01C0353-48 |
B-Gene |
1 plate of 48 wells |
EUR 520 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
Human Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA kit |
|
E01C0353-96 |
B-Gene |
1 plate of 96 wells |
EUR 685 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
 Monoclonal Anti-Human C1 Esterase Inhibitor IgG, aff pure |
|
C1E12-M |
Alpha Diagnostics |
100 ul |
EUR 482 |
 Goat anti-Human C1 Esterase Inhibitor polyclonal antibody |
|
CABT-L506 |
Creative Diagnostics |
500ug |
EUR 819 |
Goat anti-Human C1 Esterase Inhibitor polyclonal antibody |
|
CABT-L507 |
Creative Diagnostics |
200ug |
EUR 663 |
 C1 Inhibitor, Human Recombinant |
|
7120-200 |
Biovision |
|
EUR 398 |
C1 Inhibitor, Human Recombinant |
|
7120-50 |
Biovision |
|
EUR 169 |
 Polyclonal Antibody (Sheep)) Immunoglobulin G (IgG) Polyclonal Antibody (Sheep) |
|
4-PAA544Ov01 |
Cloud-Clone |
-
EUR 251.00
-
EUR 2576.00
-
EUR 640.00
-
EUR 316.00
-
EUR 215.00
|
-
100ul
-
10ml
-
1ml
-
200ul
-
20ul
|
- Sequence of the immunogen: Native Protein
- Buffer composition: May vary. Inquire for the exact composition.
|
 Sheep IgG |
|
E61I019 |
EnoGene |
1mg |
EUR 343 |
，Member1(SERPING1) ELISA kit) Goat Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA kit |
|
E06C0353-192T |
B-Gene |
192 tests |
EUR 1270 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
Goat Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA kit |
|
E06C0353-48 |
B-Gene |
1 plate of 48 wells |
EUR 520 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
Goat Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA kit |
|
E06C0353-96 |
B-Gene |
1 plate of 96 wells |
EUR 685 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
，Member1(SERPING1) ELISA kit) Mouse Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA kit |
|
E03C0353-192T |
B-Gene |
192 tests |
EUR 1270 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
Mouse Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA kit |
|
E03C0353-48 |
B-Gene |
1 plate of 48 wells |
EUR 520 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
Mouse Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA kit |
|
E03C0353-96 |
B-Gene |
1 plate of 96 wells |
EUR 685 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
，Member1(SERPING1) ELISA kit) Rabbit Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA kit |
|
E04C0353-192T |
B-Gene |
192 tests |
EUR 1270 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
Rabbit Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA kit |
|
E04C0353-48 |
B-Gene |
1 plate of 48 wells |
EUR 520 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
Rabbit Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA kit |
|
E04C0353-96 |
B-Gene |
1 plate of 96 wells |
EUR 685 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
，Member1(SERPING1) ELISA kit) Rat Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA kit |
|
E02C0353-192T |
B-Gene |
192 tests |
EUR 1270 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
Rat Serpin Peptidase Inhibitor，Clade G (C1 Inhibitor)，Member1(SERPING1) ELISA kit |
|
E02C0353-48 |
B-Gene |
1 plate of 48 wells |
EUR 520 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
Alpha-1 antitrypsin governs alcohol-related liver illness in mice and people
Goal: Alcohol-related liver illness (ALD) is a world healthcare drawback with restricted therapy options. Alpha-1 antitrypsin (AAT, encoded by SERPINA1) exhibits potent anti-inflammatory actions in lots of preclinical and scientific trials. In our examine, we aimed to discover the function of AAT in ALD.
Design: An unselected cohort of 512 sufferers with cirrhosis was clinically characterised. Survival, scientific and biochemical parameters together with AAT serum focus have been in contrast between sufferers with ALD and different aetiologies of liver illness. The function of AAT was evaluated in experimental ALD fashions.
Monoclonal SERPINA1 / Alpha 1 Antitrypsin Antibody (clone 48D2), Clone: 48D2
Outcomes: Cirrhotic ALD sufferers with AAT serum concentrations lower than 120 mg/dL had a considerably greater danger for demise/liver transplantation as in contrast with sufferers with AAT serum concentrations greater than 120 mg/dL. Multivariate Cox regression evaluation confirmed that low AAT serum focus was a NaMELD-independent predictor of survival/transplantation. Ethanol-fed wild-type (wt) mice displayed a major decline in hepatic AAT in contrast with pair-fed mice. Due to this fact, hAAT-Tg mice have been ethanol-fed, and these mice displayed safety from liver damage related to decreased steatosis, hepatic neutrophil infiltration and abated expression of proinflammatory cytokines. To check the therapeutic functionality of AAT, ethanol-fed wt mice have been handled with human AAT. Administration of AAT ameliorated hepatic damage, neutrophil infiltration and steatosis.
Rabbit Alpha-1-Antitrypsin (SERPINA1) ELISA Equipment
 Anti-SERPINA1/Alpha 1 Antitrypsin Rabbit Monoclonal Antibody |
|
M00720-1 |
BosterBio |
100ug/vial |
EUR 397 |
 Anti-alpha 1 Antitrypsin/SERPINA1 Antibody |
|
PB10097 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-alpha 1 Antitrypsin/SERPINA1 Antibody |
|
PB9354 |
BosterBio |
100ug/vial |
EUR 334 |
 Antibody) alpha 1 Antitrypsin (SERPINA1) Antibody |
|
abx022446-1mg |
Abbexa |
1 mg |
EUR 648 |
- Shipped within 5-10 working days.
|
alpha 1 Antitrypsin (SERPINA1) Antibody |
|
abx022447-1mg |
Abbexa |
1 mg |
EUR 871 |
- Shipped within 5-10 working days.
|
alpha 1 Antitrypsin (SERPINA1) Antibody |
|
abx023901-02mg |
Abbexa |
0.2 mg |
EUR 578 |
- Shipped within 5-10 working days.
|
 Antibody) alpha 1-Antitrypsin (SERPINA1) Antibody |
|
abx019008-100ug |
Abbexa |
100 ug |
EUR 342 |
- Shipped within 5-10 working days.
|
 Antibody) Alpha-1-Antitrypsin (SERPINA1) Antibody |
|
abx218526-100ug |
Abbexa |
100 ug |
EUR 439 |
- Shipped within 5-10 working days.
|
Alpha-1-Antitrypsin (SERPINA1) Antibody |
|
abx224268-100ug |
Abbexa |
100 ug |
EUR 411 |
- Shipped within 5-10 working days.
|
Alpha-1-Antitrypsin (SERPINA1) Antibody |
|
20-abx115459 |
Abbexa |
|
|
- Shipped within 5-10 working days.
|
Alpha-1-Antitrypsin (SERPINA1) Antibody |
|
abx034372-400ul |
Abbexa |
400 ul |
EUR 523 |
- Shipped within 5-10 working days.
|
Alpha-1-Antitrypsin (SERPINA1) Antibody |
|
abx034372-80l |
Abbexa |
80 µl |
EUR 286 |
- Shipped within 5-10 working days.
|
Alpha-1-Antitrypsin (SERPINA1) Antibody |
|
abx411121-1mg |
Abbexa |
1 mg |
EUR 801 |
|
|
 Antibody) alpha-1-Antitrypsin (SERPINA1) Antibody |
|
abx432314-200ul |
Abbexa |
200 ul |
EUR 384 |
- Shipped within 1-3 working days.
|
alpha-1-Antitrypsin (SERPINA1) Antibody |
|
abx432315-200ul |
Abbexa |
200 ul |
EUR 384 |
- Shipped within 1-3 working days.
|
Alpha-1-Antitrypsin (SERPINA1) Antibody |
|
20-abx306530 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
Alpha-1-Antitrypsin (SERPINA1) Antibody |
|
abx224395-100ug |
Abbexa |
100 ug |
EUR 411 |
- Shipped within 5-10 working days.
|
Alpha-1-Antitrypsin (SERPINA1) Antibody |
|
abx230337-100ug |
Abbexa |
100 ug |
EUR 509 |
- Shipped within 5-12 working days.
|
Alpha-1-Antitrypsin (SERPINA1) Antibody |
|
abx230338-100ug |
Abbexa |
100 ug |
EUR 551 |
- Shipped within 5-12 working days.
|
Alpha-1-Antitrypsin (SERPINA1) Antibody |
|
20-abx000959 |
Abbexa |
-
EUR 411.00
-
EUR 592.00
-
EUR 182.00
-
EUR 314.00
|
-
100 ul
-
200 ul
-
20 ul
-
50 ul
|
- Shipped within 5-10 working days.
|
 Monoclonal SERPINA1 / Alpha 1 Antitrypsin Antibody |
|
AMR09872G |
Leading Biology |
0.05mg |
EUR 484 |
 Polyclonal SERPINA1 / Alpha 1 Antitrypsin Antibody |
|
AMR09873G |
Leading Biology |
0.05ml |
EUR 484 |
Polyclonal SERPINA1 / Alpha 1 Antitrypsin Antibody |
|
AMR09874G |
Leading Biology |
0.05mg |
EUR 484 |
 Antibody (HRP)) Alpha-1-Antitrypsin (SERPINA1) Antibody (HRP) |
|
abx411774-1ml |
Abbexa |
1 ml |
EUR 509 |
|
|
Alpha-1-Antitrypsin (SERPINA1) Antibody (HRP) |
|
20-abx306531 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
 Antibody (FITC)) Alpha-1-Antitrypsin (SERPINA1) Antibody (FITC) |
|
20-abx306532 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
 Antibody (Biotin)) Alpha-1-Antitrypsin (SERPINA1) Antibody (Biotin) |
|
20-abx306533 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
 Protein) Human Alpha-1-Antitrypsin (SERPINA1) Protein |
|
abx670006-2mg |
Abbexa |
2 mg |
EUR 495 |
|
|
 ELISA Kit) Human Alpha-1-Antitrypsin (SERPINA1) ELISA Kit |
|
abx051181-96tests |
Abbexa |
96 tests |
EUR 707 |
- Shipped within 5-12 working days.
|
Human Alpha-1-Antitrypsin (SERPINA1) ELISA Kit |
|
20-abx150622 |
Abbexa |
-
EUR 7112.00
-
EUR 3792.00
-
EUR 879.00
|
-
10 × 96 tests
-
5 × 96 tests
-
96 tests
|
- Shipped within 5-7 working days.
|
Human Alpha-1-Antitrypsin (SERPINA1) ELISA Kit |
|
abx253369-96tests |
Abbexa |
96 tests |
EUR 707 |
- Shipped within 5-12 working days.
|
 Human SERPINA1/ Alpha-1-antitrypsin ELISA Kit |
|
E2247Hu |
Sunlong |
1 Kit |
EUR 537 |
 Human Alpha- 1- antitrypsin, SERPINA1 ELISA KIT |
|
ELI-05520h |
Lifescience Market |
96 Tests |
EUR 824 |
 ELISA Kit) Human Alpha 1 Antitrypsin (SERPINA1) ELISA Kit |
|
abx575223-96tests |
Abbexa |
96 tests |
EUR 668 |
- Shipped within 5-12 working days.
|
 ELISA kit) Bovine Alpha-1-antitrypsin(SERPINA1) ELISA kit |
|
CSB-EL021053BO-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
- Sample volume: 50-100ul
- Detection wavelength: 450nm
- Assay performance time: 1 to 4 hours.
|
Bovine Alpha-1-antitrypsin(SERPINA1) ELISA kit |
|
1-CSB-EL021053BO |
Cusabio |
-
EUR 703.00
-
EUR 4843.00
-
EUR 2570.00
|
-
1 plate of 96 wells
-
10 plates of 96 wells each
-
5 plates of 96 wells each
|
- Sample volume: 50-100ul
- Detection wavelength: 450nm
- Assay performance time: 1 to 4 hours.
|
 ELISA kit) Mouse Alpha-1-antitrypsin(SERPINA1) ELISA kit |
|
CSB-EL021053MO-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
- Sample volume: 50-100ul
- Detection wavelength: 450nm
- Assay performance time: 1 to 4 hours.
|
Mouse Alpha-1-antitrypsin(SERPINA1) ELISA kit |
|
1-CSB-EL021053MO |
Cusabio |
-
EUR 703.00
-
EUR 4843.00
-
EUR 2570.00
|
-
1 plate of 96 wells
-
10 plates of 96 wells each
-
5 plates of 96 wells each
|
- Sample volume: 50-100ul
- Detection wavelength: 450nm
- Assay performance time: 1 to 4 hours.
|
 ELISA kit) Rat Alpha-1-antitrypsin(SERPINA1) ELISA kit |
|
CSB-EL021053RA-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
- Sample volume: 50-100ul
- Detection wavelength: 450nm
- Assay performance time: 1 to 4 hours.
|
Rat Alpha-1-antitrypsin(SERPINA1) ELISA kit |
|
1-CSB-EL021053RA |
Cusabio |
-
EUR 804.00
-
EUR 5099.00
-
EUR 2704.00
|
-
1 plate of 96 wells
-
10 plates of 96 wells each
-
5 plates of 96 wells each
|
- Sample volume: 50-100ul
- Detection wavelength: 450nm
- Assay performance time: 1 to 4 hours.
|
 ELISA Kit) Mouse Alpha-1-Antitrypsin (SERPINA1) ELISA Kit |
|
20-abx153620 |
Abbexa |
-
EUR 7237.00
-
EUR 3855.00
-
EUR 895.00
|
-
10 × 96 tests
-
5 × 96 tests
-
96 tests
|
- Shipped within 5-7 working days.
|
 ELISA Kit) Rat Alpha-1-Antitrypsin (SERPINA1) ELISA Kit |
|
20-abx155181 |
Abbexa |
-
EUR 7378.00
-
EUR 3933.00
-
EUR 911.00
|
-
10 × 96 tests
-
5 × 96 tests
-
96 tests
|
- Shipped within 5-7 working days.
|
 ELISA Kit) Mouse Alpha 1 Antitrypsin (SERPINA1) ELISA Kit |
|
abx259306-96tests |
Abbexa |
96 tests |
EUR 746 |
- Shipped within 5-12 working days.
|
 Porcine Alpha- 1- antitrypsin, SERPINA1 ELISA KIT |
|
ELI-05523p |
Lifescience Market |
96 Tests |
EUR 928 |
 ELISA Kit) Monkey Alpha-1-Antitrypsin (SERPINA1) ELISA Kit |
|
abx359660-96tests |
Abbexa |
96 tests |
EUR 825 |
- Shipped within 5-12 working days.
|
 ELISA Kit) Pig Alpha-1-Antitrypsin (SERPINA1) ELISA Kit |
|
abx361894-96tests |
Abbexa |
96 tests |
EUR 825 |
- Shipped within 5-12 working days.
|
 ELISA Kit) Chicken Alpha-1-Antitrypsin (SERPINA1) ELISA Kit |
|
abx356694-96tests |
Abbexa |
96 tests |
EUR 825 |
- Shipped within 5-12 working days.
|
 ELISA Kit) Dog Alpha-1-Antitrypsin (SERPINA1) ELISA Kit |
|
abx355458-96tests |
Abbexa |
96 tests |
EUR 887 |
- Shipped within 5-12 working days.
|
 ELISA Kit) Rabbit Alpha-1-Antitrypsin (SERPINA1) ELISA Kit |
|
abx363451-96tests |
Abbexa |
96 tests |
EUR 825 |
- Shipped within 5-12 working days.
|
 ELISA Kit) Sheep Alpha-1-Antitrypsin (SERPINA1) ELISA Kit |
|
abx364501-96tests |
Abbexa |
96 tests |
EUR 926 |
- Shipped within 5-12 working days.
|
Mouse Alpha-1-Antitrypsin (SERPINA1) ELISA Kit |
|
abx575399-96tests |
Abbexa |
96 tests |
EUR 786 |
- Shipped within 5-12 working days.
|
Rat Alpha-1-Antitrypsin (SERPINA1) ELISA Kit |
|
abx576108-96tests |
Abbexa |
96 tests |
EUR 786 |
- Shipped within 5-12 working days.
|
 ELISA Kit) Cow Alpha 1 Antitrypsin (SERPINA1) ELISA Kit |
|
abx518179-96tests |
Abbexa |
96 tests |
EUR 911 |
- Shipped within 5-12 working days.
|
 ELISA Kit) Rat Alpha 1 Antitrypsin (SERPINA1) ELISA Kit |
|
abx518182-96tests |
Abbexa |
96 tests |
EUR 668 |
- Shipped within 5-12 working days.
|
) ELISA kit for Human Alpha-1-antitrypsin (SERPINA1) |
|
KTE60707-48T |
Abbkine |
48T |
EUR 332 |
- alpha1-antitrypsin, an acute phase protein, is the prototypic member of the serpin super family and a major inhibitor of serine proteases. As an acute phase protein, alpha 1-antitrypsin is thought to play an important role in limiting host tissue inj
- Show more
|
ELISA kit for Human Alpha-1-antitrypsin (SERPINA1) |
|
KTE60707-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2115 |
- alpha1-antitrypsin, an acute phase protein, is the prototypic member of the serpin super family and a major inhibitor of serine proteases. As an acute phase protein, alpha 1-antitrypsin is thought to play an important role in limiting host tissue inj
- Show more
|
ELISA kit for Human Alpha-1-antitrypsin (SERPINA1) |
|
KTE60707-96T |
Abbkine |
96T |
EUR 539 |
- alpha1-antitrypsin, an acute phase protein, is the prototypic member of the serpin super family and a major inhibitor of serine proteases. As an acute phase protein, alpha 1-antitrypsin is thought to play an important role in limiting host tissue inj
- Show more
|
 alpha-1 antitrypsin fragment |
|
A1051-1 |
ApexBio |
1 mg |
EUR 108 |
 (Hepatocellular & Histiocytic Marker) Monoclonal Antibody) Anti-Alpha-1-Antitrypsin (SERPINA1) (Hepatocellular & Histiocytic Marker) Monoclonal Antibody |
|
M00720 |
BosterBio |
100ug/vial |
EUR 397 |
) ELISA kit for Rat Alpha-1-antitrypsin (SERPINA1) |
|
KTE100274-48T |
Abbkine |
48T |
EUR 332 |
- alpha1-antitrypsin, an acute phase protein, is the prototypic member of the serpin super family and a major inhibitor of serine proteases. As an acute phase protein, alpha 1-antitrypsin is thought to play an important role in limiting host tissue inj
- Show more
|
ELISA kit for Rat Alpha-1-antitrypsin (SERPINA1) |
|
KTE100274-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2115 |
- alpha1-antitrypsin, an acute phase protein, is the prototypic member of the serpin super family and a major inhibitor of serine proteases. As an acute phase protein, alpha 1-antitrypsin is thought to play an important role in limiting host tissue inj
- Show more
|
ELISA kit for Rat Alpha-1-antitrypsin (SERPINA1) |
|
KTE100274-96T |
Abbkine |
96T |
EUR 539 |
- alpha1-antitrypsin, an acute phase protein, is the prototypic member of the serpin super family and a major inhibitor of serine proteases. As an acute phase protein, alpha 1-antitrypsin is thought to play an important role in limiting host tissue inj
- Show more
|
 anti- Alpha-1-Antitrypsin antibody |
|
FNab00337 |
FN Test |
100µg |
EUR 548.75 |
- Recommended dilution: WB: 1:500 - 1:2000
- IHC: 1:50 - 1:200
- Immunogen: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
- Uniprot ID: P01009
- Gene ID: 5265
- Research Area: Cancer, Immunology, Cardiovascular, Metabolism
|
anti- Alpha-1-Antitrypsin antibody |
|
FNab00338 |
FN Test |
100µg |
EUR 585 |
- Recommended dilution: WB: 1:500-1:5000
- IP: 1:500-1:2000
- IF: 1:20-1:200
- IHC: 1:500-1:1000
- Immunogen: serpin peptidase inhibitor, clade A(alpha-1 antiproteinase, antitrypsin), member 1
- Uniprot ID: P01009
- Gene ID: 5265
- Research Area: Cancer, Immunolo
- Show more
|
 anti-alpha 1 Antitrypsin |
|
YF-PA13777 |
Abfrontier |
100 ug |
EUR 403 |
, Clone: 11G2) Monoclonal SERPINA1 / Alpha 1 Antitrypsin Antibody (clone 11G2), Clone: 11G2 |
|
AMR09875G |
Leading Biology |
0.05ml |
EUR 484 |
, Clone: 15H10) Monoclonal SERPINA1 / Alpha 1 Antitrypsin Antibody (clone 15H10), Clone: 15H10 |
|
AMR09876G |
Leading Biology |
0.05ml |
EUR 484 |
, Clone: 48D2) Monoclonal SERPINA1 / Alpha 1 Antitrypsin Antibody (clone 48D2), Clone: 48D2 |
|
AMR09877G |
Leading Biology |
0.05ml |
EUR 484 |
, Clone: 5B12) Monoclonal SERPINA1 / Alpha 1 Antitrypsin Antibody (clone 5B12), Clone: 5B12 |
|
AMR09878G |
Leading Biology |
0.05ml |
EUR 484 |
, Clone: 9A1) Monoclonal SERPINA1 / Alpha 1 Antitrypsin Antibody (clone 9A1), Clone: 9A1 |
|
AMR09898G |
Leading Biology |
0.05ml |
EUR 484 |
 IgG, unlabeled) Goat Anti-Human Alpha 1-Antitrypsin (A1AT) IgG, unlabeled |
|
A1AT11-A |
Alpha Diagnostics |
100 ul |
EUR 408 |
 IgG, Biotin conjugate) Goat Anti-Human Alpha 1-Antitrypsin (A1AT) IgG, Biotin conjugate |
|
A1AT11-BT |
Alpha Diagnostics |
100 ul |
EUR 408 |
 IgG, HRP conjugate) Goat Anti-Human Alpha 1-Antitrypsin (A1AT) IgG, HRP conjugate |
|
A1AT11-HRP |
Alpha Diagnostics |
100 ul |
EUR 408 |
 (Hepatocellular & Histiocytic Marker) (AAT/1378) Antibody) Alpha-1-Antitrypsin (SERPINA1) (Hepatocellular & Histiocytic Marker) (AAT/1378) Antibody |
|
BNUM1378-50 |
Biotium |
50uL |
EUR 395 |
 (Hepatocellular & Histiocytic Marker) (AAT/1379) Antibody) Alpha-1-Antitrypsin (SERPINA1) (Hepatocellular & Histiocytic Marker) (AAT/1379) Antibody |
|
BNUM1379-50 |
Biotium |
50uL |
EUR 395 |
Conclusion: Cirrhotic ALD patients with AAT concentrations much less than 120 mg/dL displayed an elevated danger for demise/liver transplantation. Each hAAT-Tg mice and AAT-treated wt animals confirmed safety from ethanol-induced liver damage. AAT may replicate a therapy choice for human ALD, particularly for alcoholic hepatitis.
Key phrases: ALCOHOLIC LIVER DISEASE; LIVER CIRRHOSIS.
- The α-1-antitrypsin (or alpha-1-antitrypsin, A1AT) Z variant is the first reason for extreme A1AT deficiency and kinds polymeric chains that mixture within the endoplasmic reticulum of hepatocytes. Round 2%-5% of Europeans are heterozygous for the Z and WT M allele, and there’s proof of elevated danger of liver illness in comparison with MM A1AT people.
- Now we have proven that Z and M A1AT can copolymerize in cell fashions, however there was no direct statement of heteropolymer formation in vivo.
)
 Polyclonal Antibody)
